ID G1T155_RABIT Unreviewed; 844 AA.
AC G1T155;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 72.
DE RecName: Full=Spondin-1 {ECO:0000256|ARBA:ARBA00019594};
DE AltName: Full=F-spondin {ECO:0000256|ARBA:ARBA00030964};
GN Name=SPON1 {ECO:0000313|Ensembl:ENSOCUP00000009769.3};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000009769.3, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000009769.3, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000009769.3,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000009769.3}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000009769.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498}.
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DR EMBL; AAGW02007763; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02007764; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02007765; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02007766; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02007767; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02007768; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02007769; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02007770; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02007771; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02007772; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1T155; -.
DR SMR; G1T155; -.
DR STRING; 9986.ENSOCUP00000009769; -.
DR Ensembl; ENSOCUT00000011352.4; ENSOCUP00000009769.3; ENSOCUG00000011350.4.
DR eggNOG; KOG3539; Eukaryota.
DR GeneTree; ENSGT00940000154910; -.
DR HOGENOM; CLU_014540_1_0_1; -.
DR InParanoid; G1T155; -.
DR TreeFam; TF313353; -.
DR Proteomes; UP000001811; Chromosome 1.
DR Bgee; ENSOCUG00000011350; Expressed in left lung and 17 other cell types or tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0050693; F:LBD domain binding; IEA:Ensembl.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:1902430; P:negative regulation of amyloid-beta formation; IEA:Ensembl.
DR GO; GO:1902993; P:positive regulation of amyloid precursor protein catabolic process; IEA:Ensembl.
DR GO; GO:0010954; P:positive regulation of protein processing; IEA:Ensembl.
DR GO; GO:0016485; P:protein processing; IEA:Ensembl.
DR CDD; cd08544; Reeler; 1.
DR Gene3D; 2.60.40.2130; F-spondin domain; 1.
DR Gene3D; 2.60.40.4060; Reeler domain; 1.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 6.
DR InterPro; IPR002861; Reeler_dom.
DR InterPro; IPR042307; Reeler_sf.
DR InterPro; IPR009465; Spondin_N.
DR InterPro; IPR038678; Spondin_N_sf.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR InterPro; IPR044004; TSP1_spondin_dom.
DR NCBIfam; NF038123; NF038123_dom; 1.
DR PANTHER; PTHR11311; SPONDIN; 1.
DR PANTHER; PTHR11311:SF16; SPONDIN-1; 1.
DR Pfam; PF02014; Reeler; 1.
DR Pfam; PF06468; Spond_N; 1.
DR Pfam; PF19028; TSP1_spondin; 1.
DR Pfam; PF00090; TSP_1; 5.
DR SMART; SM00209; TSP1; 6.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 6.
DR PROSITE; PS51019; REELIN; 1.
DR PROSITE; PS51020; SPONDIN; 1.
DR PROSITE; PS50092; TSP1; 6.
PE 4: Predicted;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..28
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 29..844
FT /note="Spondin-1"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5023863131"
FT DOMAIN 29..194
FT /note="Reelin"
FT /evidence="ECO:0000259|PROSITE:PS51019"
FT DOMAIN 195..388
FT /note="Spondin"
FT /evidence="ECO:0000259|PROSITE:PS51020"
SQ SEQUENCE 844 AA; 95334 MW; ECA5337FB4805533 CRC64;
MRLSPAPLRL SRTLALLALA LPLAAALAFS DETLDKVAKS EGYCSRILRA QGTRREGYTE
FSLRVEGDPD FYKPGTSYRV TLSAAPPSYF RGFTLIALKE NREGDKEEDH AGTFQIIDEE
ETQFMSNCPV AVTESTPRRR TRIQVFWIAP PTGTGCVILK ASIVQKRIIY FQDEGSLTKK
LCEQDSTFDG VTDKPILDCC ACGTAKYRLT FYGNWSEKTH PKDYPRRANH WSAIIGGSHS
KNYVLWEYGG YASEGVKQVA ELGSPVKMEE EIRQQSDEVL TVIKAKAQWP AWQPLNVRAA
PSAEFSVDRT RHLMSFLTMM GPSPDWNVGL SAEDLCTKEC GWVQKVVQDL IPWDAGTDSG
VTYESPNKPT IPQEKIRPLT SLDHPQSPFY DPEGGSIIQV ARVVIERIAR KGEQCNIVPD
NVDDIVADLA PEEKDEDDTP ETCIYSNWSP WSACSSSTCD KGKRMRQRML KAQLDLSVPC
PDTQDFQPCM GPGCSDEDGS TCTMSEWITW SPCSISCGTG MRSRERYVKQ FPEDGSVCTL
PTEETEKCTV NEECSPSSCL MTEWGEWDEC SATCGMGMKK RHRMVKMSPA DGSMCKAETS
QTEKCMMPEC HTIPCLLSPW SEWSDCSVTC GKGMRTRQRM LKSLAELGDC NEELEQVEKC
MLPECPIDCE LTEWSQWSEC NKSCGKGHMI RTRMIQMEPQ FGGAPCPETV QRKKCRVRKC
LRNPSIQKLR WREARESRRG EQLREESDGE QFPGCRMRPW TAWSECTKLC GGGIQERYMT
VKKSWCSPRN PARKSFRNAD FRKHYKHQPA FHQVHLPNDQ GRLLDSNPKA LLRKAINLQK
LSFS
//
