ID G1SPL8_RABIT Unreviewed; 151 AA.
AC G1SPL8; A0A1K0FUC6;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 24-JAN-2024, entry version 64.
DE RecName: Full=Neuroglobin {ECO:0000256|ARBA:ARBA00040609};
GN Name=GLNH {ECO:0000313|EMBL:SAI82240.1};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000004997.3, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000004997.3, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000004997.3,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|EMBL:SAI82240.1}
RP NUCLEOTIDE SEQUENCE.
RX DOI=10.1016/j.genrep.2016.10.009;
RA Premzl M.;
RT "Comparative genomic analysis of eutherian globin genes.";
RL Gene Rep 5:163-166(2016).
RN [3] {ECO:0000313|EMBL:SAI82240.1}
RP NUCLEOTIDE SEQUENCE.
RX DOI=10.1016/j.genrep.2019.100414;
RA Premzl M.;
RT "Eutherian third-party data gene collections.";
RL Gene Rep 16:100414-100414(2019).
RN [4] {ECO:0000313|Ensembl:ENSOCUP00000004997.3}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000004997.3};
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the globin family.
CC {ECO:0000256|ARBA:ARBA00008705, ECO:0000256|PROSITE-ProRule:PRU00238,
CC ECO:0000256|RuleBase:RU000356}.
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DR EMBL; AAGW02049171; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; LT548190; SAI82240.1; -; Genomic_DNA.
DR RefSeq; XP_008270116.1; XM_008271894.2.
DR Ensembl; ENSOCUT00000005766.3; ENSOCUP00000004997.3; ENSOCUG00000005776.4.
DR GeneID; 100008868; -.
DR CTD; 58157; -.
DR GeneTree; ENSGT00940000156829; -.
DR HOGENOM; CLU_003827_13_5_1; -.
DR OrthoDB; 2015093at2759; -.
DR TreeFam; TF333247; -.
DR Proteomes; UP000001811; Chromosome 20.
DR Bgee; ENSOCUG00000005776; Expressed in testis and 18 other cell types or tissues.
DR ExpressionAtlas; G1SPL8; baseline.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0019825; F:oxygen binding; IEA:InterPro.
DR GO; GO:0005344; F:oxygen carrier activity; IEA:UniProtKB-KW.
DR CDD; cd08920; Ngb; 1.
DR Gene3D; 1.10.490.10; Globins; 1.
DR InterPro; IPR000971; Globin.
DR InterPro; IPR009050; Globin-like_sf.
DR InterPro; IPR012292; Globin/Proto.
DR PANTHER; PTHR46458; BLR2807 PROTEIN; 1.
DR PANTHER; PTHR46458:SF19; NEUROGLOBIN; 1.
DR Pfam; PF00042; Globin; 1.
DR SUPFAM; SSF46458; Globin-like; 1.
DR PROSITE; PS01033; GLOBIN; 1.
PE 3: Inferred from homology;
KW Heme {ECO:0000256|ARBA:ARBA00022617, ECO:0000256|PROSITE-ProRule:PRU00238};
KW Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|PROSITE-ProRule:PRU00238};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|PROSITE-
KW ProRule:PRU00238};
KW Oxygen transport {ECO:0000256|ARBA:ARBA00022621, ECO:0000256|PROSITE-
KW ProRule:PRU00238}; Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|PROSITE-
KW ProRule:PRU00238}.
FT DOMAIN 5..144
FT /note="Globin family profile"
FT /evidence="ECO:0000259|PROSITE:PS01033"
FT BINDING 64
FT /ligand="heme b"
FT /ligand_id="ChEBI:CHEBI:60344"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="distal binding residue"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00238"
FT BINDING 96
FT /ligand="heme b"
FT /ligand_id="ChEBI:CHEBI:60344"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="proximal binding residue"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00238"
SQ SEQUENCE 151 AA; 17012 MW; A0C8347C7D1F9F2D CRC64;
MERPEQELIR QSWRAVSRSP LEHGTVLFAR LFDLEPDLLP LFQYNCRQFS SPEDCLSSPE
FLDHIRKVML VIDAAVTNVE DLSSLEEYLA GLGRKHRAVG VKFSSFSTVG ESLLYMLEKC
LGPAFTPATR AAWSQLYGAV VQAMSRGWDG E
//