ID G1SK31_RABIT Unreviewed; 1873 AA.
AC G1SK31;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 76.
DE SubName: Full=Coiled-coil domain containing 88A {ECO:0000313|Ensembl:ENSOCUP00000003141.4};
GN Name=CCDC88A {ECO:0000313|Ensembl:ENSOCUP00000003141.4};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000003141.4, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000003141.4, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000003141.4,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000003141.4}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000003141.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAGW02006457; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02006458; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02006459; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02006460; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02006461; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02006462; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02006463; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSOCUT00000003621.4; ENSOCUP00000003141.4; ENSOCUG00000003620.4.
DR eggNOG; KOG4643; Eukaryota.
DR GeneTree; ENSGT00940000155559; -.
DR HOGENOM; CLU_001421_1_0_1; -.
DR TreeFam; TF320231; -.
DR Proteomes; UP000001811; Chromosome 2.
DR Bgee; ENSOCUG00000003620; Expressed in testis and 16 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0030705; P:cytoskeleton-dependent intracellular transport; IEA:InterPro.
DR Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR043936; HOOK_N.
DR PANTHER; PTHR18947:SF30; GIRDIN; 1.
DR PANTHER; PTHR18947; HOOK PROTEINS; 1.
DR Pfam; PF19047; HOOK_N; 1.
DR SUPFAM; SSF116907; Hook domain; 1.
DR PROSITE; PS50021; CH; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811}.
FT DOMAIN 7..133
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT REGION 817..843
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1010..1036
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1408..1460
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1560..1602
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1633..1656
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1810..1873
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 247..426
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1126..1233
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1269..1384
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1417..1460
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1834..1858
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1859..1873
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1873 AA; 216117 MW; 21F53D92BA3270C3 CRC64;
MTLEWSPKDK RTQGTSCRGT SQVKTFGPLA AGSGTNLDEY VALVDGVFLN QVMLQINPKS
ESQRVNKKVN NDASLRIHNL SILVRQIKFY YQETLQQLIM MSLPNVLIIG KNPFSEQGTE
EVKKLLLLLL GCAVQCQKKE EFIERIQGLD FDTKAAVAAH IQEVTHNQEN VFDLQWMEVT
DMSQEDIEPL LKNMALHLKR LIDERDEHSE TIVELSEERD GLHFLPHASS TAQSPCGSPG
MKRTESRQHL SVELADAKAK IRRLRQELEE KTEQLLDCKQ ELEQMEIELK RLQQENMNLI
SDARSARMYR DELDALREKA IRVDKLESEV SRYKERLHDI EFYKARVEEL KEDNQVLLET
KTMLEDQLEG TRARSDKLHE LEKENLQLKA KLHDMEMERD MDRKKIEELM EENMTLEMAQ
KQSMDESLHL GWELEQISRT SELSEAPQKS LGHEVNELTS SRLLKLEMEN QSLTKTVEEL
RSSMESVEGN TSKILKIEKE NQRLSRKVEM LENEIIQEKQ SLQNCQNLSK DLMKEKAQLE
KTIETLRENS ERQIKMLEQE NEHLNQTVSS LRQRSQISAE ARVKDIEKEN KILHESIKET
SSKLSKIEFE KRQIRKELEH YKEKGERAEE LENELHHLEK ENELLQKKIT NLKITCEKTE
ALEHENSELE KENRKLKKTL DSFKNLTFQL ESLEKENSQL DEENLELRRN VESLKCASMK
MAQLQLENKE LESEKEQLKK GLELMKASFK KTERLEVSYQ GLDTENQRLQ KALENSNKKI
QQLESELQDL EVENQTLQKN LEELKISSKR LEQLEKENKS LEQETSQLEK DKKQLEKENK
RLRQQAEIKD TTLEENNVKI GNLEKENKSL FKEIGVYKES CTRLKELEKE NKELVKRATI
DIKTLVTLRE DLVSEKLKTQ QMNNDLEKLT HELEKIGLNK ERLLHDEQST DDSRYKLLES
KLESTLKKSL EIKEEKIAAL EARLEESTNY NQQLRQELKT VKKNYEALKQ RQDEEQMVQS
SPPLSGEDNK WERESQETTR ELLKVKDRLI EVERNNATLQ AEKQALKTQL KQLETQNNNL
QAQILALQRQ TVSLQEQNTT LQTQNAKLQV ENSTLNSQST SLMNQNAQLL IQQSSLENEN
ESVIKEREDL KSLYDSLIKD HEKLELLHER QALEYESLIS KHGTLKSAHK NLEVEHKDLE
DRYNQLLKQK GQLEDLEKVL KVEQEKMLLE NKNHETVAAE YRKLCGENDR LNHTYSQLLK
ETEVLQTDHK NLKSLLNNSK LEQTRLEAEF SKLKEQYQQL DITSTKLNNQ CELLSQLKGN
LEEENRHLLD QIQTLMLQNR TLLEQNMESK DLFHVEQRQY IDKLNELRRQ KEKLEEKIMD
QYKFYDPSPP RRRGNWITLK MRKLIKSKKD INRDRQKSLT LTPTRSDSSE GFLQLPHQDS
QDSSSVGSNS LEDGQTLGTK KSSMVALKRL PFLRNRPKDK DKMKACYRRS MSMNDLVQSM
VLAGQWTGSS ENLEVPDDIS TGKRRKELGA MAFSTTAINF STVNSSAGFR SKQLVNNKDT
TSFEDISPQG ISDDSSTGSR VHASRPASLD SGRTSTSNSN NNASLHEVKA GAVNNQSRPQ
SHSSGEFSLL HDHETWSSSG SSPIQYLKRQ TRSSPVLQHK MPETLESRAY HKIKTGSPGS
EVVTLQQFLE ESNKLTSIQI KSSSQENLLD EVMKSLSVSS DFLGKDKPVS CGLSRSVSGK
APGDFYDRRT TKPEFVRPGP RKTEDACFIS SAGKPTQGTQ GKMKIVKETS LSRQSKDSNP
YATLPRASSV ISTAEGTTRR TSIHDFLTKD SRLPVSVDSP SSTADSSSTA ASNMDKVQES
RNSKSRSREQ QSS
//
