ID G1SU64_RABIT Unreviewed; 1648 AA.
AC G1SU64;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=DENN domain containing 4A {ECO:0000313|Ensembl:ENSOCUP00000006882.3};
GN Name=DENND4A {ECO:0000313|Ensembl:ENSOCUP00000006882.3};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000006882.3, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000006882.3, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000006882.3,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000006882.3}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000006882.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAGW02025145; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02025146; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSOCUT00000007964.3; ENSOCUP00000006882.3; ENSOCUG00000007953.4.
DR eggNOG; KOG2127; Eukaryota.
DR GeneTree; ENSGT00940000155836; -.
DR HOGENOM; CLU_003074_0_0_1; -.
DR TreeFam; TF313237; -.
DR Proteomes; UP000001811; Chromosome 17.
DR Bgee; ENSOCUG00000007953; Expressed in blood and 15 other cell types or tissues.
DR ExpressionAtlas; G1SU64; baseline.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR Gene3D; 2.100.10.50; -; 1.
DR Gene3D; 3.40.50.11500; -; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR001194; cDENN_dom.
DR InterPro; IPR005112; dDENN_dom.
DR InterPro; IPR043153; DENN_C.
DR InterPro; IPR023341; MABP.
DR InterPro; IPR002885; Pentatricopeptide_rpt.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR037516; Tripartite_DENN.
DR InterPro; IPR005113; uDENN_dom.
DR NCBIfam; TIGR00756; PPR; 1.
DR PANTHER; PTHR12296:SF16; C-MYC PROMOTER-BINDING PROTEIN; 1.
DR PANTHER; PTHR12296; DENN DOMAIN-CONTAINING PROTEIN 4; 1.
DR Pfam; PF03455; dDENN; 1.
DR Pfam; PF02141; DENN; 1.
DR Pfam; PF03456; uDENN; 1.
DR SMART; SM00801; dDENN; 1.
DR SMART; SM00799; DENN; 1.
DR SMART; SM00800; uDENN; 1.
DR PROSITE; PS50211; DENN; 1.
DR PROSITE; PS51498; MABP; 1.
DR PROSITE; PS51375; PPR; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811}.
FT DOMAIN 42..200
FT /note="MABP"
FT /evidence="ECO:0000259|PROSITE:PS51498"
FT DOMAIN 192..629
FT /note="UDENN"
FT /evidence="ECO:0000259|PROSITE:PS50211"
FT REPEAT 782..816
FT /note="PPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00708"
FT REGION 717..736
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 965..1001
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1067..1092
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1125..1172
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 975..993
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1156..1170
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1648 AA; 185881 MW; D167BFABBB851FB8 CRC64;
MIEDKGPRVA DYFVVAGLTD VSKPLEEEIH FNDACHKVAK PKEPITDVSV IIKSLGEEVP
QDYMCIDVTP TGLSADLNNG SLVGPQIYLC YRRGRDKPPL TDLGVLYDWK ERLKQGCEII
QNTPYGRPAN ISGSTSSQRI YITYRRASEN MPQNALAVTD ICIIIPSKGE SPPHTFCRVD
KNLNNSMWGS AVYLCYKKSV AKTNTVSYKA GLICRYPQED YESFSLPESV PLFCLPMGAT
IECWPPNSKY PLPVFSTFVL TGASAEKVYG AAIQFYEPYP EENLTEKQRL LLGLASLADG
KSDSSKTIHT NKCICLLSHW PFFDAFRKFL TFLYRYSISG PHVLPIEKHI SHFMHKVPFP
SPQRPRILVQ LSPHDNLILS QPVSSPLPLS GGKFSTLLQN LGPENAVTLL VFAVTEHKIL
IHSLRPSVLT SVTEALVSMI FPFHWPCPYV PLCPLALADV LSAPCPFIVG IDSRYFDLYD
PPPDVSCVDL DTNTISQNGD KKNVAWKILP KKPCKNLMNT LNNLHQQLAK SMNDYDFNSG
KRLHMIDLEI QEAFLFFMAS ILKGYRSYLR PITQAPSETA TDATSLFALQ AFLRSRDRSH
QKFYNMMTKT QMFIRFIEEC SFVSDKDASL AFFDDCVDKN LAPQRGLEPR VPVDMDKSGE
VRLIELDESF KSEHTVFVTP PEIPCLPNGE EPPLQYSYSG FPVLRNNLFE RPEGFLQTQK
SKLPSKSSSP SSPSPMFRRT KQGLGFICLP AYVKVCHSKV RALKTAYDVL KKMQSKKMDP
PDEVCYRILM QLCGQYDQPV LAVRVLFEMH KAGIDPNAIT YGYYNKAVLE STWPSRSRSG
YFLWTKVRNV VLGVAQFKRA LKKHAHLSQT TLSESTRELL LISSLEDTNE TGNIESRCFR
KRHKSDNDSN LQQQMAWGNR NRNLSGGVLM GFMLNRINQK ANPGDIVEKL GADAKILSNV
ISRSTRPNSL DIGKPPLRSK RDSLEKESSD DDTPFDGSNC LADKVDSPVI FDLEDLDNET
DGSKVGYVAT QNSKRIQRMN SNFSAKPSEK TDVATGFDPL SLLVAETEQQ QKEEEEEDED
DSKSISTPSA RRDLAEEIVM YMNNMSSPLT SRTPSIDLQR ACDDKLNNKK SPTLAKACRR
SSLPPNSPRP VRLTKSKSYT KSEERPRDRL WSSPAFSPTC PFREESQDTL THSSPSFNLD
TLLVPKLDVL RNSMFTAGKG VAEKASKWYS RFTMYTSSSK VSVSYFDFDN TCHHYQKFLT
CEDFALPGKS EVTSSFNMSN TNIFQNYAME VLISSCSRCR TCDCLVHDEE IMAGWTADDS
NLNTTCPFCG NLFLPFLNIE IRDLRRPGSK SKLQEDSCAR SIQIPANRSK TTMSKCPVFP
MARSISTYGP LDKEDTGGQK LIPTGSLPAT LQGATDSLGL EWHLPSPDPV TVPYLSPLVV
WKELESLLEN EGDHAIAVAD FVDHHPIVFW NLVWYFRRLD LPSNLPGLIL SSEHCNKYSK
IPRHCMSEDS KHVLIQMLWD NMKLHQDPGQ PLYILWNAHS KYRQGMVTSS LIVKSIKMND
VYGPMSQILE TLSKCPHFKR QRSLYREILF LSLVALGREN IDIDAFDKEY KMAYDRLTPS
QVRSTHNCDR PPSTGVMECR KTFGEPYL
//
