ID G1STP4_RABIT Unreviewed; 2846 AA.
AC G1STP4;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 2.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=FRAS1 related extracellular matrix 2 {ECO:0000313|Ensembl:ENSOCUP00000006690.3};
GN Name=FREM2 {ECO:0000313|Ensembl:ENSOCUP00000006690.3};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000006690.3, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000006690.3, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke {ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000006690.3}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000006690.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the FRAS1 family.
CC {ECO:0000256|ARBA:ARBA00005529}.
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DR STRING; 9986.ENSOCUP00000006690; -.
DR PaxDb; 9986-ENSOCUP00000006690; -.
DR Ensembl; ENSOCUT00000007741.3; ENSOCUP00000006690.3; ENSOCUG00000007735.3.
DR eggNOG; KOG1306; Eukaryota.
DR eggNOG; KOG2090; Eukaryota.
DR eggNOG; KOG3597; Eukaryota.
DR GeneTree; ENSGT00940000155313; -.
DR HOGENOM; CLU_000394_0_0_1; -.
DR InParanoid; G1STP4; -.
DR OMA; ILPWELN; -.
DR TreeFam; TF316876; -.
DR Proteomes; UP000001811; Unplaced.
DR Bgee; ENSOCUG00000007735; Expressed in upper lobe of left lung and 10 other cell types or tissues.
DR GO; GO:0005604; C:basement membrane; IEA:Ensembl.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0007155; P:cell adhesion; IEA:Ensembl.
DR GO; GO:0007154; P:cell communication; IEA:InterPro.
DR GO; GO:0042733; P:embryonic digit morphogenesis; IEA:Ensembl.
DR GO; GO:0001654; P:eye development; IEA:Ensembl.
DR GO; GO:0007507; P:heart development; IEA:Ensembl.
DR GO; GO:0048839; P:inner ear development; IEA:Ensembl.
DR GO; GO:0001822; P:kidney development; IEA:Ensembl.
DR GO; GO:0002009; P:morphogenesis of an epithelium; IEA:Ensembl.
DR Gene3D; 2.60.40.2030; -; 5.
DR InterPro; IPR038081; CalX-like_sf.
DR InterPro; IPR003644; Calx_beta.
DR InterPro; IPR039005; CSPG_rpt.
DR PANTHER; PTHR45739:SF4; FRAS1-RELATED EXTRACELLULAR MATRIX PROTEIN 2; 1.
DR PANTHER; PTHR45739; MATRIX PROTEIN, PUTATIVE-RELATED; 1.
DR Pfam; PF16184; Cadherin_3; 12.
DR Pfam; PF03160; Calx-beta; 5.
DR SMART; SM00237; Calx_beta; 5.
DR SUPFAM; SSF141072; CalX-like; 5.
DR PROSITE; PS51854; CSPG; 12.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 2788..2812
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 1..89
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 114..212
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 235..349
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 374..481
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 502..593
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 619..711
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 740..842
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 863..956
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 977..1073
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1094..1186
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1206..1295
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1329..1426
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT DOMAIN 1433..1532
FT /note="Calx-beta"
FT /evidence="ECO:0000259|SMART:SM00237"
FT DOMAIN 1545..1656
FT /note="Calx-beta"
FT /evidence="ECO:0000259|SMART:SM00237"
FT DOMAIN 1673..1777
FT /note="Calx-beta"
FT /evidence="ECO:0000259|SMART:SM00237"
FT DOMAIN 1792..1894
FT /note="Calx-beta"
FT /evidence="ECO:0000259|SMART:SM00237"
FT DOMAIN 1912..2016
FT /note="Calx-beta"
FT /evidence="ECO:0000259|SMART:SM00237"
FT REGION 2714..2734
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2815..2846
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2714..2731
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2831..2846
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2846 AA; 316361 MW; 0DC927B21F0578C7 CRC64;
MMMMEVDQFV LTALTPDMLA AEDAESAPDL LIFNLTSPFQ PGQGYLVSTD DRSLPLSSFT
QRDLRLLKIA YQPPSEDSDQ ERLFELELEV VDPEGAASDP FAFMVVVKPM NTLAPVVTRN
TGLILYEGQA RPLTGPADGG SQNLVISDED DLEAVQLEVV AGLRHGHLVI LGASGSIAPK
TFSVAELAAG QVVYQHDDRD GSLSDNLVLR MMDGGGRHQV QFLFPITLVP VDDQPPVLNA
NTGLTLAEGE TVPILPLQLS ATDMDSDDAV LLFVLESPST TGHLLLRQTH PPHEEEELTR
GQWKKQGAFY ERPVTEWRQQ DITEGRLFYR HSGPHSPGPV MDQLTFRVQD NNDPPNQSGL
QKFVVRIHPV DRLPPELGSG CPLRMVVQES QLTPLRKKWL RYTDLDTDDR ELRYTVTQPP
VDTDENHSPA PLGTLVLSDN PSVMVTHFTQ AQINHHKIAY RPPSEELGVA ARVAQFRFQV
EDKAGNVAPG TFTFYLQPVD NQPPEILNTG FTIQEKGHHI LSETELHVHD VDTDMAHISF
TLTQAPKHGQ VQVSGQILPV GGIFHLEDIK QGRISYAHNG DDSLTDSCSL EVSDRHHVVP
ITLRVNIRPV DDEVPMLNLP AGTLESYLDV LENGATEITA SVIKGTNKGT DDLMLTFLLE
DPPLYGEILV NGAPAEQFTQ QDILEGSVVY AHTSGEIGLL PKADSFNLSL SDTSQEWRIS
GNTIQGVTVW VTILPVDSQP PEISVGEQFM VLEGDKSVIT STHISAQDID SLNDDILCTI
IIQPTSGYVE NISPAPGSEK SRAGIAVSAF TLKDLRQGHI NYIQSVHQGV EPVEDRFIFR
CSDGINFSER QFFPIVIIPT NDEQPEMFMR EFMVMEGMSL VIDTPILNAA DADIPPDDLT
FTITRFPTHG HIMNQLINGT VLVESFTLDQ IVESSSIIYE HDDSETQEDS FVIKLTDGKH
SVEKMVLIMV IPVDDETPRM TINNGLEIEI GETKIISNKI LMATDLDSED KYLVYIIRYG
PRHGLLQRRR PMGALENITL GMNFTQEEVD RNLIQYVHTG QEGIRDLIKF DVTDGINALI
DRYFYVSIGS IDIVFPDVIS KGVSLKEGGK VTLTTDLLST SDLNSPDEYL VFTITRAPMR
GHLECTDQPG VSVMSFTQLQ LAGNKIYYIH TADDEVKMDS FEFQVTDGHN PVFRTFRISI
SDVDNKKPVV TIHNLVVSEN ENKLITPFEL TVEDRDTPDR LLKFTVTQVP VHGHLLFNNT
RPVMVFTKQD LNENLISYKH DGTESSEDSF SFTVTDGTHA DFYVFPDTVF ETRRPQVMKI
QVLAVDNSVP QIAVNKGAST LRTLATGHLG FMITNKVLRV VDRDSQHFSL RFIVTEAPQH
GYLLNLGKGN HSVTQFTQAD IDDMKICYVL RKGANTTSDM FHFAVEDGGG NKLTNQHFRL
NWAWISFEKE YYLINEDSKF LDVVLKRRGY LGETSFISIG TRDGTAEKDK DFKGKAQKQV
QFNPGQTRAT WRVRIVGDGE HEQSETFQVV LSEPVLAALE FPAATTVEII DPGDESTVFI
PHPEYSVEEN VGELFIPIRR TGDVSRELMV ICYTQQGTAT GTVPTSVLSY SDYISRPEDH
TSIVRFDRDE QEKMCRIVVI DDSLYEEEET FHVLLSMPMG GRLGSEFPGA QITIVPDKDD
EPVFYFGDVK YSVDESAGYV EVQVWRTGTD LSRSSSVTVR SRKTDPPSAE AGTDYVGISR
HLDFAPGANM QTVRVIILDD LGQPVLEGIE KFELVLRMPM NAALGEPSKA TVTINDSVSD
LPKMQFKERM YTGSENDGQI VAVIHRSGDI QYQSSVRCYT RQGSAQVMMD FEERPNTDIS
VITFLPGETE KPCILELMDD TLYEEVEELR LVLGTPQSSS PFGAAVGEQN ETLIRILDDA
DKTIIKFGET KFIITEPKEQ GESVIIKIPV IRQGDTSKVS IVRVHTKDGS ATSGEDYHPV
SEEIEFKEGE TQHIVEIEVI FDGVREMREA FTVHLKPDEN MIAETQMTKA IVYIEEMNSM
ADVTFPSVPQ VMSLLMYDDT SRAKEGTGPV SGYPVICITA CNPKYSDYDK TGSICASENI
NDTLTRYRWL ISAPASPDGV TSPMREVDFD TFFTSSKMIT LDSIYFQPGS RVQCAARAVN
TDGNEGLELM SPIVTIGREE GLCQPRVPGV VGAEPFSAKL RYTGPEDPDF ANLIKLTVTM
PHIDGMLPVI STRELSNFEL TLSPDGTRVG NHRCSNLLDY TEVKTHHGFL TDATKNPEVI
GETFPYQYSS SIRGSSTLRF YRNLNLEACL WEFVSYYDMS ELLTDCGGSI GTDGQVLNLV
QSYVTLRVPL YVSYVFHSPV GVGGWQHFDL KSELRLTFVY DTAILWNDGI GSPPEAELQG
SLYPTSMRIG EEGRLAVNFK TEAQFHGLFV LSHPASFTSS VVMSADHPGL TFSLRLIRSE
PTYNQPIQQW SFVSDFAVRD YSGTYTVKLV PCTTPSNQEY HLPVLCNPRE PVTFDLDIRF
QQVSDPVAAE FSLNTQMYLL SKKSLWLSDG SMGFGQESDV AFAEGDIIYG RVMVDPVQNL
GDSFYCSIEK VFLCTGADGY VPKYSPVNAE YGCLADSPSL LYRFKIVDKA QPETQATSFG
NVLFNAKLAA DDPEAILLVN QPGSDGFKVD STPLFQVALG REWYIHTIYT VRSKDNVNRG
IGKRSVENQY HSLVHQGKPQ ATTTSRRKRE IQSTPPLARE IGAENNRGTN IQHIALDRTH
RRQTPHGRVP PDGSLPWELN SPGSEVSLIT VVGGIAVGLL TICLIVIAAV MCKSKKNSKE
KNDPKGSSSR EPMVLPQSHH SDSSEV
//
