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Database: UniProt
Entry: G1STX1_RABIT
LinkDB: G1STX1_RABIT
Original site: G1STX1_RABIT 
ID   G1STX1_RABIT            Unreviewed;       794 AA.
AC   G1STX1;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   24-JAN-2024, entry version 70.
DE   SubName: Full=Cadherin 12 {ECO:0000313|Ensembl:ENSOCUP00000006773.2};
GN   Name=CDH12 {ECO:0000313|Ensembl:ENSOCUP00000006773.2};
OS   Oryctolagus cuniculus (Rabbit).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX   NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000006773.2, ECO:0000313|Proteomes:UP000001811};
RN   [1] {ECO:0000313|Ensembl:ENSOCUP00000006773.2, ECO:0000313|Proteomes:UP000001811}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000006773.2,
RC   ECO:0000313|Proteomes:UP000001811};
RX   PubMed=21993624; DOI=10.1038/nature10530;
RA   Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA   Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA   Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA   Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA   Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA   Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA   Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA   Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA   Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA   Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA   Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA   Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA   Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA   Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA   Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT   "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL   Nature 478:476-482(2011).
RN   [2] {ECO:0000313|Ensembl:ENSOCUP00000006773.2}
RP   IDENTIFICATION.
RC   STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000006773.2};
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- FUNCTION: Cadherins are calcium-dependent cell adhesion proteins.
CC       {ECO:0000256|RuleBase:RU004357}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251,
CC       ECO:0000256|RuleBase:RU003318}; Single-pass type I membrane protein
CC       {ECO:0000256|ARBA:ARBA00004251, ECO:0000256|RuleBase:RU003318}.
CC       Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC       protein {ECO:0000256|ARBA:ARBA00004479}.
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DR   EMBL; AAGW02030117; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAGW02030118; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAGW02030119; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAGW02030120; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAGW02030121; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAGW02030122; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAGW02030123; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAGW02030124; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAGW02030125; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAGW02030126; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_017200150.1; XM_017344661.1.
DR   AlphaFoldDB; G1STX1; -.
DR   SMR; G1STX1; -.
DR   STRING; 9986.ENSOCUP00000006773; -.
DR   PaxDb; 9986-ENSOCUP00000006773; -.
DR   Ensembl; ENSOCUT00000007835.4; ENSOCUP00000006773.2; ENSOCUG00000007832.4.
DR   GeneID; 100340496; -.
DR   KEGG; ocu:100340496; -.
DR   CTD; 1010; -.
DR   eggNOG; KOG3594; Eukaryota.
DR   GeneTree; ENSGT00940000154187; -.
DR   HOGENOM; CLU_005284_3_1_1; -.
DR   InParanoid; G1STX1; -.
DR   OMA; FTRHRPP; -.
DR   OrthoDB; 3667774at2759; -.
DR   TreeFam; TF329887; -.
DR   Proteomes; UP000001811; Chromosome 11.
DR   Bgee; ENSOCUG00000007832; Expressed in frontal cortex and 3 other cell types or tissues.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR   CDD; cd11304; Cadherin_repeat; 5.
DR   Gene3D; 2.60.40.60; Cadherins; 5.
DR   Gene3D; 4.10.900.10; TCF3-CBD (Catenin binding domain); 1.
DR   InterPro; IPR039808; Cadherin.
DR   InterPro; IPR002126; Cadherin-like_dom.
DR   InterPro; IPR015919; Cadherin-like_sf.
DR   InterPro; IPR020894; Cadherin_CS.
DR   InterPro; IPR000233; Cadherin_Y-type_LIR.
DR   InterPro; IPR027397; Catenin-bd_sf.
DR   PANTHER; PTHR24027:SF96; CADHERIN-12; 1.
DR   PANTHER; PTHR24027; CADHERIN-23; 1.
DR   Pfam; PF01049; CADH_Y-type_LIR; 1.
DR   Pfam; PF00028; Cadherin; 5.
DR   PRINTS; PR00205; CADHERIN.
DR   SMART; SM00112; CA; 5.
DR   SUPFAM; SSF49313; Cadherin-like; 5.
DR   PROSITE; PS00232; CADHERIN_1; 1.
DR   PROSITE; PS50268; CADHERIN_2; 5.
PE   4: Predicted;
KW   Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW   ProRule:PRU00043};
KW   Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW   ECO:0000256|RuleBase:RU003318};
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU003318};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           26..794
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5003423007"
FT   TRANSMEM        606..637
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          80..160
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          161..269
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          270..384
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          385..489
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          489..607
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
SQ   SEQUENCE   794 AA;  88386 MW;  086AA1D4C67615B6 CRC64;
     MLTRNCLSLL LWVLFDGGLL TPLQPQPRQT LTTEPRENVL RLPGRRLHFQ RVKRGWVWNQ
     FFVLEEYMGA EPQYVGKLHS DLDKGEGTVK YTLSGDGAGT VFTIDETTGD IHAIRSLDRE
     EKPFYTLRAQ AVDIETRKPL EPESEFIIKV QDINDNEPRF LDGPYVASVP EMSPVGAYVL
     QVKATDADDP TYGNSARVVY SILQGQPYFS IDPKTGVIRT ALPNMDREVK EQYQVLIQAK
     DMGGQLGGLA GTTIVNITLT DVNDNPPRFP KSIFHLKVPE SSPVGSAVGR IRAVDPDFGQ
     NAEIEYNIVP GDGGNLFDII TDEETQEGVI KLKKPLDFET KKAYTFKVEA SNLHLDHRFH
     SAGPFKDTAT VKISVLDVDE PPVFSKPLYT MEVYEDTPVG TIIGAVTAQD LDVGSSAVRY
     FIDWKSDGDS YFTIDGTEGT IATNELLDRE STAQYNFSII ASKVSNPLLT SKVNIVINVL
     DVNEFPPEIS VPYETAVCEN AKPGQIIQIV SAADRDLSPA GQQFSFRLSP EAAIKPNFTV
     RDFRNNTAGI ETRRNGYSRR QQELYFLPVV IEDSSYPIQS STNTMTIRVC RCDSDGTILS
     CNVEAIFLPV GLSTGALIAI LLCIVILLAI VVLYVALRRQ KKKDTLMTSK EDIRDNVIHY
     DDEGGGEEDT QAFDIGALRN PKVIEENKIR RDIKPDTFCL PRQRPPVEDN TDIRDFINQR
     LQENDVDPAA PPYDSLATYA YEGSGSVAES LSSIDSLTTE ADQDYDYLTG WGPRFKVLAD
     MFGEEESYNP DKVT
//
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