ID G1SSE1_RABIT Unreviewed; 1052 AA.
AC G1SSE1;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 76.
DE SubName: Full=Diaphanous related formin 2 {ECO:0000313|Ensembl:ENSOCUP00000006152.3};
GN Name=DIAPH2 {ECO:0000313|Ensembl:ENSOCUP00000006152.3};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000006152.3, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000006152.3, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000006152.3,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000006152.3}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000006152.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the formin homology family. Diaphanous
CC subfamily. {ECO:0000256|ARBA:ARBA00008214}.
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DR EMBL; AAGW02046242; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02046243; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02046244; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02046245; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02046246; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02046247; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02046248; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02046249; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02046250; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02046251; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1SSE1; -.
DR SMR; G1SSE1; -.
DR STRING; 9986.ENSOCUP00000006152; -.
DR Ensembl; ENSOCUT00000007114.4; ENSOCUP00000006152.3; ENSOCUG00000007109.4.
DR eggNOG; KOG1924; Eukaryota.
DR GeneTree; ENSGT00940000157822; -.
DR HOGENOM; CLU_002356_0_0_1; -.
DR InParanoid; G1SSE1; -.
DR TreeFam; TF315383; -.
DR Proteomes; UP000001811; Chromosome X.
DR Bgee; ENSOCUG00000007109; Expressed in aorta and 15 other cell types or tissues.
DR ExpressionAtlas; G1SSE1; baseline.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl.
DR GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR GO; GO:0003779; F:actin binding; IEA:InterPro.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0030036; P:actin cytoskeleton organization; IEA:InterPro.
DR Gene3D; 1.20.58.630; -; 1.
DR Gene3D; 6.10.30.30; -; 1.
DR Gene3D; 1.10.20.40; Formin, diaphanous GTPase-binding domain; 1.
DR Gene3D; 1.20.58.2220; Formin, FH2 domain; 1.
DR Gene3D; 1.10.238.150; Formin, FH3 diaphanous domain; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR014767; DAD_dom.
DR InterPro; IPR044933; DIA_GBD_sf.
DR InterPro; IPR015425; FH2_Formin.
DR InterPro; IPR042201; FH2_Formin_sf.
DR InterPro; IPR010472; FH3_dom.
DR InterPro; IPR014768; GBD/FH3_dom.
DR InterPro; IPR010473; GTPase-bd.
DR PANTHER; PTHR45691; PROTEIN DIAPHANOUS; 1.
DR PANTHER; PTHR45691:SF3; PROTEIN DIAPHANOUS HOMOLOG 2; 1.
DR Pfam; PF06367; Drf_FH3; 1.
DR Pfam; PF06371; Drf_GBD; 1.
DR Pfam; PF02181; FH2; 1.
DR SMART; SM01139; Drf_FH3; 1.
DR SMART; SM01140; Drf_GBD; 1.
DR SMART; SM00498; FH2; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF101447; Formin homology 2 domain (FH2 domain); 1.
DR PROSITE; PS51231; DAD; 1.
DR PROSITE; PS51444; FH2; 1.
DR PROSITE; PS51232; GBD_FH3; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811}.
FT DOMAIN 54..427
FT /note="GBD/FH3"
FT /evidence="ECO:0000259|PROSITE:PS51232"
FT DOMAIN 583..983
FT /note="FH2"
FT /evidence="ECO:0000259|PROSITE:PS51444"
FT DOMAIN 1006..1036
FT /note="DAD"
FT /evidence="ECO:0000259|PROSITE:PS51231"
FT REGION 499..556
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 980..1002
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 344..371
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 510..556
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1052 AA; 120760 MW; 2EA71770A0BCB02B CRC64;
NIQIKTLADD VRDRITSFRK STVKKEKPLI QHPIDSQVAM SEFPAAQPLY DERSLNLSEK
EVLDLFEKMM EDMNLNEEKK APLRNKDFTT KREMVVQYIS ATAKSIVGSK VTGGLKNSKH
ECTLSSQEYV HELRSGISDE KLLNCLESLR VSLTSNPVSW VNNFGHEGLG LLLDVLEKLL
DKKQQENIDK KNQYKLIQCL KAFMNNKFGL QRILGDERSL LLLARAIDPK QPNMMTEIVK
ILSAICIVGE ENILDKLLGA ITTAAERNNR ERFSPIVEGL ENHEALQLQV ACMQFINALV
TSPYELDFRI HLRNEFLRSG LKTILPDLKE KENEELDIQL KVFDENKEDD LTELSHRLND
IRAEMDDMNE VYHLLYNMLK DTAAENYLLS ILQHFLLIRN DYYIRPQYYK IIEECVSQIV
LHCSGMDPDF KYRQRLDIDF THLIDSCVNK AKVEESEQKA VEFSKKFDEE FTARQEAQAE
LQKREEKIKE LETEIQQLRN QGHGLSSSSG IPGPPPPPPL PGVAPPPPPP PPLPGAIPPP
PPPPLPNIPP PPPLIGIPPP PPPFGVVPLP PGAPLDLPYG MKQKKIYKPE VSMKRINWSK
IEPKELSENC FWLKVKEDKF ENPDLFAKLA LNFATQMKVQ KNVEASEEKK SMPAKKKVKE
LRVLDAKTAQ NLSIFLGSYR MPYEDIKNII LEVNEDMLSE ALIQNLIKHL PEQKVLSELA
QLKNEYDDLC EPEQFGVVMS SVKMLQPRLN SILFKLMFEE QVNNIKPSII AVTLACEELK
KSESFNRLLE LVLLVGNYMN SGSRNAQSLG FKINFLCKIR DTKSADQKTT LLHFIAEICE
EKYRDILKFP EELEHVESAS KVSAQILKSN LAAMEKQIVH LERDIKKFPQ AENPHDKFVE
KMTIFTKSAR DQYEKLFTMH NNMVKLYENL GEYFIFDSKT VSIEEFFGDL SNFRTLFLEA
VKENNKRREM EEKTRRAKLA KEKAEQEKLE RQKKKKQLID INKEGDETGV MDNLLEALQS
GAAFRDRRKR IPRNPVVIEP YATRANSRST TK
//
