ID G1SUE6_RABIT Unreviewed; 308 AA.
AC G1SUE6;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=Syntaxin 18 {ECO:0000313|Ensembl:ENSOCUP00000006976.4};
GN Name=STX18 {ECO:0000313|Ensembl:ENSOCUP00000006976.4};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000006976.4, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000006976.4, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000006976.4,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000006976.4}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000006976.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004211}; Single-
CC pass type IV membrane protein {ECO:0000256|ARBA:ARBA00004211}.
CC -!- SIMILARITY: Belongs to the syntaxin family.
CC {ECO:0000256|ARBA:ARBA00009063}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AAGW02009855; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02009856; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02009857; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02009858; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02009859; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1SUE6; -.
DR PaxDb; 9986-ENSOCUP00000006976; -.
DR Ensembl; ENSOCUT00000008071.4; ENSOCUP00000006976.4; ENSOCUG00000008072.4.
DR eggNOG; KOG3894; Eukaryota.
DR GeneTree; ENSGT00390000014853; -.
DR HOGENOM; CLU_071402_1_0_1; -.
DR TreeFam; TF105868; -.
DR Proteomes; UP000001811; Chromosome 2.
DR Bgee; ENSOCUG00000008072; Expressed in autopod skin and 18 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR InterPro; IPR019529; Syntaxin-18_N.
DR PANTHER; PTHR15959; SYNTAXIN-18; 1.
DR PANTHER; PTHR15959:SF0; SYNTAXIN-18; 1.
DR Pfam; PF10496; Syntaxin-18_N; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 285..306
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 4..96
FT /note="SNARE-complex protein Syntaxin-18 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF10496"
FT REGION 171..206
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 308 AA; 35485 MW; 3E91C880840D6D17 CRC64;
MAVDITLLFR ASVKTVKTRN KALGVAVGGG VEGSRDELFR RTPRPKGDFS NRAREVISHI
GKLRDFLLEH RKDYINAYSH VLSDCGRMTD TERDQIDQDA QIFMRTCSEA IQQLRTDAHR
EVHSQQVKEH RTAVLDFIED YLKRVCKLYS EQRAIRVKRV VDKKRLSKLE PEPNVKTREA
ISSEKASPNP SKDSGEKPAS EEFPEKIVSE APTDLSTWGD GRGEDELSPE EIQMFEQENQ
RLIGEMNSLF DEVRQIEGKV VEISRLQEIF TEKVLQQAIK NNAGFRVWIL FFLVMCSFSL
LFLDWYDS
//
