ID G1SZ89_RABIT Unreviewed; 1035 AA.
AC G1SZ89;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 2.
DT 27-MAR-2024, entry version 69.
DE RecName: Full=Cyclin-like domain-containing protein {ECO:0000259|SMART:SM00385};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000008975.3, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000008975.3, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke {ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000008975.3}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000008975.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the cyclin family.
CC {ECO:0000256|RuleBase:RU000383}.
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DR AlphaFoldDB; G1SZ89; -.
DR SMR; G1SZ89; -.
DR STRING; 9986.ENSOCUP00000008975; -.
DR PaxDb; 9986-ENSOCUP00000008975; -.
DR Ensembl; ENSOCUT00000010419.4; ENSOCUP00000008975.3; ENSOCUG00000010413.4.
DR eggNOG; KOG0653; Eukaryota.
DR GeneTree; ENSGT00940000160459; -.
DR HOGENOM; CLU_006366_0_0_1; -.
DR InParanoid; G1SZ89; -.
DR OMA; RCVHASM; -.
DR Proteomes; UP000001811; Unplaced.
DR Bgee; ENSOCUG00000010413; Expressed in testis and 4 other cell types or tissues.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR Gene3D; 1.10.472.10; Cyclin-like; 1.
DR InterPro; IPR039361; Cyclin.
DR InterPro; IPR013763; Cyclin-like_dom.
DR InterPro; IPR036915; Cyclin-like_sf.
DR InterPro; IPR006671; Cyclin_N.
DR InterPro; IPR048258; Cyclins_cyclin-box.
DR PANTHER; PTHR10177; CYCLINS; 1.
DR PANTHER; PTHR10177:SF601; G2_MITOTIC-SPECIFIC CYCLIN-B3; 1.
DR Pfam; PF00134; Cyclin_N; 1.
DR SMART; SM00385; CYCLIN; 1.
DR SUPFAM; SSF47954; Cyclin-like; 1.
DR PROSITE; PS00292; CYCLINS; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Cell division {ECO:0000256|ARBA:ARBA00022618};
KW Cyclin {ECO:0000256|RuleBase:RU000383};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811}.
FT DOMAIN 940..1025
FT /note="Cyclin-like"
FT /evidence="ECO:0000259|SMART:SM00385"
FT REGION 1..35
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 294..329
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 447..474
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 542..575
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 19..35
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 295..309
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 451..470
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 542..565
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1035 AA; 117485 MW; F5E9AF620B9223B9 CRC64;
MSLPKSPPVF KPNIKRPQYR KIPFRDRGHH EKRAETSCSS LQGLFTMRSA FEDLTNACQI
QPAQPKKGDN EFVKDVSKKT KGNIALSLTK TSKMNSDRYK PKPVVASSTL VLNKEKLPPV
EKSTVSKALT TEEASALKKP QVSEDEESCD HITIVRKLSS LRRRFMRCEM SLPKKTLAFQ
KENDSDNDFF LESVAVKKRS KMEEATTKKT LPSEQKTSAR KEYKFSLKDF LSTDDSSDDD
NPFGVWFLKN KKRLKTEKPT TKPLALNMCT PQRKSSHMKP LALQWVSSKD KPLTKEPLSF
NRKPAMEKES LCQEPSALQE KHASEEKSLS RETLALKKKR AIEEAPWSST IFPKKRAIGW
AVFPSMSPVL QKGCPATEEK ILPKIPLFSN KEQVTKRPVT PLQKPLVLQK NTFQEDSVNK
KLLSSKKQPI NAGEVLLKDP SALTEKRTAP QEVSFSKKKS TMEKRSPIKR SLTSKAKPTG
DEIFFSPELF SPAVTHDIAK SPSQVSLVLL AKPDSKEDSF NELLALKDKS ITERASLGSK
KLRLNQSSTE AATSRESQLS SEKEPTAQGK RGLLQKQLAL RKNITKDEEP FTKQPLALQE
KSHSKKGTLC QQRFSFKRSL TFDEECYSQG PVIFQERARM KGIILQKQPS PRKEEAPCKQ
QLSCQKKLSL EKDSLSEVPL IFREMARTND TKLREPCASQ EKPSPEKGTL NKQCLSCKKT
LTFDEECYSQ GPVILQDRAR VRGINLNEHW AFQKKSSPKK KKPIIKEALA SEAKTVINGP
FVLKEVLILN NNPTTGKGLF FEETMALGEN SFPKGATFLK TFLMVPLVNT SSDMSSTALG
SRLVTPRTPT TFGVHKSSSD SNSSICEFSC NKFSTPNGKG EQVNHELEDI NRYYNDPYVN
SAYAKDIFSY MKEREKMFIL TKYMSWQVEI SSDMRAILVD WLVEVQMGFE MSHETLYLAV
KLVDHYLNET LCKKEKLQLL GCAAFLIAAK FEVSQSSKGL ERNNQVYIQT SDIYKYKYIC
MYLYKHKYIY AYMYI
//
