ID G1SZK2_RABIT Unreviewed; 766 AA.
AC G1SZK2;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 67.
DE RecName: Full=Ion transport domain-containing protein {ECO:0000259|Pfam:PF00520};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000009105.3, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000009105.3, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000009105.3,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000009105.3}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000009105.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAGW02007398; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1SZK2; -.
DR STRING; 9986.ENSOCUP00000009105; -.
DR PaxDb; 9986-ENSOCUP00000009105; -.
DR Ensembl; ENSOCUT00000010564.4; ENSOCUP00000009105.3; ENSOCUG00000010565.4.
DR eggNOG; KOG2301; Eukaryota.
DR GeneTree; ENSGT00940000162755; -.
DR HOGENOM; CLU_019500_0_0_1; -.
DR InParanoid; G1SZK2; -.
DR TreeFam; TF328550; -.
DR Proteomes; UP000001811; Chromosome 2.
DR Bgee; ENSOCUG00000010565; Expressed in kidney and 14 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005216; F:monoatomic ion channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 2.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 1.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR46726; TWO PORE CHANNEL 3; 1.
DR PANTHER; PTHR46726:SF1; TWO PORE CHANNEL 3; 1.
DR Pfam; PF00520; Ion_trans; 2.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 55..74
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 80..100
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 121..140
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 182..205
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 217..235
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 255..278
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 400..418
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 430..446
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 458..478
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 490..508
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 520..541
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 595..617
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 624..653
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 62..280
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 398..654
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT REGION 675..703
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 675..689
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 766 AA; 87944 MW; 8D1BFB802ACEF6BC CRC64;
MRGPRPEPAE EPPDREWEQD LLLAAAYVSD AQYNRNVPFE TSPRAIRLYY FYNHWTLRVA
TYVFICVDLS LALFEEPALF PLPFLATSIV EVLCLTAFFG RLVHFAKVTP QMVFWKDTKN
ICILVTIALT LLDLIIYGSL EAVQIHGIRW SRAFRPVFLI NFPESRQIRR ALRSLRNTLP
DILYVFLLFM FSVLIFSLMA LKLFGDRGLK TAEGSPYLTN ILEIAFELYV LVTTANSPDV
MMPAYDFNRW YSLYFIAYII INTYIFMSVF LAVVYNNYRK HLKNEIRKLV YLKRHKMMEA
FKILKVKVGT EFVVREAEWK RLARMVVPDI SSSHLELLWR ISDEGQKGHV DRMNFLRLAD
LLNIQVVTVN IRKHPLEAWA PRVYQSSASL FVQRMVRHRA FVWVYDVIIL VNAIFIALDE
RSLFISRAEW FFLCLYVAEI LLKLYTYEPR AYLGRKQFWN WFDILIIIAA LVATVANATI
QSARRYNSQQ VLDIVLILRI LRLLRVIVSI QRFRVIVTTL VNIGPTVLTF AGLVFVVYYA
FAIVGMEVFQ GKVRFFDPNF TSPDALVCGN PALRGSAFAR ARYCKNNFND LASAFLLLTE
LTVVNQWHVI AGGFALATHQ AAKLYFIFFH VVVVILIVNI FIAFILEAFF VAYSLEKSEL
ETVIEKKIQE LGVGIQEEEE QDKKPTDNVG SKDGGSSGGD GDHGGAAAKG LYCRIASNKY
RTVDALLQRM FESEIAPDEE GPSLDEILSF SPSDMYVKNP NFENSA
//
