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Database: UniProt
Entry: G1SYY1_RABIT
LinkDB: G1SYY1_RABIT
Original site: G1SYY1_RABIT 
ID   G1SYY1_RABIT            Unreviewed;       919 AA.
AC   G1SYY1;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   28-MAR-2018, entry version 34.
DE   RecName: Full=Non-lysosomal glucosylceramidase {ECO:0000256|PIRNR:PIRNR028944};
DE            Short=NLGase {ECO:0000256|PIRNR:PIRNR028944};
DE            EC=3.2.1.45 {ECO:0000256|PIRNR:PIRNR028944};
GN   Name=GBA2 {ECO:0000313|Ensembl:ENSOCUP00000008843};
OS   Oryctolagus cuniculus (Rabbit).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae;
OC   Oryctolagus.
OX   NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000008843, ECO:0000313|Proteomes:UP000001811};
RN   [1] {ECO:0000313|Ensembl:ENSOCUP00000008843, ECO:0000313|Proteomes:UP000001811}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Thorbecke {ECO:0000313|Proteomes:UP000001811};
RX   PubMed=21993624; DOI=10.1038/nature10530;
RA   Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J.,
RA   Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E.,
RA   Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J.,
RA   Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S.,
RA   Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I.,
RA   Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I.,
RA   Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J.,
RA   Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D.,
RA   Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L.,
RA   Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S.,
RA   Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G.,
RA   Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K.,
RA   Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T.,
RA   Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J.,
RA   Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S.,
RA   Pedersen J.S., Lander E.S., Kellis M.;
RT   "A high-resolution map of human evolutionary constraint using 29
RT   mammals.";
RL   Nature 478:476-482(2011).
RN   [2] {ECO:0000313|Ensembl:ENSOCUP00000008843}
RP   IDENTIFICATION.
RC   STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000008843};
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- FUNCTION: Non-lysosomal glucosylceramidase that catalyzes the
CC       conversion of glucosylceramide to free glucose and ceramide.
CC       {ECO:0000256|PIRNR:PIRNR028944}.
CC   -!- CATALYTIC ACTIVITY: D-glucosyl-N-acylsphingosine + H(2)O = D-
CC       glucose + N-acylsphingosine. {ECO:0000256|PIRNR:PIRNR028944}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000256|PIRNR:PIRNR028944}; Peripheral membrane protein
CC       {ECO:0000256|PIRNR:PIRNR028944}; Cytoplasmic side
CC       {ECO:0000256|PIRNR:PIRNR028944}. Golgi apparatus membrane
CC       {ECO:0000256|PIRNR:PIRNR028944}; Peripheral membrane protein
CC       {ECO:0000256|PIRNR:PIRNR028944}; Cytoplasmic side
CC       {ECO:0000256|PIRNR:PIRNR028944}. Note=Not localized to lipid
CC       rafts. {ECO:0000256|PIRNR:PIRNR028944}.
CC   -!- SIMILARITY: Belongs to the non-lysosomal glucosylceramidase
CC       family. {ECO:0000256|PIRNR:PIRNR028944}.
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DR   EMBL; AAGW02033515; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9986.ENSOCUP00000008843; -.
DR   Ensembl; ENSOCUT00000010254; ENSOCUP00000008843; ENSOCUG00000010248.
DR   eggNOG; KOG2119; Eukaryota.
DR   eggNOG; COG4354; LUCA.
DR   GeneTree; ENSGT00390000010998; -.
DR   InParanoid; G1SYY1; -.
DR   OMA; HDYQDSS; -.
DR   OrthoDB; EOG091G01JK; -.
DR   TreeFam; TF313888; -.
DR   Proteomes; UP000001811; Chromosome 1.
DR   Bgee; ENSOCUG00000010248; -.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:Ensembl.
DR   GO; GO:0008422; F:beta-glucosidase activity; IEA:Ensembl.
DR   GO; GO:0004348; F:glucosylceramidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0008206; P:bile acid metabolic process; IEA:Ensembl.
DR   GO; GO:0021954; P:central nervous system neuron development; IEA:Ensembl.
DR   GO; GO:0006680; P:glucosylceramide catabolic process; IEA:InterPro.
DR   GO; GO:0016139; P:glycoside catabolic process; IEA:Ensembl.
DR   Gene3D; 1.50.10.10; -; 1.
DR   InterPro; IPR008928; 6-hairpin_glycosidase_sf.
DR   InterPro; IPR012341; 6hp_glycosidase-like_sf.
DR   InterPro; IPR014551; B_Glucosidase_GBA2-typ.
DR   InterPro; IPR006775; GH116_catalytic.
DR   InterPro; IPR024462; GH116_N.
DR   Pfam; PF04685; DUF608; 1.
DR   Pfam; PF12215; Glyco_hydr_116N; 1.
DR   PIRSF; PIRSF028944; Beta_gluc_GBA2; 1.
DR   SUPFAM; SSF48208; SSF48208; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001811};
KW   Endoplasmic reticulum {ECO:0000256|PIRNR:PIRNR028944};
KW   Glycosidase {ECO:0000256|PIRNR:PIRNR028944};
KW   Golgi apparatus {ECO:0000256|PIRNR:PIRNR028944};
KW   Hydrolase {ECO:0000256|PIRNR:PIRNR028944};
KW   Lipid metabolism {ECO:0000256|PIRNR:PIRNR028944};
KW   Membrane {ECO:0000256|PIRNR:PIRNR028944};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001811}.
FT   DOMAIN      149    453       Glyco_hydr_116N. {ECO:0000259|Pfam:
FT                                PF12215}.
FT   DOMAIN      519    884       DUF608. {ECO:0000259|Pfam:PF04685}.
SQ   SEQUENCE   919 AA;  103191 MW;  4DCDFD7F52D959DA CRC64;
     VGTQHPRNMG TGVPASEQIS CAKGEARCPE DTGGTEAVHV PDCESPEASR SPNEPGSCDP
     EDSGQLMASY EGTARGYRVP PFGWRICLAH EFAEKRKPFQ ANNVSLSNLV KHLGMGLRYL
     KWWYRKTQVE KKTPFIDMFN CVPLRQIYGC PLGGIGGGTI TRGWRGQFCR WQLDPGMYQH
     RTVMADQFTV CLRREGRTVY QQVLSLERPS VLRSWNWGLC GYFAFYHALY PRAWTVYQLP
     GQNVTLTCRQ ITPILPHDYQ DSCLPVGVFV WDVENEGDEA LDVSIMFSMR NGLGDGDDAS
     GGLWNEPFCL ERDGQTVQGL LLHHPTVPNP YTMAVAARLT ADTTVTHVTA FDPDGTGQQV
     WQDLLQDGQL DSPAGQSTPS QKGVGIAGAV CVSSKLPPRG QCRLEFSLAW DMPKIMFGAK
     GQVYHRRYTR FFGPDGDAAP ALSHYALCRY ADWEDRISAW QSPVLDDRSL PAWYKSALFN
     ELYFVADGGT VWLEVPEDSL PEELEGGMCQ LRPILRDYGR FGYLEGQEYR MYNTYDVHFY
     ASFALIMLWP KLELSLQYDM ALATLKEDLT RRRYLMSGVM GPVKRKNVIP HDVGDPDDEP
     WLRINAYLIH DTADWKDLNL KFVLQVYRDY YLTGDQSFLK DMWPVCLAVM ESEMKFDKDH
     DGLIENGGYA DQTYDGWVTT GPSAYCGGLW LAAVAVMVQV AALCGAQDVQ NKFAHILRRG
     QEAYERLLWN GRYYNYDSSS QPQSRSVMSD QCAGQWFLRA CGLGEGDTEV FPTPHVVRAL
     QTIFELNVQA FAGGGMGAVN GMQPHGVPDR SSVQSDEVWV GVVYGLAATM IQEGLTREGF
     LTAEGCYRTV WERLGLAFQT PEAYCQQRVF RSLAYMRPLS IWAMQLALQQ QQEKKASRQI
     VGQDRGLSKG AKSGPKELP
//
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