ID G1SPT4_RABIT Unreviewed; 147 AA.
AC G1SPT4;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 60.
DE RecName: Full=DNA polymerase epsilon subunit 3 {ECO:0000256|ARBA:ARBA00039793};
DE AltName: Full=DNA polymerase II subunit 3 {ECO:0000256|ARBA:ARBA00042098};
GN Name=POLE3 {ECO:0000313|Ensembl:ENSOCUP00000005070.3};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000005070.3, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000005070.3, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke {ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000005070.3}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000005070.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR RefSeq; XP_002720466.1; XM_002720420.3.
DR RefSeq; XP_008271636.1; XM_008273414.2.
DR AlphaFoldDB; G1SPT4; -.
DR SMR; G1SPT4; -.
DR STRING; 9986.ENSOCUP00000005070; -.
DR PaxDb; 9986-ENSOCUP00000005070; -.
DR Ensembl; ENSOCUT00000005852.3; ENSOCUP00000005070.3; ENSOCUG00000005854.3.
DR GeneID; 100355895; -.
DR KEGG; ocu:100355895; -.
DR CTD; 54107; -.
DR eggNOG; KOG0870; Eukaryota.
DR GeneTree; ENSGT00940000161417; -.
DR HOGENOM; CLU_066247_7_4_1; -.
DR InParanoid; G1SPT4; -.
DR OrthoDB; 103569at2759; -.
DR TreeFam; TF103008; -.
DR Proteomes; UP000001811; Unplaced.
DR Bgee; ENSOCUG00000005854; Expressed in autopod skin and 17 other cell types or tissues.
DR GO; GO:0140672; C:ATAC complex; IEA:Ensembl.
DR GO; GO:0008622; C:epsilon DNA polymerase complex; IEA:Ensembl.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR GO; GO:0006261; P:DNA-templated DNA replication; IEA:Ensembl.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0006334; P:nucleosome assembly; IEA:Ensembl.
DR GO; GO:0006275; P:regulation of DNA replication; IEA:Ensembl.
DR Gene3D; 1.10.20.10; Histone, subunit A; 1.
DR InterPro; IPR003958; CBFA_NFYB_domain.
DR InterPro; IPR009072; Histone-fold.
DR PANTHER; PTHR46172; DNA POLYMERASE EPSILON SUBUNIT 3; 1.
DR PANTHER; PTHR46172:SF1; DNA POLYMERASE EPSILON SUBUNIT 3; 1.
DR Pfam; PF00808; CBFD_NFYB_HMF; 1.
DR SUPFAM; SSF47113; Histone-fold; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001811}.
FT DOMAIN 9..73
FT /note="Transcription factor CBF/NF-Y/archaeal histone"
FT /evidence="ECO:0000259|Pfam:PF00808"
FT REGION 93..147
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 93..120
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 121..147
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 147 AA; 16825 MW; C1CB8A5A3DAC8469 CRC64;
MAERPEDLNL PNAVITRIIK EALPEGVNIS KEARSAISRA ASVFVLYATS CANNFAMKGK
RKTLNASDVL SAMEEMEFQR FVAPLKEALE AYRREQRGKK EASEQKKKDK DKKADSEEPD
KSRDEDNDED EERLEEEEQN EEEEIDN
//
