ID G1SXM3_RABIT Unreviewed; 665 AA.
AC G1SXM3;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 58.
DE RecName: Full=Pescadillo homolog {ECO:0000256|HAMAP-Rule:MF_03028};
GN Name=PES1 {ECO:0000256|HAMAP-Rule:MF_03028,
GN ECO:0000313|Ensembl:ENSOCUP00000008314.3};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000008314.3, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000008314.3, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000008314.3,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000008314.3}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000008314.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Component of the PeBoW complex, which is required for
CC maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S
CC ribosome. {ECO:0000256|HAMAP-Rule:MF_03028}.
CC -!- SUBUNIT: Component of the PeBoW complex, composed of BOP1, PES1 and
CC WDR12. Within the PeBoW complex BOP1 interacts directly with PES1 and
CC WDR12. The PeBoW complex also associates with the 66S pre-ribosome.
CC Interacts with IRS1 and UBTF. May interact with MAP1B.
CC {ECO:0000256|HAMAP-Rule:MF_03028}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000256|HAMAP-
CC Rule:MF_03028}. Nucleus, nucleoplasm {ECO:0000256|HAMAP-Rule:MF_03028}.
CC Chromosome {ECO:0000256|HAMAP-Rule:MF_03028}. Note=Appears to localize
CC to the periphery of metaphase chromosomes during mitosis and to the
CC prenucleolar bodies that form in mitotic cells prior to the actual
CC nucleoli. {ECO:0000256|HAMAP-Rule:MF_03028}.
CC -!- PTM: Sumoylated. {ECO:0000256|HAMAP-Rule:MF_03028}.
CC -!- SIMILARITY: Belongs to the pescadillo family. {ECO:0000256|HAMAP-
CC Rule:MF_03028}.
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DR EMBL; AAGW02067652; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02067653; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02067654; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02067655; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1SXM3; -.
DR Ensembl; ENSOCUT00000009648.4; ENSOCUP00000008314.3; ENSOCUG00000009646.4.
DR eggNOG; KOG1471; Eukaryota.
DR GeneTree; ENSGT00390000002626; -.
DR TreeFam; TF313988; -.
DR Proteomes; UP000001811; Chromosome 21.
DR Bgee; ENSOCUG00000009646; Expressed in liver and 15 other cell types or tissues.
DR ExpressionAtlas; G1SXM3; baseline.
DR GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0030687; C:preribosome, large subunit precursor; IEA:UniProtKB-UniRule.
DR GO; GO:0043021; F:ribonucleoprotein complex binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000466; P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR Gene3D; 3.40.50.10190; BRCT domain; 1.
DR Gene3D; 3.40.525.10; CRAL-TRIO lipid binding domain; 1.
DR Gene3D; 2.60.120.680; GOLD domain; 1.
DR HAMAP; MF_03028; Pescadillo; 1.
DR InterPro; IPR036420; BRCT_dom_sf.
DR InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR InterPro; IPR009038; GOLD_dom.
DR InterPro; IPR036598; GOLD_dom_sf.
DR InterPro; IPR010613; PES.
DR PANTHER; PTHR12221; PESCADILLO - RELATED; 1.
DR PANTHER; PTHR12221:SF6; PESCADILLO HOMOLOG; 1.
DR Pfam; PF06732; Pescadillo_N; 1.
DR SUPFAM; SSF52087; CRAL/TRIO domain; 1.
DR SUPFAM; SSF101576; Supernatant protein factor (SPF), C-terminal domain; 1.
DR PROSITE; PS50866; GOLD; 1.
PE 3: Inferred from homology;
KW Chromosome {ECO:0000256|HAMAP-Rule:MF_03028};
KW Nucleus {ECO:0000256|HAMAP-Rule:MF_03028};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW Ribosome biogenesis {ECO:0000256|HAMAP-Rule:MF_03028};
KW rRNA processing {ECO:0000256|HAMAP-Rule:MF_03028};
KW Ubl conjugation {ECO:0000256|HAMAP-Rule:MF_03028}.
FT DOMAIN 512..643
FT /note="GOLD"
FT /evidence="ECO:0000259|PROSITE:PS50866"
FT REGION 396..485
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 418..433
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 456..477
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 665 AA; 75335 MW; 17635D1E692F6D74 CRC64;
MGGLEKKKYE RGSATNYITR NKARKKLQLS LADFRRLCIL KGIYPHEPKH KKKVNKGSTA
ARTFYLLKDI KFLLHEPIVS KFREYKVFVR KLRKAYGKSE WNTVERLKDN KPSYKLDHIV
KERYPTFIDA LRDLDDALSM CFLFSTFPRT GKCHVQTIQL CRRLTVEFLH YVIAARALRK
VFLSIKGIYY QAEVLGQPIV WITPYTFSHD HPTDVDYRVM ATFTEFYTTL LGFVNFRLYQ
SLNLQYPPKL EGQAHTDRKV SEDTYALDSE SSMEKLAALS ASLARVVVPA AEEEAEVDEF
PADGEVAAQE QERRKELEAQ EKHRKLFEGL KFFLNREVPR EALAFVISSF GGSYPRCGPA
VLRQLEPWES RAGTDSVCRE REAQLGACPV SVPGPRIFRS QSPGTWPLER RGRVWRSSES
GQRNQQGTRH RATQPLFPRQ WGTGSVARSA PAPGQLLAQP APPSVDPHPP MQTPLSPPPH
ADNWKQDLHK FISPDQLPAV FGGTMTDPDG NPKCLTKINP GGEVPKSYYK RQQVRLQYEH
TVSVGRGSSQ QVENEILFPG CVLRWQFASD GGDIGFGVFL KTKMGERQRA GEMTEVLPSQ
HYNAHLVPED GSLTCAEAGV YVLRFDNTYS LVHAKKVSYT VEVLLPDEAS QEKLQSLRAS
SPSAQ
//
