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Database: UniProt
Entry: G1SPQ4_RABIT
LinkDB: G1SPQ4_RABIT
Original site: G1SPQ4_RABIT 
ID   G1SPQ4_RABIT            Unreviewed;       224 AA.
AC   G1SPQ4;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   16-OCT-2019, entry version 43.
DE   RecName: Full=RING-type domain-containing protein {ECO:0000259|PROSITE:PS50089};
GN   Name=RNF186 {ECO:0000313|Ensembl:ENSOCUP00000005038};
OS   Oryctolagus cuniculus (Rabbit).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae;
OC   Oryctolagus.
OX   NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000005038, ECO:0000313|Proteomes:UP000001811};
RN   [1] {ECO:0000313|Ensembl:ENSOCUP00000005038, ECO:0000313|Proteomes:UP000001811}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Thorbecke {ECO:0000313|Proteomes:UP000001811};
RX   PubMed=21993624; DOI=10.1038/nature10530;
RA   Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J.,
RA   Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E.,
RA   Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J.,
RA   Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S.,
RA   Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I.,
RA   Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I.,
RA   Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J.,
RA   Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D.,
RA   Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L.,
RA   Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S.,
RA   Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G.,
RA   Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K.,
RA   Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T.,
RA   Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J.,
RA   Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S.,
RA   Pedersen J.S., Lander E.S., Kellis M.;
RT   "A high-resolution map of human evolutionary constraint using 29
RT   mammals.";
RL   Nature 478:476-482(2011).
RN   [2] {ECO:0000313|Ensembl:ENSOCUP00000005038}
RP   IDENTIFICATION.
RC   STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000005038};
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
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DR   EMBL; AAGW02059960; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_008264002.1; XM_008265780.2.
DR   STRING; 9986.ENSOCUP00000005038; -.
DR   Ensembl; ENSOCUT00000005813; ENSOCUP00000005038; ENSOCUG00000005813.
DR   GeneID; 100344925; -.
DR   KEGG; ocu:100344925; -.
DR   CTD; 54546; -.
DR   eggNOG; KOG2177; Eukaryota.
DR   eggNOG; ENOG4111G04; LUCA.
DR   GeneTree; ENSGT00510000049175; -.
DR   InParanoid; G1SPQ4; -.
DR   OMA; KLLGCQH; -.
DR   OrthoDB; 1446732at2759; -.
DR   TreeFam; TF331690; -.
DR   Proteomes; UP000001811; Chromosome 13.
DR   Bgee; ENSOCUG00000005813; Expressed in 2 organ(s), highest expression level in adult mammalian kidney.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:Ensembl.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:InterPro.
DR   GO; GO:0070059; P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; IEA:Ensembl.
DR   GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IEA:Ensembl.
DR   GO; GO:0051865; P:protein autoubiquitination; IEA:Ensembl.
DR   GO; GO:0035519; P:protein K29-linked ubiquitination; IEA:Ensembl.
DR   GO; GO:0070534; P:protein K63-linked ubiquitination; IEA:Ensembl.
DR   GO; GO:0070585; P:protein localization to mitochondrion; IEA:Ensembl.
DR   Gene3D; 3.30.40.10; -; 1.
DR   InterPro; IPR038878; RNF186.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   InterPro; IPR017907; Znf_RING_CS.
DR   PANTHER; PTHR22791:SF12; PTHR22791:SF12; 1.
DR   Pfam; PF14634; zf-RING_5; 1.
DR   SMART; SM00184; RING; 1.
DR   PROSITE; PS00518; ZF_RING_1; 1.
DR   PROSITE; PS50089; ZF_RING_2; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001811};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00175};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Zinc {ECO:0000256|PROSITE-ProRule:PRU00175};
KW   Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00175}.
FT   TRANSMEM    156    175       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    181    199       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       41     87       RING-type. {ECO:0000259|PROSITE:PS50089}.
SQ   SEQUENCE   224 AA;  23684 MW;  D50580FEA7004854 CRC64;
     MACAEGLQQP QAVLAGATTT AVAAAGLSRG PPGSVECELE CLVCREPYSF ARSPKLLSCQ
     HTFCAVCLKL LLCVQEDAWS ITCPLCRKLT AVPGGLIGSL RNQEEVVGWL SQPCREVQLC
     PQELTGPAAS ATALPSSVGE DGPGTVSANR VAARRLAAHL LLLALLIFVI LPFIYPGVIR
     WVLALIIALA LLMSLLFCCH PHSLGTPRTL FCGEQKHSEI ASIA
//
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