ID G1SSY0_RABIT Unreviewed; 194 AA.
AC G1SSY0;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE RecName: Full=Bcl-2-like protein 11 {ECO:0000256|PIRNR:PIRNR037827};
DE Short=Bcl2-L-11 {ECO:0000256|PIRNR:PIRNR037827};
DE AltName: Full=Bcl2-interacting mediator of cell death {ECO:0000256|PIRNR:PIRNR037827};
GN Name=BCL2L11 {ECO:0000313|Ensembl:ENSOCUP00000006383.2};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000006383.2, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000006383.2, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000006383.2,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000006383.2}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000006383.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Induces apoptosis and anoikis.
CC {ECO:0000256|PIRNR:PIRNR037827}.
CC -!- SUBUNIT: Forms heterodimers with a number of antiapoptotic Bcl-2
CC proteins including MCL1, BCL2, BCL2L1 isoform Bcl-X(L), BCL2A1/BFL-1.
CC {ECO:0000256|PIRNR:PIRNR037827}.
CC -!- SIMILARITY: Belongs to the Bcl-2 family.
CC {ECO:0000256|PIRNR:PIRNR037827}.
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DR EMBL; AAGW02007384; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1SSY0; -.
DR SMR; G1SSY0; -.
DR STRING; 9986.ENSOCUP00000006383; -.
DR PaxDb; 9986-ENSOCUP00000006383; -.
DR Ensembl; ENSOCUT00000007382.3; ENSOCUP00000006383.2; ENSOCUG00000007385.4.
DR eggNOG; ENOG502S0DF; Eukaryota.
DR GeneTree; ENSGT00390000003178; -.
DR HOGENOM; CLU_104244_0_0_1; -.
DR InParanoid; G1SSY0; -.
DR OMA; EIWIARE; -.
DR TreeFam; TF335898; -.
DR Proteomes; UP000001811; Chromosome 2.
DR Bgee; ENSOCUG00000007385; Expressed in testis and 15 other cell types or tissues.
DR GO; GO:0097136; C:Bcl-2 family protein complex; IEA:Ensembl.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-UniRule.
DR GO; GO:0008017; F:microtubule binding; IEA:Ensembl.
DR GO; GO:0060090; F:molecular adaptor activity; IEA:Ensembl.
DR GO; GO:0019901; F:protein kinase binding; IEA:Ensembl.
DR GO; GO:1902263; P:apoptotic process involved in embryonic digit morphogenesis; IEA:Ensembl.
DR GO; GO:0001782; P:B cell homeostasis; IEA:Ensembl.
DR GO; GO:0007160; P:cell-matrix adhesion; IEA:UniProtKB-UniRule.
DR GO; GO:0048066; P:developmental pigmentation; IEA:Ensembl.
DR GO; GO:0043583; P:ear development; IEA:Ensembl.
DR GO; GO:0097192; P:extrinsic apoptotic signaling pathway in absence of ligand; IEA:Ensembl.
DR GO; GO:0001701; P:in utero embryonic development; IEA:Ensembl.
DR GO; GO:0008630; P:intrinsic apoptotic signaling pathway in response to DNA damage; IEA:Ensembl.
DR GO; GO:0001822; P:kidney development; IEA:Ensembl.
DR GO; GO:0008584; P:male gonad development; IEA:Ensembl.
DR GO; GO:0030879; P:mammary gland development; IEA:Ensembl.
DR GO; GO:0002262; P:myeloid cell homeostasis; IEA:Ensembl.
DR GO; GO:0042475; P:odontogenesis of dentin-containing tooth; IEA:Ensembl.
DR GO; GO:0045787; P:positive regulation of cell cycle; IEA:Ensembl.
DR GO; GO:2000271; P:positive regulation of fibroblast apoptotic process; IEA:Ensembl.
DR GO; GO:1902110; P:positive regulation of mitochondrial membrane permeability involved in apoptotic process; IEA:Ensembl.
DR GO; GO:0043525; P:positive regulation of neuron apoptotic process; IEA:Ensembl.
DR GO; GO:0031334; P:positive regulation of protein-containing complex assembly; IEA:Ensembl.
DR GO; GO:0090200; P:positive regulation of release of cytochrome c from mitochondria; IEA:Ensembl.
DR GO; GO:0070234; P:positive regulation of T cell apoptotic process; IEA:Ensembl.
DR GO; GO:0009791; P:post-embryonic development; IEA:Ensembl.
DR GO; GO:0048070; P:regulation of developmental pigmentation; IEA:Ensembl.
DR GO; GO:0046620; P:regulation of organ growth; IEA:Ensembl.
DR GO; GO:0034976; P:response to endoplasmic reticulum stress; IEA:Ensembl.
DR GO; GO:0007283; P:spermatogenesis; IEA:Ensembl.
DR GO; GO:0048536; P:spleen development; IEA:Ensembl.
DR GO; GO:0043029; P:T cell homeostasis; IEA:Ensembl.
DR GO; GO:0070242; P:thymocyte apoptotic process; IEA:Ensembl.
DR GO; GO:0048538; P:thymus development; IEA:Ensembl.
DR GO; GO:0035148; P:tube formation; IEA:Ensembl.
DR InterPro; IPR014771; Apoptosis_Bim_N.
DR InterPro; IPR017288; Bcl-2-like_11.
DR InterPro; IPR015040; Bcl-x_interacting_BH3_dom.
DR PANTHER; PTHR12044:SF9; BCL-2-LIKE PROTEIN 11; 1.
DR PANTHER; PTHR12044; BCL2 INTERACTING MEDIATOR OF CELL DEATH; 1.
DR Pfam; PF08945; Bclx_interact; 1.
DR Pfam; PF06773; Bim_N; 1.
DR PIRSF; PIRSF037827; Bcl-2-like_p11; 1.
PE 3: Inferred from homology;
KW Apoptosis {ECO:0000256|PIRNR:PIRNR037827};
KW Membrane {ECO:0000256|PIRNR:PIRNR037827};
KW Mitochondrion {ECO:0000256|PIRNR:PIRNR037827};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811}.
FT DOMAIN 4..40
FT /note="Apoptosis Bim N-terminal"
FT /evidence="ECO:0000259|Pfam:PF06773"
FT DOMAIN 127..162
FT /note="Bcl-x interacting BH3"
FT /evidence="ECO:0000259|Pfam:PF08945"
FT REGION 1..65
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 194 AA; 21652 MW; 3FD26D487AE2EA72 CRC64;
MAKQPSDVSS ECDREGGQLQ PAERPPQLRP GAPTSLQSEP QGNPEGDRCA HGSPQGPLAP
SASPGPFATR SPLFIFVRRS SLLSRSSSGY FSFDTDRSPA PMSCDKSTQT PSPPCQAFNH
YLSAMASMRQ SQAEPADTRP ETWIAQELRR IGDEFNAYYP RRVFLNNYPA AEEQPQMVIL
RLLRYIVRLV WRMH
//
