ID G1SN86_RABIT Unreviewed; 1670 AA.
AC G1SN86;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=NEDD4 binding protein 2 {ECO:0000313|Ensembl:ENSOCUP00000004432.4};
GN Name=N4BP2 {ECO:0000313|Ensembl:ENSOCUP00000004432.4};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000004432.4, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000004432.4, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000004432.4,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000004432.4}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000004432.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAGW02010662; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02010663; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02010664; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02010665; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02010666; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR SMR; G1SN86; -.
DR STRING; 9986.ENSOCUP00000004432; -.
DR PaxDb; 9986-ENSOCUP00000004432; -.
DR Ensembl; ENSOCUT00000005119.4; ENSOCUP00000004432.4; ENSOCUG00000005111.4.
DR eggNOG; KOG2401; Eukaryota.
DR GeneTree; ENSGT00940000160604; -.
DR HOGENOM; CLU_002599_0_0_1; -.
DR InParanoid; G1SN86; -.
DR TreeFam; TF327016; -.
DR Proteomes; UP000001811; Chromosome 2.
DR Bgee; ENSOCUG00000005111; Expressed in autopod skin and 16 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005524; F:ATP binding; IEA:Ensembl.
DR GO; GO:0046404; F:ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity; IEA:Ensembl.
DR GO; GO:0004520; F:DNA endonuclease activity; IEA:Ensembl.
DR GO; GO:0043130; F:ubiquitin binding; IEA:InterPro.
DR CDD; cd14365; CUE_N4BP2; 1.
DR Gene3D; 3.30.1370.110; -; 1.
DR Gene3D; 1.10.8.10; DNA helicase RuvA subunit, C-terminal domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003892; CUE.
DR InterPro; IPR013899; DUF1771.
DR InterPro; IPR041801; N4BP2_CUE.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR002625; Smr_dom.
DR InterPro; IPR036063; Smr_dom_sf.
DR InterPro; IPR009060; UBA-like_sf.
DR PANTHER; PTHR46535; NEDD4-BINDING PROTEIN 2; 1.
DR PANTHER; PTHR46535:SF1; NEDD4-BINDING PROTEIN 2; 1.
DR Pfam; PF13671; AAA_33; 1.
DR Pfam; PF08590; DUF1771; 1.
DR Pfam; PF01713; Smr; 1.
DR SMART; SM01162; DUF1771; 1.
DR SMART; SM00463; SMR; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF160443; SMR domain-like; 1.
DR SUPFAM; SSF46934; UBA-like; 1.
DR PROSITE; PS51140; CUE; 1.
DR PROSITE; PS50828; SMR; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001811}.
FT DOMAIN 46..89
FT /note="CUE"
FT /evidence="ECO:0000259|PROSITE:PS51140"
FT DOMAIN 1591..1670
FT /note="Smr"
FT /evidence="ECO:0000259|PROSITE:PS50828"
FT REGION 177..200
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 692..759
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 771..860
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1164..1217
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1483..1510
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 698..721
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 722..754
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 801..829
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 830..855
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1166..1208
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1487..1507
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1670 AA; 186628 MW; AD0F4AEA5E2B7714 CRC64;
MPRKRRNLGG NPFRKTANPK EVVVSGVASH EEPTTALPSI CETKIDQEEL FTSMSEMFSD
LDPDVVYLML SECDFKVENA MDCLLELSAT DAKIEESTSQ SFVVPENQVS AAGSGIMEKY
PLEEESEDSK MDSFLDMQLT EDLDSLIQNA FEKLNSSSDD QLYSFLPLQD VNSLNGPREF
INSDSNNMTP IPSTQNVDSD RENLENSAST LSSNTLTSHM ALNEPKSFTK DSILALEDNY
PEDSVLNSSL NLASDSIVDC STLNQRQNEL LESECVETQF CQTLLESDAN ELKAPLNLPV
QNPGLDIPGT GGDQKPTSVS DVFVSPEGFN FKPHKHTELP PKGKDVNYCP VLTPLPLLLP
PPPPPPMWNP MIPAFDLFQG NHGFVAPVVT TAAHWRPVNY TFPPSIISHP SPTKIWRNKE
GTSAYQVQET PVSQTVRKKT TSYVGLVLVL LRGLPGSGKS YLARTLQEDN PNGVILSTDD
YFYINGQYQF DVKYLGEAHE WNQNRAKEAF EKKVSPVIID NTNLQAWEMK PYVAMSQKHK
YKVLFREPDT WWKFKPKELA RRNIHGVSKE KITRMLEHYQ RFVSVPIIMS SLAPEKIERI
ELCAYSCEDG IPSSRISDDT TSDKEENVLS SPLRHLELIE HKTLEVTKGT TLPEDVPHLL
SADLNREGKE ISAMNTQGAF IQETSHMHCS ASESKLGTTD KSENEEQVET MSEKECSTTD
VDSSIERVSS NSCYDESNQE DCDPANTVPL QNEKSSPDEI LEERATVKKK AFAKQKSKST
LEKFPRQELP NFVGDWPVDK TMGQRTKRNR KTEKASYVQS DRKFSRPQSR KVSDSSVSVN
TDPTQQGGSS HECTGDGRKS QCDDASESFH SCKYETYQNT ESNSFNVVGD WPSPESLAQR
EHRSRMPRSG LNELNPDFGT NDDVNEISLY TAREACWETS PELKTFGSCT LGSSEMLPSE
VSCETQTCGE HSLPFTFTSS ASALPAVVGP QTVAEFSEGM PKGVPGIEVG VCTQTEPQDF
ALLWKIEKNK IGVSDSIKVL TGRLDGFKPK TFNINTKADV QETIPYRVMY DKSTYVEESE
LTSADESENL NILCKLFGSF SLEALKDLYE RCNKDIIWAT SLLLDSETKL CEDTEFENFQ
KSCDESQIGP FSLGLNLKEI ISQRGAEEDS NSSAPEFSHG VGVSNTNTQS PGDAERENSE
QAEISTTTPE KPGLAMGMFP SAAVDAKSND EILPNSQVEL PSLYNFKPSL PAVLKAASSE
DVSETDNSLV ATETGENVHS SLNLSDILNS ISNTSNLEGI DSGSLTVEDC VVHIDLNLAK
VIHEKWKESV MERQRQEEVS SGRLMRDPSL VGQIGLDNPE QKSSQRTGKK LLKTLAASEM
LPLMDHWNTQ TKKVSLREIM SEEIALQEKH DLKRETFIFE KDCATKLKEK QLFKIFPAIN
QNFLVDIFKD HNYSLEHTVQ FLNCVLEGDP VKTVVAQEFV HQNEQSTAQK SKEKKVKKPK
ETEDIPSEPS FQDFEYPEYD DYRAEAFLHQ QKRTECYSKA KEAYRMGKKN VATFYAQQGS
LHERKMKEAN HLAAVEIFEK VNASLLPQNV LDLHGLHVDE AIEHLMTVLQ QKTEECKQSG
GKPYLSVITG RGNHSQGGVA RIKPAVIKYL TSHNFRFSEI KPGCLKVMLK
//
