ID G1SYE9_RABIT Unreviewed; 716 AA.
AC G1SYE9;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=Engulfment and cell motility 3 {ECO:0000313|Ensembl:ENSOCUP00000008640.3};
GN Name=ELMO3 {ECO:0000313|Ensembl:ENSOCUP00000008640.3};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000008640.3, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000008640.3, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000008640.3,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000008640.3}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000008640.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Involved in cytoskeletal rearrangements required for
CC phagocytosis of apoptotic cells and cell motility. Acts in association
CC with DOCK1 and CRK. Was initially proposed to be required in complex
CC with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine
CC nucleotide exchange factor (GEF) activity of DOCK1.
CC {ECO:0000256|ARBA:ARBA00024863}.
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DR EMBL; AAGW02067912; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02067913; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02067914; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02067915; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02067916; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02067917; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02067918; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_008255667.1; XM_008257445.2.
DR AlphaFoldDB; G1SYE9; -.
DR PaxDb; 9986-ENSOCUP00000008640; -.
DR Ensembl; ENSOCUT00000010030.3; ENSOCUP00000008640.3; ENSOCUG00000010030.4.
DR eggNOG; KOG2999; Eukaryota.
DR GeneTree; ENSGT00940000159455; -.
DR OrthoDB; 4872856at2759; -.
DR TreeFam; TF312966; -.
DR Proteomes; UP000001811; Chromosome 5.
DR Bgee; ENSOCUG00000010030; Expressed in adult mammalian kidney and 14 other cell types or tissues.
DR ExpressionAtlas; G1SYE9; baseline.
DR GO; GO:0017124; F:SH3 domain binding; IEA:UniProtKB-KW.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0006909; P:phagocytosis; IEA:UniProtKB-KW.
DR Gene3D; 6.10.250.810; -; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR024574; ELMO_ARM.
DR InterPro; IPR006816; ELMO_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR12771; ENGULFMENT AND CELL MOTILITY; 1.
DR PANTHER; PTHR12771:SF16; ENGULFMENT AND CELL MOTILITY PROTEIN 3; 1.
DR Pfam; PF11841; ELMO_ARM; 1.
DR Pfam; PF04727; ELMO_CED12; 1.
DR Pfam; PF16457; PH_12; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS51335; ELMO; 1.
PE 4: Predicted;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Phagocytosis {ECO:0000256|ARBA:ARBA00022907};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW SH3-binding {ECO:0000256|ARBA:ARBA00023036}.
FT DOMAIN 307..475
FT /note="ELMO"
FT /evidence="ECO:0000259|PROSITE:PS51335"
SQ SEQUENCE 716 AA; 81130 MW; AA3C5EFAA263D71D CRC64;
MAPPRNVVKI AVQMRDAVPQ LIQLDQAKPL GAVLKEVCDA WSLTHSERYA LQFADGHRKY
ITENNRTEIK NGSILCLSTA PDLEAERLLG GLQSGSREGR REALRHLVLL ASDMTFAQEV
ISRDGLQRVG TIIEDGDDLG EVLALGLRAF LELMEHGVVS WETLSIPFVR KVVSYVNINL
MDASVQPLAL RLLESVTLSS PALGQLVKSE VPLDRLLVHL QVMNQQLQTK AMALLTALLQ
GASPAERKHM LDYLWQRNFR QFIYKNIIHS AVPLGDEMAH HLYVLQALTL GLLEPRMRTP
LDPYSQEQRE QLQALRQAAF EPEGESLSAD RRRSLCAREF RKLGFTNSNP AQDLERVPPG
LLALDNMVYF SRHAPSAYSR FVLENSSRED RHECPFARSS IQLTVLLCEL LRVGEPCSET
AQDFSPMFFG QDQSFHELFC VAIQLLNKTW KEMRATQEDF DKVMQVVREQ LARTLALKPT
SLELFRTKVN ALTYGEVLRL RQTERLHQEG TLAPPILELR EKLKPELMGL IRQQRLLRLC
EGTLFRKISS RRRQDKLWFC CLSPNHKVLQ YGDVEEGTSP PPPESLPEQL PVADIRGLLT
GRDCPHVREK GSGKQNKDFC KRAFSVSYAR GEEEASLNFI APSNREFHLW IDGLSALLGS
PMGSEQTRLD LEQLLTMETK LRLLELENVP IPEQPPPIPP PPTNFNFCYD CSVTEP
//
