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Database: UniProt
Entry: G1SZX4_RABIT
LinkDB: G1SZX4_RABIT
Original site: G1SZX4_RABIT 
ID   G1SZX4_RABIT            Unreviewed;      2648 AA.
AC   G1SZX4;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   13-NOV-2013, sequence version 2.
DT   16-JAN-2019, entry version 48.
DE   SubName: Full=Inositol 1,4,5-trisphosphate receptor type 2 {ECO:0000313|Ensembl:ENSOCUP00000009262};
GN   Name=ITPR2 {ECO:0000313|Ensembl:ENSOCUP00000009262};
OS   Oryctolagus cuniculus (Rabbit).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae;
OC   Oryctolagus.
OX   NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000009262, ECO:0000313|Proteomes:UP000001811};
RN   [1] {ECO:0000313|Ensembl:ENSOCUP00000009262, ECO:0000313|Proteomes:UP000001811}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Thorbecke {ECO:0000313|Proteomes:UP000001811};
RX   PubMed=21993624; DOI=10.1038/nature10530;
RA   Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J.,
RA   Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E.,
RA   Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J.,
RA   Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S.,
RA   Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I.,
RA   Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I.,
RA   Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J.,
RA   Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D.,
RA   Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L.,
RA   Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S.,
RA   Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G.,
RA   Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K.,
RA   Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T.,
RA   Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J.,
RA   Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S.,
RA   Pedersen J.S., Lander E.S., Kellis M.;
RT   "A high-resolution map of human evolutionary constraint using 29
RT   mammals.";
RL   Nature 478:476-482(2011).
RN   [2] {ECO:0000313|Ensembl:ENSOCUP00000009262}
RP   IDENTIFICATION.
RC   STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000009262};
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
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DR   EMBL; AAGW02045024; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAGW02045025; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAGW02045026; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAGW02045027; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAGW02045028; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAGW02045029; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAGW02045030; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAGW02045031; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9986.ENSOCUP00000009262; -.
DR   Ensembl; ENSOCUT00000010759; ENSOCUP00000009262; ENSOCUG00000010741.
DR   eggNOG; KOG3533; Eukaryota.
DR   eggNOG; ENOG410XR97; LUCA.
DR   GeneTree; ENSGT00940000156039; -.
DR   InParanoid; G1SZX4; -.
DR   OMA; ENQVKGG; -.
DR   TreeFam; TF312815; -.
DR   Proteomes; UP000001811; Chromosome 8.
DR   Bgee; ENSOCUG00000010741; Expressed in 3 organ(s), highest expression level in liver.
DR   GO; GO:0005938; C:cell cortex; IEA:Ensembl.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR   GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR   GO; GO:0043235; C:receptor complex; IEA:Ensembl.
DR   GO; GO:0033017; C:sarcoplasmic reticulum membrane; IEA:Ensembl.
DR   GO; GO:0070679; F:inositol 1,4,5 trisphosphate binding; IEA:InterPro.
DR   GO; GO:0005220; F:inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; IEA:Ensembl.
DR   GO; GO:0035091; F:phosphatidylinositol binding; IEA:Ensembl.
DR   GO; GO:0097110; F:scaffold protein binding; IEA:Ensembl.
DR   GO; GO:0071320; P:cellular response to cAMP; IEA:Ensembl.
DR   GO; GO:0071361; P:cellular response to ethanol; IEA:Ensembl.
DR   GO; GO:0001666; P:response to hypoxia; IEA:Ensembl.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR000493; InsP3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   PRINTS; PR00779; INSP3RECEPTR.
DR   SMART; SM00472; MIR; 4.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001811};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2175   2197       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2209   2228       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2249   2273       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2293   2321       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2342   2364       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2469   2492       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       59    113       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      120    170       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      178    234       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      241    319       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      325    381       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   COILED       36     56       {ECO:0000256|SAM:Coils}.
FT   COILED     1543   1563       {ECO:0000256|SAM:Coils}.
FT   COILED     1869   1889       {ECO:0000256|SAM:Coils}.
FT   COILED     2593   2627       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2648 AA;  302162 MW;  91FC88808F1521A2 CRC64;
     MYCLFKVCPM NRYSAQKQYW KAKQAKQGNH TEAALLKKLQ HAAELEQKQN ESENKKLLGE
     IVKYSNVIQL LHIKSNKYLT VNKRLPALLE KNAMRVSLDA AGNEGSWFYI HPFWKLRSEG
     DNIVVGDKVV LMPVNAGQPL HASNIELLDN PGCKEVNAVN CNTSWKITLF MKFSSYREDV
     LKGGDVVRLF HAEQEKFLTC DEYEKKQHIF LRTTLRQSAT SATSSKALWE IEVVHHDPCR
     GGAGQWNSLF RFKHLATGNY LAAELNPDYR DAQSEGKNAR EGDLPTSKKK RQVGEKIMYT
     LVSVPHGNDI ASLFELDATT LQRADCLVPR NSYVRLRHLC TNTWVTSTSI PIDTDEERPV
     MLKIGTCQTK EDKEAFAIVS VPLSEVRDLD FANDANKVLA TTVKKLENGT ITQNERRFVT
     KLLEDLIFFV ADVPNNGQEV LDVVITKPNR ERQKLMREQN ILAQVFGILK APFKEKAGEG
     SMLRLEDLGD QRYAPYKYML RLCYRVLRHS QQDYRKNQEY IAKNFCVMQS QIGYDILAED
     TITALLHNNR KLLEKHITAK EIETFVSLLR RNREPRFLDY LSDLCVSNTT AIPVTQELIC
     KFMLSPGNAD ILIQTKLVSM QIDNPMESSI LPDDIDDEEV WLYWIDSNKE PHGKAIRHLA
     QEAKEGTKAD LEVLTYYRYQ LNLFARMCLD RQYLAINQIS TQLSVDLILR CVSDESLPFD
     LRASFCRLML HMHVDRDPQE SVVPVRYARL WTEIPTKITI HEYDSITDSS RNDMKRKFAL
     TMEFVEEYLK EVVNQPFPFG DKEKNKLTFE VVHLARNLIY FGFYSFSELL RLTRTLLAIL
     DIVQAPMSSY FERLSKFQDG GNNVMRTIHG VGEMMTQMVL SRGSIFPMSV PDTQPSVHPS
     KQASPTEQED VTVMDTKLKI IEILQFILSV RLDYRISYML SIYKKEFGEN SENAEVSATG
     SPETLLPSAL VPDIEEIAAQ AETMFAGRKE KNPVQLDDEG GRTFLRVLIH LIMHEYPPLL
     SGALQLLFKH FSQRAEVLQA FRQVQLLVSN QDVDNYKQIK ADLDQLRLTV EKSELWVEKS
     SSYESGEAGE SQVKGGEEPM EESNILSPVQ DGTKKPQIDS NKRNNYRVVK EILIRLSKLC
     VQNKKCRNQH QRLLKNMGAH SVVLDLLQIP YEKNDEKMNE VMTLAHTFLQ NFCRGNPQNQ
     VLLHKHLHLF LTPGLLEAET MRHIFMNNYH LCNEISERVV QHFVHCIETH GRHVEYLRFL
     QTIVKADGKY VKKCQDMVMT ELINGGEDVL IFYNDRASFP SLLHMMCSER DRGDDSGPLA
     YHITLVELLA ACTEGKNVYT EIKCNSLLPL DDIVRVVTHD DCIPEVKIAY VNFVNHCYVD
     TEVEMKEIYT SNHIWKLFEN FLVDMARVCN TTTDRKHADT FLEKCVTESI MSIVSGFFNS
     PFSDSSTSLQ THQPVFIQLL QSAFRIYNCT WPNPAQKASV ESCIRTLAEV AKNRGIAIPV
     DLDSQVNTLF MKSHSNMVQR AAMGWRLSAR SGPRFKEALG GPAWDYRNII EKLQDVVASL
     EQQLSPMMQA EFSVLVDVLY SPELLFPEGS DARIRCGAFM SKLINHTKKL MEKEEKLCIK
     ILKTLREMLE KKDSFVEEGN TLRKILLNRY FKGDYGIGMN GHLSGTYSRS AQVGGSFSAQ
     DTDKMGISMA DIQCLLDKEG ASELVIDVIV NTKNDRIFSE GILLGIALLE GGNTQTQYSF
     YQQLHEQKKS EKFFKVLYDR MKAAQKEIRS TVTVNTIDLG SKKRDDDNEA MTSGPRMRVR
     DSSLHLKEGM KGQLTEASSA TSKAYCVYRR EMDPELDMVC SGPEAGSAED RSAEEVPMSP
     AIAIMQPILR FLQLLCENHN RELQNFLRNQ NNKTNYNLVC ETLQFLDCIC GSTTGGLGLL
     GLYINEKNVA LVNQTLESLT EYCQGPCHEN QTCIATHESN GIDIIIALIL NDINPLGKYR
     MDLVLQLKNN ASKLLLAIME SRHDSENAER ILFNMRPREL VDVMKNAYNQ GVECDRGDDE
     GGDDGVSPKD VGHNIYILAH QLARHNKLLQ HMLKPGLDPE EGDEALKYYA NHTAQIEIVR
     HDRTMEQIVF PVPNICEYLT RESKCRVYNT TERDEQGSKV NDFFQQTEDL YNEMKWQKKI
     RSNPALFWFS RHISLWGSIS FNLAVFINLA VALFYPFGDD GDEGTLSPLF SILLWIAVAI
     CTSMLFFFSK PVGIRPFLVS IMLRSIYTIG LGPTLILLGA ANLCNKIVFL VSFVGNRGTF
     TRGYRAVILD VAFLYHVAYV LVCMLGLFIH EFFYSFLLFD LVYREETLLN VIKSVTRNGR
     SIILTAVLAL ILVYLFSIIG FLFLKDDFTM EVDRLKNRTP VTGNYEVPTT TLSSMTETCD
     KNNCSATIPA SSTAGEEYED GIERTCDTLL MCIVTVLNQG LRNGGGVGDV LRRPSKDEPL
     FAARVVYDLL FFFIVIIIVL NLIFGVIIDT FADLRSEKQK KEEILKTTCF ICGLERDKFD
     NKTVSFEEHI KSEHNMWHYL YFIVLVKVKD PTEYTGPESY VAQMIVEKNL DWFPRMRAMS
     LVSNEGDSEQ NEIRSLQEKL ESTMSLVRQL SGQLAELKEQ MTEQRKNKQR LGFLGSNTAH
     VNHHMPPH
//
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