ID G1SZ09_RABIT Unreviewed; 1719 AA.
AC G1SZ09;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=Signal induced proliferation associated 1 like 2 {ECO:0000313|Ensembl:ENSOCUP00000008879.2};
GN Name=SIPA1L2 {ECO:0000313|Ensembl:ENSOCUP00000008879.2};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000008879.2, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000008879.2, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000008879.2,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000008879.2}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000008879.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAGW02026245; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02026246; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_002717410.1; XM_002717364.3.
DR SMR; G1SZ09; -.
DR STRING; 9986.ENSOCUP00000008879; -.
DR PaxDb; 9986-ENSOCUP00000008879; -.
DR Ensembl; ENSOCUT00000010304.4; ENSOCUP00000008879.2; ENSOCUG00000010297.4.
DR GeneID; 100348416; -.
DR KEGG; ocu:100348416; -.
DR CTD; 57568; -.
DR eggNOG; KOG3686; Eukaryota.
DR GeneTree; ENSGT00940000157388; -.
DR HOGENOM; CLU_002127_0_2_1; -.
DR InParanoid; G1SZ09; -.
DR OMA; GYRVDSY; -.
DR OrthoDB; 25782at2759; -.
DR Proteomes; UP000001811; Chromosome 16.
DR Bgee; ENSOCUG00000010297; Expressed in heart and 14 other cell types or tissues.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-UniRule.
DR GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00992; PDZ_signaling; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 6.10.140.210; -; 1.
DR Gene3D; 3.40.50.11210; Rap/Ran-GAP; 1.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR035974; Rap/Ran-GAP_sf.
DR InterPro; IPR000331; Rap/Ran_GAP_dom.
DR InterPro; IPR021818; SIPA1L_C.
DR PANTHER; PTHR15711; RAP GTPASE-ACTIVATING PROTEIN; 1.
DR PANTHER; PTHR15711:SF7; SIGNAL-INDUCED PROLIFERATION-ASSOCIATED 1-LIKE PROTEIN 2; 1.
DR Pfam; PF00595; PDZ; 1.
DR Pfam; PF21022; Rap-GAP_dimer; 1.
DR Pfam; PF02145; Rap_GAP; 1.
DR Pfam; PF11881; SPAR_C; 1.
DR SMART; SM00228; PDZ; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF111347; Rap/Ran-GAP; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50085; RAPGAP; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468, ECO:0000256|PROSITE-
KW ProRule:PRU00165}; Reference proteome {ECO:0000313|Proteomes:UP000001811}.
FT DOMAIN 592..809
FT /note="Rap-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50085"
FT DOMAIN 947..1023
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 44..68
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 357..398
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1064..1085
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1097..1242
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1324..1357
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1655..1703
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 44..61
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 357..380
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 381..398
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1110..1129
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1158..1181
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1192..1210
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1211..1238
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1327..1357
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1719 AA; 190623 MW; 51879E101828846D CRC64;
MSDPRQSQED KHKLGRASSK FKDPPRIMQS DDYFARKFKA INGNMGPTSL NASNSGESGG
PANGTPAVPK MGVRARVSEW PPKKDCSKEL TCKTLWESRS QTSYESVTSI MHNGQNDQRD
GQQEEQLDVD FVEAKYTIGD IFVHSPQRGL HPIRQRSNSD VTISDIDAED VLDQNAVNPN
TGAALHREYG STSSIDRQGL SGENFFAMLR GYRVENYDHK AMVPFGFPEF FPCDPAISPS
LHAAAQISRG EFVRISGLDY MDSALLMGRD RDKPFKRRLK SESVETSLFR KLRTVKSEHE
TFKFTSELEE GRLERGIRPW HCQRCFAHYD VQSILFNINE AMATRANVGK RKNITTGASA
ASQTQMPTGQ TGNCESPLGS KEDLNSKENL DADEGDGKSN DLVLSCPYFR NETGGEGDRR
IALSRANSSS FSSGESCSFE SSLSSHCTNA GVSVLEVPRE NQPIHREKVK RYIIEHIDLG
AYYYRKFFYG KEHQNYFGID ENLGPVAVSI RREKVEDAKE KEGSQFNYRV AFRTSELTTL
RGAILEDAIP STARHGTARG LPLKEVLEYV IPELSIQCLR QASNSPKVPE QLLKLDEQGL
SFQHKIGILY CKAGQSTEEE MYNNETAGPA FEEFLDLLGQ RVRLKGFSKY RAQLDNKTDS
TGTHSLYTTY KDYELMFHVS TLLPYMPNNR QQLLRKRHIG NDIVTIVFQE PGALPFTPKS
IRSHFQHVFV IVKVHNPCTE NVCYSVGVSR SKDVPPFGPP IPKGVTFPKS AVFRDFLLAK
VINAENAAHK SEKFRAMATR TRQEYLKDLA ENFVTTATVD TSVKFSFITL GAKKKEKVKP
RKDAHLFSIG AIMWHVIARD FGQSADIECL LGISNEFIML IEKDSKNVVF NCSCRDVIGW
TSGLMSIKVF YERGECILLS SVDNCSEDIR EIVHRLVIVT RGCETVEMTL RRNGLGQLGF
HVNFEGIVAD VEPFGFAWKA GLRQGSRLVE ICKVAVATLT HEQMIDLLRT SVTVKVVIIQ
PHDDGSPRRG CSELCRIPMV EYKLDSEGTP CEYKTPFRRN TTWHRVPTPA LQPISRASPV
PGTPDRLQCQ QLLQQAQAAI PRSTSFDRKL PDGTRSSPSN QSSSSDPGPG GSGPWRPQVG
YDGCQSPLLL EHQGSGPLEC EGAREREDAM EGSRHPETKW HGPPSKVLSS YKERALQKDG
SCKDSPNKLS HIGDKSCSSH SSSNTLSSNT SSNSDDKHFG SGDLMDPELL GLTYIKGAST
DSGIDTAPCM PTAILGPMHL TGSRSLIHSR AEQWADAADI SGPEDDPAKM YTVHGYAAAI
SSGGATEGSM GDLSEISSHS SGSHHSGSPS AHCSKNSGSL DTSKVYIVSH SSGQQVPGSM
SKPYHRQGAV NKYVIGWKKS EGSPPPEEPE VPECPGMYSE MDVMSAATQH QTVVGDAVSE
TQHVLSKEDF LKLMLPDSPL VEEGRRKFSF YGNLSPRRSL YRTLSDESIC SNRRGSSFGS
SRSSILDQAL PNDILFSTTP PYHSTLPPRT HPAPSMGSLR NEFWFSDGSL SDKSKCADPG
LMPLPDTATG LDWSHLVDAA RAFEGLDSDE ELGLLCHHTS YLDQRVASFC TMTDMQHGQE
LEGDQELPLC VDPDSGKEFM DTTGERSPST LTGKVNQLEL ILRQLQTDLR KEKQDKAVLQ
AEVQHLRQDN MRLQEESQTA TAQLRKFTEW FFNTIDKKS
//
