ID G1SXI2_RABIT Unreviewed; 2358 AA.
AC G1SXI2;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=Tetratricopeptide repeat domain 28 {ECO:0000313|Ensembl:ENSOCUP00000008265.4};
GN Name=TTC28 {ECO:0000313|Ensembl:ENSOCUP00000008265.4};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000008265.4, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000008265.4, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke {ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000008265.4}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000008265.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR Ensembl; ENSOCUT00000009589.4; ENSOCUP00000008265.4; ENSOCUG00000009570.4.
DR GeneTree; ENSGT00940000156428; -.
DR HOGENOM; CLU_000553_0_0_1; -.
DR Proteomes; UP000001811; Unplaced.
DR Bgee; ENSOCUG00000009570; Expressed in aorta and 15 other cell types or tissues.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 5.
DR InterPro; IPR024983; CHAT_dom.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR10098; RAPSYN-RELATED; 1.
DR PANTHER; PTHR10098:SF106; TETRATRICOPEPTIDE REPEAT PROTEIN 28; 1.
DR Pfam; PF12770; CHAT; 1.
DR Pfam; PF13424; TPR_12; 9.
DR Pfam; PF13176; TPR_7; 3.
DR SMART; SM00028; TPR; 23.
DR SUPFAM; SSF48452; TPR-like; 6.
DR PROSITE; PS50005; TPR; 11.
DR PROSITE; PS50293; TPR_REGION; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339}.
FT REPEAT 25..58
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 227..260
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 267..300
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 307..340
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 427..460
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 507..540
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 547..580
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 790..823
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 870..903
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 910..943
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 990..1023
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT DOMAIN 1303..1625
FT /note="CHAT"
FT /evidence="ECO:0000259|Pfam:PF12770"
FT REGION 1905..2228
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2282..2358
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 883..910
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1991..2042
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2056..2070
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2106..2122
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2133..2174
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2188..2222
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2287..2304
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2358 AA; 256316 MW; 22E6ADBBD92D0B63 CRC64;
PSPEITIRLV TAQYNNKACF ISPHFQAYFR QGVALQYLGR HADALAAFAS GLAQDPKSLQ
LLVGMVEAAM KSPMRDSLEP TYQQLQKMKL DKSPFVVVSV VGQELLTAGH HGASVVVLEA
ALKIGTCSLK LRGSVFSALS SAYWSLGNTE KSTGYMQQDL DVAKTLGDQT GECRAHGNLG
SAFFSKGNYR EALTSHRHQL VLAMKLKDRE VGSSPVTEDI LNHGAASSAL SSLGHVYTAI
GDYPNALASH KQCVLLAKQS KDELSEAREL GNMGAVYIAM GDFENAVQCH EQHLKIAKDL
GNKREEARAY SNLGSAYHYR RNFDKAMSYH NYVLELAQEL VEKAIEMRAY AGLGHAARCM
QDLERAKQYH EQQLSIAEDL KDRAAEGRAS SNLGIIHQMK GDYDTALKLH KTHLCIAQEL
SDYAAQGRAY GNMGNAYNAL GMYDQAVKYH RQELQISMEV NDRASQASTH GNLAVAYQAL
GAHDRALQHY QNHLNIAREL RDIQSEARAL SNLGNFHCSR GEYGQAAPYY EQYLRLAPDL
QDMEGEGKVC HNLGYAHYCL GNYQEAVKYY EQDLALAKDL HDKLSQAKAY CNLGLAFKAL
LNFSKAEECQ KYLLSLAQSL NNSQAKFRAL GNLGDIFICK KDINGAIKFY EQQLGLAHHV
KDRRLEASAY AALGTAYRMI QKHDKALGYH TQELEVYQEL SDLPGECRAH GHLAAVYMAL
GKYTMAFKCY EEQLELGQKL KDPSLEAQVY GNMGITKMNM NVMEEAIGYF EQQLAMLQQL
SGNESVLDRG RAYGNLGDCY EALGDYEEAI KYYEQYLSVA QSLNRMQDQA KAYRGLGNGH
RAMGSLQQAL VCFEKRLVVA HELGEAFNKA QAYGELGSLH SQLGNYEQAI SCLERQLNIA
REMKDRALES DAACGLGGVY QQMGEYDTAL QYHQLDLQIA EETNNPTCQG RAYGNLGLTY
ESLGTFERAV VYQEQHLSIA AQMNDLVAKT VSYSSLGRTH HALQNYSQAV MYLQEGLRLA
EQLGRREDEA KIRHGLGLSL WASGNLEEAQ HQLYRASALF ETIRHEAQLS TDYKLSLFDL
QTSSYQALQR VLVSLGHHDE ALAVAERGRT RAFADLLVER QTGQQDSDPY SPVTIDQILE
LVNSQRGLVL YYSLAAGYLY SWLLAPGAGI LKFHEHYLGD GTVESSGDFQ AGSSAALPSV
TSSALEHHIA SVREALGVES YYSRACASSE TESEAGDIMD QQLEEMNSKL NSVTDPTGFL
RMVRRNNLFN RSCQSVTSLF STASPAKDGT SSLPRRQSAL AKPPLRALYD LLIAPMEGGL
MHSSGPVGRH RQLVLVLEGE LYLIPFALLK GSSSNEYLYE RFALIAVPAI RSLSPHSKTQ
LRKSPPTYSS STSMAAVIGN PKLPSAVMDR WLWGPMPAAE EEAYMVSELL GCQPLVGSVA
TKERVMSALT QAECVHFATH ISWKLSALVL TPSADGNPGS SKSSFGHPYT IPESLRVQDD
ASDAESISDC PPLQELLLTA ADVLDLRLPV KLVVLGSSQE SNGRVTADGV IALTRAFLAA
GAQCVLVSLW PVPVAASKMF IHAFYSSLLN GLKASAALGE AMKAVQSSKA FAHPSHWAGF
LLIGSDALTE ILQHPERARD ALRVLLHLVE KSLQRIQNGQ RNAMYTSQQS VENKVGGIPG
WQALLTAVGF RLDPPASGLP AAVFFPTSDP GDRLQQCSST LQSLLGLPNP ALQALCKLIT
ASETGEQLIS RAVKNMVGML HQVLVQLQAG EKEQDFASAP IQVSISVQLW RLPGCHEFLA
ALGFDLCEVG QEEVTLKTGK QASRRAVHFA LQSLLALFDS TELPKRLSLD SSSSLESLAS
AQSVSNALPL GYQQPPFSPT GVDSMASDAI SVYSLSSIAS SMSFVSKPEA GPEGGGPRPK
NAHPQRSTLP RGQLSPQSRP AGHRDEEEYE GFSIISTEPL AYHENRKGQG RFSPDHRAPR
GGPAGGVKVS VSSKGSVSTP SSPVKMTLIP SPNSPFQKVG KLASSDTGES DQSSTETDST
VKSQEEGNPK LEPQELAQKI LEETHSHLMA VERLQRGGQA GKGLGAEDAR PAPGGAAVFR
ASETSAFSRP VLSHQKNQAS PVTGRPKPPA RSSSLPKVSS GYSSPAASEA SVKDSPSQHS
GRPSPGSDSQ ASLAEQPLFK LKYPSSPYSA HISKSPSSGH QSPAGSAPSP ALSYSSAGSA
RSSPADAPDI DKLKMAAIDE KVQAVHNLKM FWQSAPQHSP GPMKLFRGTP GTMASKRDVL
SLLNLSPRHN KKEEGADKLE LQELSTQQRD GAPPQAPPNG HWRPEPAGPA SAARPLRLPS
GNGYKFLSPG RFFPSSKC
//
