ID G1SQ44_RABIT Unreviewed; 439 AA.
AC G1SQ44;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 2.
DT 27-MAR-2024, entry version 58.
DE SubName: Full=Acyl-CoA thioesterase 4 {ECO:0000313|Ensembl:ENSOCUP00000005198.3};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000005198.3, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000005198.3, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000005198.3,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000005198.3}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000005198.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the C/M/P thioester hydrolase family.
CC {ECO:0000256|ARBA:ARBA00006538}.
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DR EMBL; AAGW02049260; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02049261; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02049262; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_002719710.2; XM_002719664.3.
DR AlphaFoldDB; G1SQ44; -.
DR MEROPS; S09.A51; -.
DR PaxDb; 9986-ENSOCUP00000005198; -.
DR Ensembl; ENSOCUT00000006004.4; ENSOCUP00000005198.3; ENSOCUG00000022543.3.
DR GeneID; 100344509; -.
DR KEGG; ocu:100344509; -.
DR eggNOG; ENOG502QQ8Z; Eukaryota.
DR GeneTree; ENSGT01010000222336; -.
DR HOGENOM; CLU_029849_4_0_1; -.
DR OMA; CHATRIY; -.
DR OrthoDB; 5356064at2759; -.
DR TreeFam; TF314911; -.
DR Proteomes; UP000001811; Chromosome 20.
DR Bgee; ENSOCUG00000022543; Expressed in liver and 17 other cell types or tissues.
DR ExpressionAtlas; G1SQ44; baseline.
DR GO; GO:0016790; F:thiolester hydrolase activity; IEA:InterPro.
DR GO; GO:0006637; P:acyl-CoA metabolic process; IEA:InterPro.
DR GO; GO:0006631; P:fatty acid metabolic process; IEA:UniProtKB-KW.
DR Gene3D; 2.60.40.2240; Acyl-CoA thioester hydrolase/BAAT N-terminal domain; 1.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR016662; Acyl-CoA_thioEstase_long-chain.
DR InterPro; IPR014940; BAAT_C.
DR InterPro; IPR006862; Thio_Ohase/aa_AcTrfase.
DR InterPro; IPR042490; Thio_Ohase/BAAT_N.
DR PANTHER; PTHR10824:SF16; ACYL-COENZYME A THIOESTERASE 1-RELATED; 1.
DR PANTHER; PTHR10824; ACYL-COENZYME A THIOESTERASE-RELATED; 1.
DR Pfam; PF08840; BAAT_C; 1.
DR Pfam; PF04775; Bile_Hydr_Trans; 1.
DR PIRSF; PIRSF016521; Acyl-CoA_hydro; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE 3: Inferred from homology;
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811}.
FT DOMAIN 41..165
FT /note="Acyl-CoA thioester hydrolase/bile acid-CoA amino
FT acid N-acetyltransferase"
FT /evidence="ECO:0000259|Pfam:PF04775"
FT DOMAIN 229..436
FT /note="BAAT/Acyl-CoA thioester hydrolase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF08840"
FT ACT_SITE 257
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR016521-1"
FT ACT_SITE 351
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR016521-1"
FT ACT_SITE 385
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR016521-1"
SQ SEQUENCE 439 AA; 47662 MW; 250022D4671C3F7D CRC64;
MERGQARPTA HDSPKQGRLF VAQVGMAATV SVEPAGPCCW DEPVRIAVRG LAPEQPVTLR
ASLRDEKGAL FRAHARYCAD AGGQLDLARA PALGGSFAGL EPMGLLWALQ PDRPFWRLTK
RDVQTPLAVE LEVLDGHAPE PGQLLARALL ERRFLPPGVR RQPVRAGRVR ATLFLPPGPG
PFPGIVDMFG VGGGLLEYRA SLLAGKGFAV MALAYYNYDD LPKSMDTLHL EYFEEAVNYL
ISRPEVKGPG IGLLGHSKGG ELGLTMTSFL KGITAAVIIN GSIVNVGGTL HYKDVTLPPI
GANRSRIKMT KEGFADIVDA LNSPLEGPDQ KSLIPVERSE CTFLFLVGQD DHNWKSEFYA
NEASKRLQAQ GKAKPQIICY PEAGHYIEPP YFPLCRASLH ALVGGPVFWG GEPRAHAVAQ
VDAWKQLQTF FHKHLGGES
//
