ID G1T083_RABIT Unreviewed; 553 AA.
AC G1T083;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=Shisa family member 6 {ECO:0000313|Ensembl:ENSOCUP00000009384.2};
GN Name=SHISA6 {ECO:0000313|Ensembl:ENSOCUP00000009384.2};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000009384.2, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000009384.2, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000009384.2,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000009384.2}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000009384.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAGW02049447; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02049448; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02049449; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02049450; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02049451; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02049452; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02049453; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02049454; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_008268938.1; XM_008270716.2.
DR AlphaFoldDB; G1T083; -.
DR PaxDb; 9986-ENSOCUP00000009384; -.
DR Ensembl; ENSOCUT00000010906.4; ENSOCUP00000009384.2; ENSOCUG00000010908.4.
DR eggNOG; ENOG502QUEF; Eukaryota.
DR GeneTree; ENSGT00940000156854; -.
DR HOGENOM; CLU_025677_1_0_1; -.
DR InParanoid; G1T083; -.
DR OMA; FECNNTN; -.
DR OrthoDB; 4086546at2759; -.
DR TreeFam; TF330800; -.
DR Proteomes; UP000001811; Chromosome 19.
DR Bgee; ENSOCUG00000010908; Expressed in prefrontal cortex and 6 other cell types or tissues.
DR GO; GO:0032281; C:AMPA glutamate receptor complex; IEA:Ensembl.
DR GO; GO:0098985; C:asymmetric, glutamatergic, excitatory synapse; IEA:Ensembl.
DR GO; GO:0098839; C:postsynaptic density membrane; IEA:Ensembl.
DR GO; GO:0035255; F:ionotropic glutamate receptor binding; IEA:Ensembl.
DR GO; GO:0030165; F:PDZ domain binding; IEA:Ensembl.
DR GO; GO:0098976; P:excitatory chemical synaptic transmission; IEA:Ensembl.
DR GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IEA:Ensembl.
DR GO; GO:0098970; P:postsynaptic neurotransmitter receptor diffusion trapping; IEA:Ensembl.
DR GO; GO:1904717; P:regulation of AMPA glutamate receptor clustering; IEA:Ensembl.
DR GO; GO:0007283; P:spermatogenesis; IEA:Ensembl.
DR InterPro; IPR026910; Shisa.
DR PANTHER; PTHR31774:SF0; PROTEIN SHISA-6; 1.
DR PANTHER; PTHR31774; PROTEIN SHISA-9-RELATED; 1.
DR Pfam; PF13908; Shisa; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 28..553
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003423257"
FT TRANSMEM 178..201
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 42..79
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 243..271
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 497..523
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 243..261
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 498..520
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 553 AA; 61183 MW; CB37D783727A2EBB CRC64;
MALRRLLLML LLLLSLESLD LLPGAHAARG RATNRTLSAG AAAVGGRRPG GALARGGREL
NGTARGASGG PEAGSKGGQP AAAVAAASAT VTCETCWGYY DVSGQYDKEF ECNNSESGYL
YCCGTCYYRF CCKTRHEKLD QRQCTNYQSP VWVQTPSTKV VSPGPENKYD PEKDKTNFTV
YITCGVIAFV VVAGVFAKIS YDKAHRPPRE MNIHRALADI LRQQGPIPIA HCEREAISAI
DTSPKENTPV RSSSKNLYTP VRTAKPTPGH YGKDAYRSGG PDLHNFISSG FVTLGRGHTK
GDHQYNHPIL SSATQTPTHE KPRMNNILTS ATEPYDLSFS RSFQNLAHLP PSYESAVKTN
PSKYSSLKRL TDKEADEYYM RRRHLPDLAA RGTLPLNVIQ MSQQKPLPRE RPRRPIRAMS
QDRVLSPQRG LPDEFGMPYD RILSDEQLLS TERLHSQDPL LSPERTAFPE QSLSRAISHT
DVFVSTPVLD RYRMTKMHSH PSASNNSYAT LGQSQTAAKR HAFASRRHNT VEQLHYIPGH
HTCYTASKTE VTV
//
