ID G1SRI4_RABIT Unreviewed; 395 AA.
AC G1SRI4;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE SubName: Full=Methyltransferase like 22 {ECO:0000313|Ensembl:ENSOCUP00000005786.2};
GN Name=METTL22 {ECO:0000313|Ensembl:ENSOCUP00000005786.2};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000005786.2, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000005786.2, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000005786.2,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000005786.2}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000005786.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAGW02056892; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_002711790.1; XM_002711744.3.
DR RefSeq; XP_008255909.1; XM_008257687.2.
DR RefSeq; XP_008255910.1; XM_008257688.2.
DR RefSeq; XP_017197929.1; XM_017342440.1.
DR AlphaFoldDB; G1SRI4; -.
DR PaxDb; 9986-ENSOCUP00000005786; -.
DR Ensembl; ENSOCUT00000006695.4; ENSOCUP00000005786.2; ENSOCUG00000006701.4.
DR GeneID; 100347142; -.
DR KEGG; ocu:100347142; -.
DR CTD; 79091; -.
DR eggNOG; KOG2497; Eukaryota.
DR GeneTree; ENSGT00510000048539; -.
DR HOGENOM; CLU_048361_0_0_1; -.
DR OMA; AYERIQQ; -.
DR OrthoDB; 450395at2759; -.
DR TreeFam; TF324844; -.
DR Proteomes; UP000001811; Chromosome 6.
DR Bgee; ENSOCUG00000006701; Expressed in testis and 17 other cell types or tissues.
DR GO; GO:0008276; F:protein methyltransferase activity; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR019410; Methyltransf_16.
DR InterPro; IPR038899; METTL22.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR23108:SF0; METHYLTRANSFERASE-LIKE PROTEIN 22; 1.
DR PANTHER; PTHR23108; METHYLTRANSFERASE-RELATED; 1.
DR Pfam; PF10294; Methyltransf_16; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022603}.
FT REGION 58..137
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 82..103
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 109..130
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 395 AA; 43343 MW; 5273A73BDF2285C0 CRC64;
MVQLVPAPAM DEITFRSDTV LSDVHLYTPN HRHLMVRLNG VGQPVFLSQF KLLWSRDSQT
EPGAESGGHS HVHAEGTPPG SGCTDEGSSL SPGAGTTSQE GAGAQLDEDG DLDVERRPRA
TSDPDPAEPP RDKVQPVVLA QEEDDGPGDE AWDGSALGVI RIEHTMATPL EDVGKQVWRG
ALLLADYILF RRDLFQGRTV LELGAGTGLA SVVAATVART VYCTDVGADL LSMCQRNIAL
NSHLAAPGGG TVKVKELDWL KDDLCTDPEV PFSWSEEDVC DLYAHTTVLL AAEVFYDDDL
TDALFKTLSR LAHRFHNACT AILAVEKRLN FTLRHLDVTC EAYDHFRASL QALQRLPDSR
LRFVVEPVEA SFPQLLLYER IRQLELWKII AEPVT
//
