ID G1SVK0_RABIT Unreviewed; 601 AA.
AC G1SVK0;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 2.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=Patatin like phospholipase domain containing 1 {ECO:0000313|Ensembl:ENSOCUP00000007460.3};
GN Name=PNPLA1 {ECO:0000313|Ensembl:ENSOCUP00000007460.3};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000007460.3, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000007460.3, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000007460.3,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000007460.3}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000007460.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAGW02017830; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02017831; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02017832; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02017833; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_008261056.1; XM_008262834.2.
DR AlphaFoldDB; G1SVK0; -.
DR PaxDb; 9986-ENSOCUP00000007460; -.
DR Ensembl; ENSOCUT00000008631.4; ENSOCUP00000007460.3; ENSOCUG00000008628.4.
DR GeneID; 100339908; -.
DR KEGG; ocu:100339908; -.
DR CTD; 285848; -.
DR eggNOG; KOG3773; Eukaryota.
DR GeneTree; ENSGT00940000160828; -.
DR HOGENOM; CLU_039943_0_0_1; -.
DR OMA; PESTCEW; -.
DR OrthoDB; 5395310at2759; -.
DR TreeFam; TF314272; -.
DR Proteomes; UP000001811; Chromosome 12.
DR Bgee; ENSOCUG00000008628; Expressed in skin of back and 2 other cell types or tissues.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-UniRule.
DR CDD; cd07219; Pat_PNPLA1; 1.
DR Gene3D; 3.40.1090.10; Cytosolic phospholipase A2 catalytic domain; 2.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR033562; PLPL.
DR InterPro; IPR039180; PNPLA1.
DR InterPro; IPR002641; PNPLA_dom.
DR PANTHER; PTHR12406; CALCIUM-INDEPENDENT PHOSPHOLIPASE A2 IPLA2 -RELATED; 1.
DR PANTHER; PTHR12406:SF23; OMEGA-HYDROXYCERAMIDE TRANSACYLASE; 1.
DR Pfam; PF01734; Patatin; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR PROSITE; PS51635; PNPLA; 1.
PE 4: Predicted;
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811}.
FT DOMAIN 16..185
FT /note="PNPLA"
FT /evidence="ECO:0000259|PROSITE:PS51635"
FT REGION 310..541
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 555..582
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 329..366
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 414..460
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 562..582
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 601 AA; 65067 MW; EF1A20F7AD2E08DF CRC64;
MNEQVFKGDP DTPHSISFSG SGFLSFYQAG AVDALRDLAP RMLDTAHRFA GTSAGAVIAA
LVICGIEMDE YLRVLNVGVA EVKKSFLGPL SPSCKMVQMM RQFLYRVLPE DSYKAATGRL
HVSLTRFTDG ESVVVSEYTS KEELIEALYC SCFVPVYCGF IPPTYRGVRY IDGGFTDMQP
CSFWTDSITI STFSGQQDIC PRDCPAIFND FRLFNYSFQF SLENLARMTH ALFPPDLVIL
HDYYYRGYDD AVLYLRRLNA AYLSSPSKRV IFPRVEVYCQ IELALGNECP ERSQLDLQTQ
QVRLEEPVHH TQWAPKGDGR GGPGPAVSPP LQTSESTCGC PVESPVSPTV SSLEQSPASP
LVSSLACSPT DLLPEPPMSP PDMHLNSSSA PGLSPPITPP GLLPVSPQRQ VHMPGSPLRP
PPSQSSTSPC LAPGPPAVGP SQPPPRDSSP APPAQPCVEE LGPEQPPASP ASSSPKGTAL
RVQPKETISK ASAPDRPAGD SCWVTKVFKK SKPKTSSPRR GFPRPPKKPS SDMQSAPCPL
NLSLLSTSKM VWISYRPHPS RTQEHSCPEE AGSQERKPEL PAARAEPAAC ACLMPSLTPG
V
//
