ID G1T082_RABIT Unreviewed; 1176 AA.
AC G1T082;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=Insulin receptor substrate 4 {ECO:0000313|Ensembl:ENSOCUP00000009383.3};
GN Name=IRS4 {ECO:0000313|Ensembl:ENSOCUP00000009383.3};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000009383.3, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000009383.3, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000009383.3,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000009383.3}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000009383.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAGW02041305; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02041306; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1T082; -.
DR SMR; G1T082; -.
DR STRING; 9986.ENSOCUP00000009383; -.
DR PaxDb; 9986-ENSOCUP00000009383; -.
DR Ensembl; ENSOCUT00000010905.3; ENSOCUP00000009383.3; ENSOCUG00000010909.3.
DR eggNOG; ENOG502SD84; Eukaryota.
DR GeneTree; ENSGT00940000160883; -.
DR HOGENOM; CLU_290952_0_0_1; -.
DR InParanoid; G1T082; -.
DR TreeFam; TF325994; -.
DR Proteomes; UP000001811; Chromosome X.
DR Bgee; ENSOCUG00000010909; Expressed in embryo.
DR GO; GO:0005158; F:insulin receptor binding; IEA:InterPro.
DR GO; GO:0008286; P:insulin receptor signaling pathway; IEA:InterPro.
DR CDD; cd01204; PTB_IRS; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR InterPro; IPR039011; IRS.
DR InterPro; IPR002404; IRS_PTB.
DR InterPro; IPR011993; PH-like_dom_sf.
DR PANTHER; PTHR10614; INSULIN RECEPTOR SUBSTRATE; 1.
DR PANTHER; PTHR10614:SF2; INSULIN RECEPTOR SUBSTRATE 4; 1.
DR Pfam; PF02174; IRS; 1.
DR PRINTS; PR00628; INSULINRSI.
DR SMART; SM01244; IRS; 1.
DR SMART; SM00310; PTBI; 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR PROSITE; PS51064; IRS_PTB; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001811}.
FT DOMAIN 145..249
FT /note="IRS-type PTB"
FT /evidence="ECO:0000259|PROSITE:PS51064"
FT REGION 354..569
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 588..611
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 646..835
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1107..1154
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 376..396
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 410..474
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 507..535
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 547..563
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 716..746
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1139..1154
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1176 AA; 125161 MW; 13F6B1D5D09787FF CRC64;
TERDLPPTCL LIPKMTADAP ARLEYYENAR KFRHSVRAAA AAAAAAASGA AVPALIPPRR
VITLYQCFSV SQRADARYRH LIALFTQDEY FAMVAENESE QESWYLLLSR LILDSKRRRC
GTLGALADRE PAARAAAAAA EPPFYRDVWQ VVVKPRGLGH RKELSGVFRL CLTDEEVVFV
RLNTEVASVV VQLLSIRRCG HSEQYFFLEV GRSTVIGPGE LWMQVDDCVV AQNMHELFLE
KMRALSADDY RARCRSYSIS IGAHLLTLLS ARRHLGLLPL EPGGWLRRSR TEQFCHLRAI
GDGEDEMLVT RRFVTPSEPV PPCRRGRLYL PRARRSRRAI SMPARFFRRL PASQVRAPHR
EAAASDRACL SAEAAGSGSG SGNSAEEGNP QSKEGQEGSG DDYMPMNSRG SGNGRGSGGG
HGSSGQGSSS RTSGGNQCSG GEQGSGGGQG SSRRQGSGGG QGSGGNQCSR DGRGTTGGHG
SGGGPGPGGG QGSGGGQGPG DGHGWGRGKN SEGDKGSGRG KGSNGDGDRG KSLKKRSYFG
KLTQSKQMPP PPAPPPPPPP AAGAAVGKGK SGGRFRLYFC ADRGATKERK EAKELKDLET
PEGAARGLHR ARAFDEDEDY AYMPMRPGVA ASLASSNDYM PMAPQNVSAS LKRHSRPPFE
DARGYMMMFP RESPPPAPSP PKAADPNKEG DSKDDGDSDY MFMAPGAGAI PKNPKNPQGG
ASSKSWSSYF SLPNPFRSSS LGQSDHSEYV PMLPGKFLGR GSDKEVSSNW GPQDTGPKPS
VEGSHSKPRN GGAPLKPSDD GPPKNKAKRP NRLSLMIKGN TMKPKLQKPR SEQRQADYVN
ADFSERVRNM PAPSTEGLPG SWGAIANPRH SLFSSYLNVE FGVPFPNPAN TLSDLFLRAM
PGANPFSLDG ARWPLPLLPL RATGSNANGD EGDCIKVIFN PAMTPAVPFA DSAIRYDAET
GRIYVVDPFS ECCMDISRSP SRCSDPPPVA RLLQEEEHGR RHPPSRSQTF FAAARTAVSA
FPTDSLDRDL SASSAPAAAW AAAPTLAVGR ALAAASALAA APGIGAAAAS FEAAAGFDSA
SARWFQPVVA AAAAAAALSG VQDIAGGSSP GAPNPPADLV RGENGAGRAA TPPRPLRRRW
VRRPPEREDS DSDNFYLRMG LVKPDYKKFN SPKRGW
//
