ID G1SVA2_RABIT Unreviewed; 638 AA.
AC G1SVA2;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE RecName: Full=Growth hormone receptor {ECO:0000256|ARBA:ARBA00017448};
DE AltName: Full=Somatotropin receptor {ECO:0000256|ARBA:ARBA00031294};
GN Name=GHR {ECO:0000313|Ensembl:ENSOCUP00000007343.2};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000007343.2, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000007343.2, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000007343.2,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000007343.2}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000007343.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Receptor for pituitary gland growth hormone involved in
CC regulating postnatal body growth. On ligand binding, couples to, and
CC activates the JAK2/STAT5 pathway. {ECO:0000256|ARBA:ARBA00043857}.
CC -!- FUNCTION: The soluble form (GHBP) acts as a reservoir of growth hormone
CC in plasma and may be a modulator/inhibitor of GH signaling.
CC {ECO:0000256|ARBA:ARBA00003894}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the type I cytokine receptor family. Type 1
CC subfamily. {ECO:0000256|ARBA:ARBA00007885}.
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DR EMBL; AAGW02030572; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02030573; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02030574; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02030575; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02030576; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02030577; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02030578; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02030579; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02030580; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02030581; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_008260268.1; XM_008262046.2.
DR RefSeq; XP_008260269.1; XM_008262047.2.
DR RefSeq; XP_008260270.1; XM_008262048.2.
DR RefSeq; XP_008260271.1; XM_008262049.2.
DR RefSeq; XP_008260272.1; XM_008262050.2.
DR RefSeq; XP_017199997.1; XM_017344508.1.
DR RefSeq; XP_017199999.1; XM_017344510.1.
DR AlphaFoldDB; G1SVA2; -.
DR Ensembl; ENSOCUT00000008495.2; ENSOCUP00000007343.2; ENSOCUG00000008496.3.
DR GeneID; 100009325; -.
DR CTD; 2690; -.
DR GeneTree; ENSGT00940000159987; -.
DR HOGENOM; CLU_022322_0_0_1; -.
DR OMA; YKPQLYN; -.
DR OrthoDB; 5317462at2759; -.
DR TreeFam; TF330851; -.
DR Proteomes; UP000001811; Chromosome 11.
DR Bgee; ENSOCUG00000008496; Expressed in liver and 17 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004896; F:cytokine receptor activity; IEA:InterPro.
DR GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR GO; GO:0060396; P:growth hormone receptor signaling pathway; IEA:UniProt.
DR CDD; cd00063; FN3; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR025871; GHBP.
DR InterPro; IPR015152; Growth/epo_recpt_lig-bind.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003528; Long_hematopoietin_rcpt_CS.
DR PANTHER; PTHR23036; CYTOKINE RECEPTOR; 1.
DR PANTHER; PTHR23036:SF108; GROWTH HORMONE RECEPTOR; 1.
DR Pfam; PF09067; EpoR_lig-bind; 1.
DR Pfam; PF00041; fn3; 1.
DR Pfam; PF12772; GHBP; 1.
DR SMART; SM00060; FN3; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
DR PROSITE; PS50853; FN3; 1.
DR PROSITE; PS01352; HEMATOPO_REC_L_F1; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..638
FT /note="Growth hormone receptor"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003421789"
FT TRANSMEM 265..287
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 151..254
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 573..592
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 638 AA; 71091 MW; 058EC52B8A3C48CE CRC64;
MDLWQLLLTV ALAGSSDAFS GSEATPATLG RASESLQRVH PGLGTNSSGK PKFTKCRSPE
LETFSCHWTD GVHHGLKSPG SVQLFYIRRN TQEWTQEWKE CPDYVSAGEN SCYFNSSYTS
IWIPYCIKLT NNGGMVDQKC FSVEEIVQPD PPIGLNWTLL NVSLTGIHAD IQVRWEPPPN
ADVQKGWIVL EYELQYKEVN ETQWKMMDPV LSTSVPVYSL RLDKEYEVRV RSRQRSSEKY
GEFSEVLYVT LPQMSPFTCE EDFRFPWFLI IIFGIFGLTV MLFVFIFSKQ QRIKMLILPP
VPVPKIKGID PDLLKEGKLE EVNTILAIQD SYKPEFYNDD SWVEFIELDI DDPDEKTEGS
DTDRLLSNSH QKSLSVLAAK DDDSGRTSCY EPDILENDFN ASDGCDGNSE VAQPQRLKGE
ADLLCLDQKN QNNSPYHDVS PAAQQPEVVL AEEDKPRPLL TGEIESTLQA APSQLSNPNS
LANIDFYAQV SDITPAGSVV LSPGQKNKAG NSQCDAHPEV VSLCQTNFIM DNAYFCEADA
KKCIAVAPHV DVESRVEPSF NQEDIYITTE SLTTTAERSG TAEDAPGSEM PVPDYTSIHL
VQSPQGLVLN AATLPLPDKE FLSSCGYVST DQLNKILP
//
