ID G1SNN5_RABIT Unreviewed; 687 AA.
AC G1SNN5;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 57.
DE SubName: Full=Interleukin 17 receptor E {ECO:0000313|Ensembl:ENSOCUP00000004607.4};
GN Name=IL17RE {ECO:0000313|Ensembl:ENSOCUP00000004607.4};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000004607.4, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000004607.4, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke {ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000004607.4}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000004607.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
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DR AlphaFoldDB; G1SNN5; -.
DR PaxDb; 9986-ENSOCUP00000004607; -.
DR Ensembl; ENSOCUT00000005312.4; ENSOCUP00000004607.4; ENSOCUG00000005311.4.
DR eggNOG; ENOG502QU0I; Eukaryota.
DR GeneTree; ENSGT00940000161421; -.
DR HOGENOM; CLU_026094_0_0_1; -.
DR TreeFam; TF335690; -.
DR Proteomes; UP000001811; Unplaced.
DR Bgee; ENSOCUG00000005311; Expressed in skin of back and 12 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0030368; F:interleukin-17 receptor activity; IEA:InterPro.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.11530; -; 1.
DR InterPro; IPR039465; IL-17_rcpt-like.
DR InterPro; IPR027841; IL-17_rcpt_C/E_N.
DR InterPro; IPR013568; SEFIR_dom.
DR PANTHER; PTHR15583; INTERLEUKIN-17 RECEPTOR; 1.
DR PANTHER; PTHR15583:SF5; INTERLEUKIN-17 RECEPTOR E; 1.
DR Pfam; PF15037; IL17_R_N; 2.
DR Pfam; PF08357; SEFIR; 1.
PE 4: Predicted;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Inflammatory response {ECO:0000256|ARBA:ARBA00023198};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 478..498
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 125..247
FT /note="Interleukin-17 receptor C/E N-terminal"
FT /evidence="ECO:0000259|Pfam:PF15037"
FT DOMAIN 245..470
FT /note="Interleukin-17 receptor C/E N-terminal"
FT /evidence="ECO:0000259|Pfam:PF15037"
FT DOMAIN 511..583
FT /note="SEFIR"
FT /evidence="ECO:0000259|Pfam:PF08357"
FT REGION 177..197
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 687 AA; 75088 MW; 2D1E4A5BFFBC2B1C CRC64;
MLAPFLSFFS HTRAPSSFRP RSHVPCALTL QKPMGSPGWA PLLLLAVGLC ASGGIVCSRS
PCWSTHGLLA LHTESSFTGS PACAPCSTLL ALLPGRLRLV PVWHLRVASD ASGLQRGCFC
LSAWKSRKSY TFRFCRRPRM PAPAQRKLLG RRCLSGKGRH VSVPCLDTCP RGLRSKRTQP
WDPFSAARGP GLGSQRRGGP DFSFELLPEA RVIRATVPPG PEVLLRLCHQ WALECEEPSS
PFDAQKIVSG GHTADLPYEF LLPCLCIEAF HLQEDTVRRK KCPFQSWPEA YGSDFWKSVH
FSDYSQRDQM AMALTLRCPL RLEASLCQKQ EGHTLCEDVP NATARESEGW YILDKVDLHP
QLCFKFSVGN SSHVECPHQT GACTSWNVSM DTRARQLILH FSSTVQATFS AAWSHPGLGH
DPLTSPVYSV SQTQGSGPVT LDLVIPFLRP GGCVLVWRSD VQFASKRLLC PDVSHRRLGL
LILALLALAT LLGVVLVLTC CHPLSGPGPA RPVLLLHVAE SQEQRRLVGA LAELLRTALG
GGRDVIVDLW EGTRVAHVGP LPWLWAAQAR VLRERGTVLL LWGPAGGSDP CTAPLHALLG
AAPRPLLLLA YFSRLCAKGD IPRPLRVLPR YRLLRDLPRL LRALGARPGT GTVAAGPDCL
GARQGLRGRL ELCRRLEREA ATVAGHV
//
