ID G1SUC5_RABIT Unreviewed; 975 AA.
AC G1SUC5;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 58.
DE SubName: Full=Family with sequence similarity 13 member A {ECO:0000313|Ensembl:ENSOCUP00000006951.4};
GN Name=FAM13A {ECO:0000313|Ensembl:ENSOCUP00000006951.4};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000006951.4, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000006951.4, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000006951.4,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000006951.4}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000006951.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the FAM13 family.
CC {ECO:0000256|ARBA:ARBA00007549}.
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DR EMBL; AAGW02022554; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02022555; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02022556; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02022557; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02022558; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02022559; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02022560; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02022561; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02022562; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02022563; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1SUC5; -.
DR PaxDb; 9986-ENSOCUP00000006951; -.
DR Ensembl; ENSOCUT00000008042.4; ENSOCUP00000006951.4; ENSOCUG00000008037.4.
DR eggNOG; KOG4270; Eukaryota.
DR GeneTree; ENSGT00950000183033; -.
DR HOGENOM; CLU_012606_1_0_1; -.
DR TreeFam; TF328895; -.
DR Proteomes; UP000001811; Chromosome 15.
DR Bgee; ENSOCUG00000008037; Expressed in ovary and 15 other cell types or tissues.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR039102; FAM13.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR15904; FAM13; 1.
DR PANTHER; PTHR15904:SF18; PROTEIN FAM13A; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000001811}.
FT DOMAIN 43..231
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 330..368
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 385..444
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 456..604
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 634..668
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 734..764
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 936..975
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 338..352
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 354..368
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 385..411
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 412..434
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 488..503
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 504..529
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 531..566
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 637..657
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 739..754
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 960..975
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 975 AA; 109363 MW; D72F2CF2980AF824 CRC64;
MGAGALAICQ SKAAVRLRED MKKIVAVPAS AARDPAHQQV FGVSLLELRQ RGLAEHGVPA
VVWSLVEYLT QHGLTQEGLF RVNGNVKAVQ RLRLRFESGA PVELGRDGDV CVAASLLKLF
LRELPEGVIT SAVQLRLLRL FQGGRSETQE SSLRDLLKEL PEPHYCLLKY LCHFLRQVAQ
HHAQNRMNVH NLATVFGPNC FHVSPGLEGM KEQDLCNKIM AKILENYSTL FEVECADHED
QKCENLTKLL IVKEHHICQQ WTGSGKAISL EEASHKNSLP IVLTKDLEKD VPKPSPQTKI
PKSRSEGCIQ GHRVPQALLS DGASQVGLWL SRRKPSMDNV TSTEDARGAK RRSSAHVSQV
SSVSSTGELL ERTIRSAVEQ HLFDVNSSGG QSSEDSESGP SSASSTATSA RQRRRQSKEQ
DEARRGREKE LINKENIPSG FSNLDDCILN TQEVEKLHES TSGSAGERSK PRLQKPSAKL
PELNENQDGL VDTESLSSTR SHVRTTPDDV EPMSDESKEK ERDGGHTQHF ESPTMKIQEP
ASLPDTKQQR SQDPGEDQQE SFGSEVPQLD LTALCDDKSW EEPIPTLSSW QRESVDSDEA
RLSPQAGRLI RQLLDEDSDP MLSPRFYAYG QSRQYLDDTE VPPSPPNSHS FMRRRSSSLG
SCDDEQEDLT PAQLTRRIQS LKKKIRKFED RFEEERKYRP SHSDKAANPE VLKWTNDLAK
FRKQLKESKL KISEEALAPR TRQRSNTLPK SFGSQLERED SKKPELVEKA VKPSVEVTLE
SIQRKLQEKR AEAGRPEDIK DMTKEQIANE KVALQKALLH YESIHGRPVT KSERQVMKPL
YDRYRLVKQI LSRASAVPII GSPSSRRRSP SLQPIIEGET ASFFKEIKEE EAGSEEDHNT
TPDFTVTLMT DFSARCFLDQ FEDDADGFIS PMDDKIPYKG SQDTGFSNLH AASIPELLDT
SGNERREEED SKESP
//