ID G1SY05_RABIT Unreviewed; 406 AA.
AC G1SY05;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 64.
DE RecName: Full=Sorting nexin-30 {ECO:0000256|ARBA:ARBA00015234};
GN Name=SNX30 {ECO:0000313|Ensembl:ENSOCUP00000008472.4};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000008472.4, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000008472.4, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000008472.4,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000008472.4}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000008472.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBUNIT: Heterodimer; heterodimerizes with SNX4.
CC {ECO:0000256|ARBA:ARBA00038663}.
CC -!- SUBCELLULAR LOCATION: Early endosome membrane
CC {ECO:0000256|ARBA:ARBA00004469}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004469}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004469}. Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004125}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004125}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004125}.
CC -!- SIMILARITY: Belongs to the sorting nexin family.
CC {ECO:0000256|ARBA:ARBA00010883}.
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DR EMBL; AAGW02034012; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02034013; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02034014; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02034015; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02034016; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02034017; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02034018; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02034019; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02034020; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02034021; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1SY05; -.
DR SMR; G1SY05; -.
DR STRING; 9986.ENSOCUP00000008472; -.
DR PaxDb; 9986-ENSOCUP00000008472; -.
DR Ensembl; ENSOCUT00000009833.4; ENSOCUP00000008472.4; ENSOCUG00000009834.4.
DR eggNOG; KOG2273; Eukaryota.
DR GeneTree; ENSGT00940000158994; -.
DR HOGENOM; CLU_040655_1_0_1; -.
DR InParanoid; G1SY05; -.
DR TreeFam; TF328543; -.
DR Proteomes; UP000001811; Chromosome 1.
DR Bgee; ENSOCUG00000009834; Expressed in upper lobe of left lung and 16 other cell types or tissues.
DR GO; GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:2000786; P:positive regulation of autophagosome assembly; IEA:Ensembl.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR CDD; cd07667; BAR_SNX30; 1.
DR CDD; cd06860; PX_SNX7_30_like; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR028649; SNX30_BAR.
DR PANTHER; PTHR45949:SF1; SORTING NEXIN-30; 1.
DR PANTHER; PTHR45949; SORTING NEXIN-4; 1.
DR Pfam; PF00787; PX; 1.
DR SMART; SM00312; PX; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF64268; PX domain; 1.
DR PROSITE; PS50195; PX; 1.
PE 3: Inferred from homology;
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW Transport {ECO:0000256|ARBA:ARBA00022927}.
FT DOMAIN 58..179
FT /note="PX"
FT /evidence="ECO:0000259|PROSITE:PS50195"
FT REGION 21..41
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 406 AA; 46647 MW; 6104CBEB34809769 CRC64;
MQDAQAPACL PVPGLWSSES RDLILPNGGT PAGTSSPASS SSLLNRLQLD DDIDGETRDL
FVTVDDPKKH VCTMETYITY RITTKSTRVE FDLPEYSVRR RYQDFDWLRN KLEESQPTHL
IPPLPEKFVV KGVVDRFSEE FVETRRKALD KFLKRITDHP VLSFNEHFNV FLTAKDLNAY
KKQGMALLTR VGESVKHVTG GYKLRSRPLE FAAIGDYLDT FALKLGTIDR IAQRIIKEEI
EYLVELREYG PVYSTWSALE GELAEPLEGV SACIGNCSAA LEELTDDMTE DFLPVLREYI
LYSDSMKSVL KKRDQVQAEY EAKLEAVALR KEDRPKVPAD VEKCQDRMEC FNADLKADME
RWQNNKRQDF RQLLMGMADK NIQYYEKCLM AWESIIPLLQ EKQEAK
//
