ID G1SZP7_RABIT Unreviewed; 908 AA.
AC G1SZP7;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=Neuronal PAS domain protein 3 {ECO:0000313|Ensembl:ENSOCUP00000009162.3};
GN Name=NPAS3 {ECO:0000313|Ensembl:ENSOCUP00000009162.3};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000009162.3, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000009162.3, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000009162.3,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000009162.3}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000009162.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AAGW02023884; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02023885; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02023886; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02023887; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02023888; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02023889; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02023890; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02023891; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02023892; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02023893; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1SZP7; -.
DR PaxDb; 9986-ENSOCUP00000009162; -.
DR Ensembl; ENSOCUT00000010633.4; ENSOCUP00000009162.3; ENSOCUG00000010632.4.
DR eggNOG; KOG3558; Eukaryota.
DR GeneTree; ENSGT00940000158051; -.
DR TreeFam; TF317772; -.
DR Proteomes; UP000001811; Chromosome 17.
DR Bgee; ENSOCUG00000010632; Expressed in frontal cortex and 13 other cell types or tissues.
DR ExpressionAtlas; G1SZP7; baseline.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd19732; bHLH-PAS_NPAS3_PASD6; 1.
DR CDD; cd00130; PAS; 2.
DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 2.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013767; PAS_fold.
DR InterPro; IPR013655; PAS_fold_3.
DR PANTHER; PTHR23043; HYPOXIA-INDUCIBLE FACTOR 1 ALPHA; 1.
DR PANTHER; PTHR23043:SF30; NEURONAL PAS DOMAIN-CONTAINING PROTEIN 3; 1.
DR Pfam; PF00989; PAS; 1.
DR Pfam; PF08447; PAS_3; 1.
DR SMART; SM00353; HLH; 1.
DR SMART; SM00091; PAS; 2.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 2.
DR PROSITE; PS50888; BHLH; 1.
DR PROSITE; PS50112; PAS; 2.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001811}.
FT DOMAIN 4..57
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT DOMAIN 123..187
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 304..359
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT REGION 187..223
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 422..520
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 533..612
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 628..695
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 714..755
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 195..223
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 426..476
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 490..511
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 537..562
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 566..582
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 908 AA; 97457 MW; 653D39262443B44A CRC64;
LQALRKEKSR DAARSRRGKE NFEFYELAKL LPLPAAITSQ LDKASIIRLT ISYLKMRDFA
NQGDPPWNLR MEGPPPNTSV KGIHMWKSEF CMRKTACEVI GAQRRRSPSA LAIEVFEAHL
GSHILQSLDG FVFALNQEGK FLYISETVSI YLGLSQVELT GSSVFDYVHP GDHVEMAEQL
GMKLPPGRGL LSQGTAEDGA SSASSSSQSE TPEPVESTSP SLLTTDNTLE RSFFIRMKST
LTKRGVHIKS SGYKVIHVTG RLRLRVSLSH GRTVPSQIMG LVVVAHALPP PTINEVRIDC
HMFVTRVNMD LNIIYCENRI SDYMDLTPVD IVGKRCYHFI HAEDVEGIRH SHLDLLNKGQ
CVTKYYRWMQ KNGGYIWIQS SATIAINAKN ANEKNIIWVN YLLSNPEYKD TPMDIAQLPH
LPEKTSESSE TSDSESDSKD TSGITEDNEN SKSDEKGNQS ENSEDPEPDR KKSGNACDND
MNCNDDGHSS SNPDSRDSDD SFEHSDFENP KAAEDGFGAL GPMHIKVERY VESESDLRLQ
NCESLTSDSA KDSDSAGEAG AQASSKHQKR KKRRKRQKGG SASRRRLSSA SSPGGLDAGL
VEPPRLLSSP HSASVLKIKT EISEPINFDN DSSIWNYPPN REICRNESPY SMTKPPSSEH
FPSPPGGGGG GGGGGGGLHV AIPDSVLTPP GADGAAARKT QFGASAAAAL APVASDPLSP
PLSASPRDKH PGGGGGGGGS GGGGSSGGSG GGPSASNSLL YTGDLEALQR LQAGNVVLPL
VHRVTGTLAA TSTAAQRVYT TGTIRYAPAE VTLAMQGNLL PNAHAVNFVD VNSPGFGLDP
KTPVEMLYHH VHRLNMSGPF GGAGGAASLT QMPGGNVFTT AEGLFSTLPF PVYSNGIHAA
QTLERKED
//
