ID G1SZQ5_RABIT Unreviewed; 964 AA.
AC G1SZQ5;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=Integrator complex subunit 4 {ECO:0000313|Ensembl:ENSOCUP00000009172.2};
GN Name=INTS4 {ECO:0000313|Ensembl:ENSOCUP00000009172.2};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000009172.2, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000009172.2, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000009172.2,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000009172.2}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000009172.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; AAGW02008308; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02008309; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_002708718.1; XM_002708672.3.
DR AlphaFoldDB; G1SZQ5; -.
DR SMR; G1SZQ5; -.
DR STRING; 9986.ENSOCUP00000009172; -.
DR PaxDb; 9986-ENSOCUP00000009172; -.
DR Ensembl; ENSOCUT00000010645.3; ENSOCUP00000009172.2; ENSOCUG00000010638.3.
DR GeneID; 100350308; -.
DR KEGG; ocu:100350308; -.
DR CTD; 92105; -.
DR eggNOG; KOG2259; Eukaryota.
DR GeneTree; ENSGT00390000010128; -.
DR HOGENOM; CLU_012910_1_0_1; -.
DR InParanoid; G1SZQ5; -.
DR OMA; GNRHPDY; -.
DR OrthoDB; 2903757at2759; -.
DR TreeFam; TF315047; -.
DR Proteomes; UP000001811; Chromosome 1.
DR Bgee; ENSOCUG00000010638; Expressed in testis and 14 other cell types or tissues.
DR GO; GO:0032039; C:integrator complex; IEA:Ensembl.
DR GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR GO; GO:0016180; P:snRNA processing; IEA:Ensembl.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 3.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR PANTHER; PTHR20938:SF0; INTEGRATOR COMPLEX SUBUNIT 4; 1.
DR PANTHER; PTHR20938; UNCHARACTERIZED; 1.
DR Pfam; PF13646; HEAT_2; 1.
DR Pfam; PF20168; PDS5; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
PE 4: Predicted;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811}.
SQ SEQUENCE 964 AA; 108391 MW; F01510E39606866C CRC64;
MAAHLKKRVY EEFTKVVQQQ QEEIATKKLR LTKPSKSAAL HIDLCKATSP ADALQYLLQF
ARKPVEAESV EGVVRILLEH YYKENDPSVR LKIASLLGLL SKTTGFSPDC IMDDAINILQ
NEKSHQVLAQ LLDTLLAIGT KLPENQAVQM RLVDVACKHL TDTSHGVRNK CLQLLGNLGS
LEKNVIKDAE GLTARDVQKI IGDYFSDQDP RVRTAAIKAM LQLHERGLKL HQTIYNQACK
LLSDDYEQVR SAAVQLIWVV SQLYPESIVP IPSSNEEIRL VDDAFGKICH MVSDGSWVVR
VQAAKLLGSM EQVSSHFLEQ TLDKKLMSDL RRKRTAHERA KELYSSGEFS SGRKWGDDAP
KEEIDTGAVN LIESGACGAF VHGLEDEMYE VRIAAVEALC MLAQSSPSFA EKCLDFLVDM
FNDEIEEVRL QSIHTMRKIS NNITLREDQL DTVLAVLEDS SRDIREALHE LLCCTNVSTK
EGIHLALVEL LKNLTKYPTD RDSIWKCLKF LGSRHPTLVL PLVPELLSTH PFFDTAEPDM
DDPAYIAVLV LIFNAAKTCP TMPALFSDHT FRHYAYLRDS LSHLVPALRL PGRKVLSSAI
SPSITPHEDP SQQFLQESLE RVYSLQHLDP QGAQELLEFT IRDLQRLGEL QSELAGVADF
SATYLRCQLL LIKALQEKLW NVAAPLYLKQ SDLASAAAKQ IMEETYKMEF MYSGVENKQV
VIIHHMRLQA KALQLIVTAR TTRGVDPLFG MCEKFLQEVD FFQRCFIADL PHLQDSFVDK
LLDLMPRLMT SKPAEVVKIL QNMLRQSTFL HLPLPEQIHK ASATIIEPAG ESDNPLRFTS
GLVVALDVDA TLEHVQDPQS TVKVQVLYPD GQAQMIHPKP ADFRNPGPGR HRLITQVYLS
HTAWTEPCQV EVRLLLAYNS SARIPKSPWM EGGEMAPQLE TSIEGTIPFS KPVKVYIMPK
PARR
//
