ID G1SN33_RABIT Unreviewed; 1131 AA.
AC G1SN33;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 59.
DE RecName: Full=Structural maintenance of chromosomes protein 1A {ECO:0000256|ARBA:ARBA00017530};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000004366.3, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000004366.3, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000004366.3,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000004366.3}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000004366.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|ARBA:ARBA00004286}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the SMC family. SMC1 subfamily.
CC {ECO:0000256|ARBA:ARBA00005597}.
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DR EMBL; AAGW02064452; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02064453; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02064454; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1SN33; -.
DR PaxDb; 9986-ENSOCUP00000004366; -.
DR Ensembl; ENSOCUT00000005040.3; ENSOCUP00000004366.3; ENSOCUG00000005034.3.
DR eggNOG; KOG0018; Eukaryota.
DR GeneTree; ENSGT00940000155614; -.
DR HOGENOM; CLU_057899_1_1_1; -.
DR Proteomes; UP000001811; Chromosome X.
DR Bgee; ENSOCUG00000005034; Expressed in autopod skin and 16 other cell types or tissues.
DR GO; GO:0008278; C:cohesin complex; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0051321; P:meiotic cell cycle; IEA:UniProt.
DR GO; GO:0007062; P:sister chromatid cohesion; IEA:InterPro.
DR CDD; cd03275; ABC_SMC1_euk; 1.
DR Gene3D; 1.20.1060.20; -; 1.
DR Gene3D; 3.30.70.1620; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR003395; RecF/RecN/SMC_N.
DR InterPro; IPR024704; SMC.
DR InterPro; IPR028468; Smc1_ABC.
DR InterPro; IPR010935; SMC_hinge.
DR InterPro; IPR036277; SMC_hinge_sf.
DR PANTHER; PTHR18937:SF170; STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 1A; 1.
DR PANTHER; PTHR18937; STRUCTURAL MAINTENANCE OF CHROMOSOMES SMC FAMILY MEMBER; 1.
DR Pfam; PF06470; SMC_hinge; 1.
DR Pfam; PF02463; SMC_N; 1.
DR PIRSF; PIRSF005719; SMC; 2.
DR SMART; SM00968; SMC_hinge; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR SUPFAM; SSF75553; Smc hinge domain; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Meiosis {ECO:0000256|ARBA:ARBA00023254};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811}.
FT DOMAIN 486..602
FT /note="SMC hinge"
FT /evidence="ECO:0000259|SMART:SM00968"
FT REGION 257..280
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 845..866
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 637..684
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 726..823
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 890..963
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 847..866
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1131 AA; 130968 MW; 010381FBDC9A1BB9 CRC64;
MPGVLTPIRG KSNLMDAISF VLGEKTSNLR VKTLRDLIHG APVGKPAANR AFVSMVYSED
GAEDRTFARV IVGGSSEYKI NNKVVQLHEY SEELEKLGIL IKARNFLVFQ GAVESIAMKN
PKERTALFEE ISRSGELAQE YDKRKKEMVK AEEDTQFNYH RKKNIAAERK EAKQEKEEAD
RYQRLKDEVV RAQVQLQLFK LYHNEVEIEK LNKELASKNK EIEKDKKRMD KVEDELKEKK
KELGKMMREQ QQIEKEIKEK DSELNQKRPQ YIKAKENTSH KIKKLEAAKK SLQNAQKHYK
KRKGDMDELE KEMLSVEKAR QEFEERMEEE SQSQGRDLTL EENQVKKYHR LKEEASKRAA
TLAQELEKFN RDQKADQDRL DLEERKKVET EAKIKQKLRE IEENQKRIEK LEEYITTSKQ
SLEEQKKLEG ELTEEVEMAK RRIDEINKEL NQVMEQLGDA RIDRQESSRQ QRKAEIMESI
KRLYPGSVYG RLIDLCQPTQ KKYQIAVTKV LGKNMDAIIV DSEKTGRDCI QYIKEQRGEP
ETFLPLDYLE VKPTDEKLRE LKGAKLVIDV IRYEPPHIKK ALQYACGNAL VCDNVEDARR
IAFGGHQRHK TVALDGTLFQ KSGVISGGAS DLKAKARRWD EKAVDKLKEK KERLTEELKE
QMKAKRKEAE LRQVQSQAHG LQMRLKYSQS DLEQTKTRHL ALNLQLEFEN QKTRLGIQLD
FEKNQLKEDQ DKVHMWEQTV KKDENEIEKL KKEEQRHMKI IDETMAQLQD LKNQHLAKKS
EVNDKNHEME EIRKKLGGAN KEMTHLQKEV TAIETKLEQK RSDRHNLLQA CKMQDIKLPL
SKGTMDDISQ EEGSSQGEDS VSGSQRTSSI YAREALIEID YGDLCEDLKD AQAEEEIKQE
MNTLQQKLNE QQSVLQRIAA PNMKAMEKLE SVRDKFQETS DEFEAARKRA KKAKQAFEQI
KKERFDRFNA CFESVATNID EIYKALSRNS SAQAFLGPEN PEEPYLDGIN YNCVAPGKRF
RPMDNLSGGE KTVAALALLF AIHSYKPAPF FVLDEIDAAL DNTNIGKVAN YIKEQSTCNF
QAIVISLKEE FYTKAESLIG VYPEQGDCVI SKVLTFDLTK YPDANPNPNE Q
//
