ID G1SXK6_RABIT Unreviewed; 442 AA.
AC G1SXK6;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 71.
DE RecName: Full=PDZ and LIM domain protein 7 {ECO:0000256|ARBA:ARBA00039368};
GN Name=LMAN2 {ECO:0000313|Ensembl:ENSOCUP00000008294.3};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000008294.3, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000008294.3, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000008294.3,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000008294.3}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000008294.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAGW02066613; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02066614; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02066615; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02066616; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02066617; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02066618; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02066619; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02066620; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02066621; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02066622; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR PaxDb; 9986-ENSOCUP00000008294; -.
DR Ensembl; ENSOCUT00000009624.4; ENSOCUP00000008294.3; ENSOCUG00000022519.3.
DR eggNOG; KOG1703; Eukaryota.
DR GeneTree; ENSGT00940000158355; -.
DR HOGENOM; CLU_001357_8_1_1; -.
DR TreeFam; TF106408; -.
DR Proteomes; UP000001811; Chromosome 3.
DR Bgee; ENSOCUG00000022519; Expressed in uterus and 16 other cell types or tissues.
DR ExpressionAtlas; G1SXK6; baseline.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd09452; LIM1_Enigma; 1.
DR CDD; cd09456; LIM2_Enigma; 1.
DR CDD; cd09458; LIM3_Enigma; 1.
DR CDD; cd00992; PDZ_signaling; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 2.10.110.10; Cysteine Rich Protein; 3.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR001781; Znf_LIM.
DR PANTHER; PTHR24214:SF0; PDZ AND LIM DOMAIN PROTEIN 7; 1.
DR PANTHER; PTHR24214; PDZ AND LIM DOMAIN PROTEIN ZASP; 1.
DR Pfam; PF00412; LIM; 3.
DR Pfam; PF00595; PDZ; 1.
DR SMART; SM00132; LIM; 3.
DR SMART; SM00228; PDZ; 1.
DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 4.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR PROSITE; PS00478; LIM_DOMAIN_1; 1.
DR PROSITE; PS50023; LIM_DOMAIN_2; 3.
DR PROSITE; PS50106; PDZ; 1.
PE 4: Predicted;
KW LIM domain {ECO:0000256|ARBA:ARBA00023038, ECO:0000256|PROSITE-
KW ProRule:PRU00125}; Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00125};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00125}.
FT DOMAIN 9..85
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 265..323
FT /note="LIM zinc-binding"
FT /evidence="ECO:0000259|PROSITE:PS50023"
FT DOMAIN 324..383
FT /note="LIM zinc-binding"
FT /evidence="ECO:0000259|PROSITE:PS50023"
FT DOMAIN 384..442
FT /note="LIM zinc-binding"
FT /evidence="ECO:0000259|PROSITE:PS50023"
FT REGION 81..208
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 162..176
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 188..202
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 442 AA; 48082 MW; A248C621349706B9 CRC64;
MDSFKVLLEG PAPWGFRLQG GKDFNVPLSI SRLTPGGKAA QAGVAVGDWV LSIDGENAGG
LTHIEAQNKI RACGERLSLG LSRAQPAQSK PQKALAPAAD PPRYTFAPSA SLNKTARPFG
APPPADSAPQ QNXMEDTEDW RPRPGTASRS FRILAHLTGT EFMQDPDEEH LKKSSQVPRT
EIPAPASTTP QEPWPGPTTP SATSRPPWAV DPAFAERYAP DKTSTVLTRH SQPATPTPLQ
NRTSIVQAAA GGGTGGGGGS NGKTPVCHQC HKVIRGRYLV ALGHAYHPEE FVCSQCGKVL
EEGGFFEEKG AIFCPPCYDV RYAPSCAKCK KKITGEIMHA LKMTWHVHCF TCTACKTPIR
NRAFYMEEGA PYCERDYEKM FGTKCRGCDF KIDAGDRFLE ALGFSWHDTC FVCAICQINL
EGKTFYSKKD KPLCKSHAFS HV
//
