ID G1SR04_RABIT Unreviewed; 630 AA.
AC G1SR04;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=SHC adaptor protein 4 {ECO:0000313|Ensembl:ENSOCUP00000005567.2};
GN Name=SHC4 {ECO:0000313|Ensembl:ENSOCUP00000005567.2};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000005567.2, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000005567.2, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000005567.2,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000005567.2}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000005567.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAGW02024717; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02024718; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_008267264.1; XM_008269042.2.
DR AlphaFoldDB; G1SR04; -.
DR SMR; G1SR04; -.
DR STRING; 9986.ENSOCUP00000005567; -.
DR PaxDb; 9986-ENSOCUP00000005567; -.
DR Ensembl; ENSOCUT00000006439.4; ENSOCUP00000005567.2; ENSOCUG00000006438.4.
DR GeneID; 100350676; -.
DR KEGG; ocu:100350676; -.
DR CTD; 399694; -.
DR eggNOG; KOG3697; Eukaryota.
DR GeneTree; ENSGT00950000182870; -.
DR HOGENOM; CLU_029532_2_0_1; -.
DR InParanoid; G1SR04; -.
DR OMA; QLRSEDC; -.
DR OrthoDB; 2903566at2759; -.
DR TreeFam; TF315807; -.
DR Proteomes; UP000001811; Chromosome 17.
DR Bgee; ENSOCUG00000006438; Expressed in testis and 15 other cell types or tissues.
DR GO; GO:0019904; F:protein domain specific binding; IEA:Ensembl.
DR GO; GO:0030971; F:receptor tyrosine kinase binding; IEA:Ensembl.
DR GO; GO:0006915; P:apoptotic process; IEA:Ensembl.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IEA:Ensembl.
DR GO; GO:0010468; P:regulation of gene expression; IEA:Ensembl.
DR GO; GO:0048863; P:stem cell differentiation; IEA:Ensembl.
DR CDD; cd01209; PTB_Shc; 1.
DR CDD; cd09925; SH2_SHC; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR006019; PID_Shc-like.
DR InterPro; IPR006020; PTB/PI_dom.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR035676; SHC_SH2.
DR PANTHER; PTHR10337; SHC TRANSFORMING PROTEIN; 1.
DR PANTHER; PTHR10337:SF12; SHC-TRANSFORMING PROTEIN 4; 1.
DR Pfam; PF00640; PID; 1.
DR Pfam; PF00017; SH2; 1.
DR PRINTS; PR00401; SH2DOMAIN.
DR PRINTS; PR00629; SHCPIDOMAIN.
DR SMART; SM00462; PTB; 1.
DR SMART; SM00252; SH2; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR PROSITE; PS01179; PID; 1.
DR PROSITE; PS50001; SH2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191}.
FT DOMAIN 189..349
FT /note="PID"
FT /evidence="ECO:0000259|PROSITE:PS01179"
FT DOMAIN 526..617
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT REGION 38..79
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 119..176
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 477..514
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 609..630
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 38..52
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 122..142
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 630 AA; 68422 MW; 245AC48CA4770406 CRC64;
MRERGQDCPA GLVLCVGLFG HPGMLHRAKY SRFRNESITS LDEGSPGGSV GNKGSPQPPC
PALAPHLPAE DATLPSQESP TPLCTLIPRM ASMKLANPAT LLSLKNFCLG TKEVPRLKLQ
ESQDPAPSSP ASPETSLSRA GSAPPPQPDL LGHRATALTP NACPLPGPGE PAPRPRQDKQ
YLQHLLGMGM NYCVRYMGCI EVLQSMRSLD FGMRTQVTRE AISRLCEAVP GANGAIKKRK
PPVKFLSTVL GKSNLQFSGT NIKLTISTCS LTLMNLDNQQ IIANHHMQSI SFASGGDPDT
TDYVAYVAKD PVNQRACHIL ECRSGMAQDV ISTIGQAFEL RFKQYLKNPS LNASCESEEV
HIDGPAEERE GPEYYNEIPG KQPPAGGVSD VRAKVQATEQ MAYCPIRCEK LCYLPGNSKC
SSVYENCLEQ SRAIGNTHER GVPFPREASL MKHTCRVDLF DDPCYINTQA LQSTLGCARD
QSSGQPPGNS WHRGKTPETV QPGATAQPAS SHSLPHIKQQ LWNEECYHGK LSRKAAESLL
VKDGDFLVRE SATSPGQYVL SGLQGGQAKH LLLVDPEGKV RTKDHVFDNV GHLIRYHMDN
SLPIVSSGSE VSLKQPVRKD NTPGLLQSKK
//
