ID G1SU66_RABIT Unreviewed; 279 AA.
AC G1SU66;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=Four and a half LIM domains 2 {ECO:0000313|Ensembl:ENSOCUP00000006884.3};
GN Name=FHL2 {ECO:0000313|Ensembl:ENSOCUP00000006884.3};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000006884.3, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000006884.3, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000006884.3,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000006884.3}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000006884.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAGW02007608; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02007609; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_002709754.1; XM_002709708.3.
DR RefSeq; XP_008251296.1; XM_008253074.2.
DR RefSeq; XP_017194818.1; XM_017339329.1.
DR AlphaFoldDB; G1SU66; -.
DR PaxDb; 9986-ENSOCUP00000006884; -.
DR Ensembl; ENSOCUT00000007966.3; ENSOCUP00000006884.3; ENSOCUG00000007967.3.
DR GeneID; 100337959; -.
DR KEGG; ocu:100337959; -.
DR CTD; 2274; -.
DR eggNOG; KOG1704; Eukaryota.
DR GeneTree; ENSGT00950000183028; -.
DR HOGENOM; CLU_001357_2_0_1; -.
DR OrthoDB; 370973at2759; -.
DR TreeFam; TF321684; -.
DR Proteomes; UP000001811; Chromosome 2.
DR Bgee; ENSOCUG00000007967; Expressed in heart and 19 other cell types or tissues.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd09422; LIM1_FHL2; 1.
DR CDD; cd09426; LIM2_FHL2; 1.
DR CDD; cd09433; LIM4_FHL2; 1.
DR Gene3D; 2.10.110.10; Cysteine Rich Protein; 4.
DR InterPro; IPR001781; Znf_LIM.
DR PANTHER; PTHR24205; FOUR AND A HALF LIM DOMAINS PROTEIN; 1.
DR PANTHER; PTHR24205:SF3; FOUR AND A HALF LIM DOMAINS PROTEIN 2; 1.
DR Pfam; PF00412; LIM; 4.
DR SMART; SM00132; LIM; 4.
DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 5.
DR PROSITE; PS00478; LIM_DOMAIN_1; 3.
DR PROSITE; PS50023; LIM_DOMAIN_2; 3.
PE 4: Predicted;
KW LIM domain {ECO:0000256|ARBA:ARBA00023038, ECO:0000256|PROSITE-
KW ProRule:PRU00125}; Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00125};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00125}.
FT DOMAIN 38..98
FT /note="LIM zinc-binding"
FT /evidence="ECO:0000259|PROSITE:PS50023"
FT DOMAIN 99..160
FT /note="LIM zinc-binding"
FT /evidence="ECO:0000259|PROSITE:PS50023"
FT DOMAIN 219..279
FT /note="LIM zinc-binding"
FT /evidence="ECO:0000259|PROSITE:PS50023"
SQ SEQUENCE 279 AA; 32147 MW; BA678C033D4B4B97 CRC64;
MTERFDCHHC NESLFGKKYI LREESPYCVP CFEALYANTC EECGKPIGCD CKDLSYKDRH
WHEACFHCSQ CRSSLVDKPF AAKEEQLLCT DCYSNEYSSK CQECKRTIMP GTRKMEYKGS
SWHETCFSCH RCQQPIGTKS FIPKDNQNFC VPCYEKQYAL QCVQCKKPIT TGGVTYREQP
WHRECFVCTA CKKQLSGQRF TARDDFAYCL SCFCDLYAKK CAGCTNPISG IGGTKYISFE
ERQWHNDCFN CKKCSLSLVG RGFLTERDDI LCPDCGKDI
//
