ID G1T0S2_RABIT Unreviewed; 657 AA.
AC G1T0S2;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 58.
DE RecName: Full=Holliday junction recognition protein {ECO:0008006|Google:ProtNLM};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000009609.4, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000009609.4, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke {ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000009609.4}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000009609.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; G1T0S2; -.
DR STRING; 9986.ENSOCUP00000009609; -.
DR PaxDb; 9986-ENSOCUP00000009609; -.
DR Ensembl; ENSOCUT00000011171.4; ENSOCUP00000009609.4; ENSOCUG00000011170.4.
DR eggNOG; ENOG502SJZT; Eukaryota.
DR GeneTree; ENSGT00390000005575; -.
DR HOGENOM; CLU_408789_0_0_1; -.
DR InParanoid; G1T0S2; -.
DR TreeFam; TF336293; -.
DR Proteomes; UP000001811; Unplaced.
DR Bgee; ENSOCUG00000011170; Expressed in autopod skin and 11 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR InterPro; IPR022102; HJURP_C.
DR InterPro; IPR021052; HJURP_central_dom.
DR PANTHER; PTHR15992; HOLLIDAY JUNCTION RECOGNITION PROTEIN; 1.
DR PANTHER; PTHR15992:SF5; HOLLIDAY JUNCTION RECOGNITION PROTEIN; 1.
DR Pfam; PF12347; HJURP_C; 2.
DR Pfam; PF12346; HJURP_mid; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811}.
FT DOMAIN 221..335
FT /note="Holliday junction recognition protein HJURP central"
FT /evidence="ECO:0000259|Pfam:PF12346"
FT DOMAIN 359..420
FT /note="Holliday junction regulator protein family C-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF12347"
FT DOMAIN 501..548
FT /note="Holliday junction regulator protein family C-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF12347"
FT REGION 36..92
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 136..190
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 262..289
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 453..521
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 542..657
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 36..62
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 170..190
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 468..482
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 634..657
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 657 AA; 70721 MW; 9B8ED1DC3D322F10 CRC64;
MLMAQTIQLL VLQRHSPSGR ACAGRRMWGG RLIQEGSEAQ AQQVRRSDGP LQTASQGHEV
SLDSTRGPEA GSKGSDVDAS PEREAAAARA VVPAAPQGPL EVELRRKYLT QVDILLQDAE
FFERAALRDG KDTYKTLARP ATPAPGCRGG VSGSSPGGPA KPASPPQEQC PLHPGSTDTG
TEHQDDSLCS LGTDGSGRSW AAEELCDVTI SELYAGMLRS MSRLLSAKPA CVISTRASVL
QAWSCRRRHR WRSRLNRTYC EAGRRSRGSS SHPPLPGPEP EPGAGPLRDC KNLLDVSRRK
AGFKLERACL EGNKSQVQTS DPGWKELQLT PRRNSAPAGS DVGAVRALGR ERRLGMLQWL
LSPVKLISGP ATPQGPRRER YREIRVRFER LHREYALSPG RQPRHTGLAD SWAVGLYSGG
PVSPGGSWSF ETHRPGLSVR AKGKTLREAF ERLGRSVDSG QGRPEDGPSP LPAGPSPVPS
PGRPQQARSL VPGSSPGLLR KAASPGGAVP GPRTEPLGCG RNRYDEIKEE FDKLHREYCS
TAPRPVAASP DTASAQARHR TDDVLGKPNP DSRSQKLSLS AQWHRKGALG SSAVEDGVSA
GATRGDHWSP AKRRRLPDPQ LRAPQADSWD SPGPDHPAGK RRGESAAFQT DGRSDCR
//
