ID G1SU74_RABIT Unreviewed; 883 AA.
AC G1SU74;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=Zinc finger protein 777 {ECO:0000313|Ensembl:ENSOCUP00000006892.4};
GN Name=ZNF777 {ECO:0000313|Ensembl:ENSOCUP00000006892.4};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000006892.4, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000006892.4, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000006892.4,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000006892.4}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000006892.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAGW02057903; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02057904; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02057905; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02057906; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02057907; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1SU74; -.
DR SMR; G1SU74; -.
DR STRING; 9986.ENSOCUP00000006892; -.
DR PaxDb; 9986-ENSOCUP00000006892; -.
DR Ensembl; ENSOCUT00000007975.4; ENSOCUP00000006892.4; ENSOCUG00000007975.4.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000155153; -.
DR HOGENOM; CLU_002678_76_2_1; -.
DR InParanoid; G1SU74; -.
DR TreeFam; TF337777; -.
DR Proteomes; UP000001811; Chromosome 7.
DR Bgee; ENSOCUG00000007975; Expressed in skeletal muscle tissue and 18 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0008285; P:negative regulation of cell population proliferation; IEA:Ensembl.
DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; IEA:Ensembl.
DR GO; GO:0051291; P:protein heterooligomerization; IEA:Ensembl.
DR CDD; cd07765; KRAB_A-box; 1.
DR Gene3D; 6.10.140.140; -; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 9.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR23232; KRAB DOMAIN C2H2 ZINC FINGER; 1.
DR PANTHER; PTHR23232:SF145; ZINC FINGER PROTEIN 746-RELATED; 1.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 9.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 9.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 5.
DR SUPFAM; SSF109640; KRAB domain (Kruppel-associated box); 1.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 9.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 9.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00042}.
FT DOMAIN 285..356
FT /note="KRAB"
FT /evidence="ECO:0000259|PROSITE:PS50805"
FT DOMAIN 546..573
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 574..596
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 636..663
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 664..691
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 694..721
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 722..749
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 750..777
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 778..805
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 806..833
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT REGION 1..71
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 87..140
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 339..366
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 400..431
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 487..545
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 599..634
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 48..65
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 87..103
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 413..430
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 883 AA; 99183 MW; 41EB184DA9F23E52 CRC64;
MENQRSSPLS FPNVPQEEPL RQAPAGLPRE TLFQSRVLPP KETPSLSPAV PRQGSLPQTA
GVPKQETSGR MPRVLQKGPA LLCPATSEQE THLQGTLASQ EETQYPPPAA ADQDVSLLSH
PTHHQEAPLP SPEVPEKDRL TLSPTVPETD LDPLLQSPVS QKDTPFQISS SAQKEQPLPT
AEITRLAVWA AVQAVERKLE AQAMRLLTLE GRTGTNEKKI ADCEKTAVEF ANHLESKWVV
LGTLLQEYGL LQRRLENMEN LLKNRNFWIL RLPPGSNGEV PKVPVTFDDV AVHFSEQEWG
NLSEWQKELY KNVMRGNYES LVSMDYAISK PDLMSQMERG ERPTMQEQED SEEGETPTDP
STAHDGIVIK IEVQTNDEGS ESLETPEPLM GQVEEHGFQD SELGDTCGEQ PDLDMQEQEH
ALEESPDGSG EFSELKQMLV QQRNCTEGIV IKTEEQDEEE EDEEEDELPQ HLQSLGQLSG
RYDASIYQTP LPGEMSPEGE ESPPPLQLGN PAVKRLAPSV RGERHLGEGR GSASQQQRNR
RGERPFTCME CGKSFRLKIN LIIHQRNHIK EGPYECAECE ISFRHKQQLT LHQRIHRVRG
GYGSPERGPA FNPKHALKPR PKSPSSGSGG GGPKPYKCPE CDSSFSHKSS LTKHQITHTG
ERPYTCPECK KSFRLHISLV IHQRVHAGKH EVSFICSLCG KSFSRPSHLL RHQRTHTGER
PFKCPECEKS FSEKSKLTNH CRVHSRERPH ACPECGKSFI RKHHLLEHRR IHTGERPYHC
AECGKRFTQK HHLLEHQRAH TGERPYPCTH CAKCFRYKQS LKYHLRTHTG APEPFCCEPP
SPFIPSPQDL GVVKPGRLLP RFPRAHGGWG RARGGPGEPL SGC
//
