ID G1SPF5_RABIT Unreviewed; 129 AA.
AC G1SPF5;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 71.
DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOCUP00000004921.3};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000004921.3, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000004921.3, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000004921.3,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000004921.3}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000004921.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738}.
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DR EMBL; AAGW02060703; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02060704; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02060705; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02060706; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02060707; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02060708; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02060709; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02060710; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02060711; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02060712; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1SPF5; -.
DR SMR; G1SPF5; -.
DR STRING; 9986.ENSOCUP00000004921; -.
DR PaxDb; 9986-ENSOCUP00000004921; -.
DR Ensembl; ENSOCUT00000005676.3; ENSOCUP00000004921.3; ENSOCUG00000005679.3.
DR eggNOG; KOG0235; Eukaryota.
DR GeneTree; ENSGT00950000182926; -.
DR HOGENOM; CLU_033323_1_1_1; -.
DR InParanoid; G1SPF5; -.
DR TreeFam; TF300007; -.
DR Proteomes; UP000001811; Chromosome 18.
DR Bgee; ENSOCUG00000005679; Expressed in frontal cortex and 18 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0004619; F:phosphoglycerate mutase activity; IEA:Ensembl.
DR GO; GO:0006094; P:gluconeogenesis; IEA:Ensembl.
DR GO; GO:0006096; P:glycolytic process; IEA:InterPro.
DR CDD; cd07067; HP_PGM_like; 1.
DR Gene3D; 3.40.50.1240; Phosphoglycerate mutase-like; 1.
DR InterPro; IPR013078; His_Pase_superF_clade-1.
DR InterPro; IPR029033; His_PPase_superfam.
DR InterPro; IPR005952; Phosphogly_mut1.
DR NCBIfam; TIGR01258; pgm_1; 1.
DR PANTHER; PTHR11931; PHOSPHOGLYCERATE MUTASE; 1.
DR PANTHER; PTHR11931:SF15; PHOSPHOGLYCERATE MUTASE 1; 1.
DR Pfam; PF00300; His_Phos_1; 1.
DR SUPFAM; SSF53254; Phosphoglycerate mutase-like; 1.
PE 4: Predicted;
KW Glycolysis {ECO:0000256|ARBA:ARBA00023152};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811}.
FT BINDING 62..63
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR613078-2"
FT SITE 61
FT /note="Transition state stabilizer"
FT /evidence="ECO:0000256|PIRSR:PIRSR613078-3"
SQ SEQUENCE 129 AA; 14526 MW; 906D6CF2DC95CC37 CRC64;
MEPDHPFYSN ISKDRRYADL TEDQLPSCES LKDTIARALP FWNEEIVPQI KEGKRVLIAA
HGNSLRGIVK HLEGLSEEAI MELNLPTGIP IVYELDKNLK PIKPMQFLGD EETVRKAMEA
VAAQGKAKK
//
