ID G1SS49_RABIT Unreviewed; 259 AA.
AC G1SS49;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE RecName: Full=Haloacid dehalogenase-like hydrolase domain-containing protein 2 {ECO:0000256|ARBA:ARBA00039666};
GN Name=HDHD2 {ECO:0000313|Ensembl:ENSOCUP00000006037.2};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000006037.2, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000006037.2, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000006037.2,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000006037.2}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000006037.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SIMILARITY: Belongs to the HAD-like hydrolase superfamily.
CC {ECO:0000256|ARBA:ARBA00007958}.
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DR EMBL; AAGW02032341; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02032342; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02032343; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_002713564.1; XM_002713518.3.
DR RefSeq; XP_008259493.1; XM_008261271.1.
DR RefSeq; XP_008259494.1; XM_008261272.2.
DR RefSeq; XP_008259495.1; XM_008261273.2.
DR RefSeq; XP_008259496.1; XM_008261274.2.
DR AlphaFoldDB; G1SS49; -.
DR PaxDb; 9986-ENSOCUP00000006037; -.
DR Ensembl; ENSOCUT00000006979.4; ENSOCUP00000006037.2; ENSOCUG00000006979.4.
DR eggNOG; KOG3040; Eukaryota.
DR GeneTree; ENSGT00940000155805; -.
DR HOGENOM; CLU_043473_4_0_1; -.
DR OMA; PNPYFFE; -.
DR OrthoDB; 2876640at2759; -.
DR TreeFam; TF314344; -.
DR Proteomes; UP000001811; Chromosome 9.
DR Bgee; ENSOCUG00000006979; Expressed in heart and 18 other cell types or tissues.
DR GO; GO:0016791; F:phosphatase activity; IEA:InterPro.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd07509; HAD_PPase; 1.
DR Gene3D; 3.40.50.1000; HAD superfamily/HAD-like; 2.
DR InterPro; IPR036412; HAD-like_sf.
DR InterPro; IPR006357; HAD-SF_hydro_IIA.
DR InterPro; IPR023214; HAD_sf.
DR InterPro; IPR006355; LHPP/HDHD2.
DR NCBIfam; TIGR01460; HAD-SF-IIA; 1.
DR NCBIfam; TIGR01458; HAD-SF-IIA-hyp3; 1.
DR PANTHER; PTHR19288; 4-NITROPHENYLPHOSPHATASE-RELATED; 1.
DR PANTHER; PTHR19288:SF46; HALOACID DEHALOGENASE-LIKE HYDROLASE DOMAIN-CONTAINING PROTEIN 2; 1.
DR Pfam; PF13344; Hydrolase_6; 1.
DR Pfam; PF13242; Hydrolase_like; 1.
DR SFLD; SFLDG01139; C2.A:_Pyridoxal_Phosphate_Phos; 1.
DR SFLD; SFLDS00003; Haloacid_Dehalogenase; 1.
DR SUPFAM; SSF56784; HAD-like; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000001811}.
SQ SEQUENCE 259 AA; 28439 MW; A431F21EE964F145 CRC64;
MAARRALKAV LVDLNGTLHI EDAAVPGAQE ALKRLRGTSV MVRFVTNTTK ESKQDLLERL
RKLEFEISED EIFTSLTAAR SLVEQKQVRP MLLVDDRALP DFKGIQTNDP NAVVIGLAPE
HFHYQVLNQA FRLLLDGAPL IAIHKARYYK RKDGLALGPG PFVTALEYAT DTPATVVGKP
ETTFFLEALR STGCSPEEAV MIGDDCRDDV GGAQSAGMLG ILVKTGKYRA ADEEKISPPP
YLTCESFPKA VDHILQHLL
//
