ID G1T1D1_RABIT Unreviewed; 312 AA.
AC G1T1D1;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 60.
DE SubName: Full=Torsin family 3 member A {ECO:0000313|Ensembl:ENSOCUP00000009867.3};
GN Name=TOR3A {ECO:0000313|Ensembl:ENSOCUP00000009867.3};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000009867.3, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000009867.3, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000009867.3,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000009867.3}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000009867.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum lumen
CC {ECO:0000256|ARBA:ARBA00004319}.
CC -!- SIMILARITY: Belongs to the ClpA/ClpB family. Torsin subfamily.
CC {ECO:0000256|ARBA:ARBA00006235}.
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DR EMBL; AAGW02056656; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02056657; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02056658; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1T1D1; -.
DR SMR; G1T1D1; -.
DR STRING; 9986.ENSOCUP00000009867; -.
DR PaxDb; 9986-ENSOCUP00000009867; -.
DR Ensembl; ENSOCUT00000011472.3; ENSOCUP00000009867.3; ENSOCUG00000011475.3.
DR eggNOG; KOG2170; Eukaryota.
DR GeneTree; ENSGT00950000182888; -.
DR HOGENOM; CLU_053537_0_0_1; -.
DR InParanoid; G1T1D1; -.
DR TreeFam; TF314941; -.
DR Proteomes; UP000001811; Chromosome 13.
DR Bgee; ENSOCUG00000011475; Expressed in uterus and 19 other cell types or tissues.
DR GO; GO:0005788; C:endoplasmic reticulum lumen; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:Ensembl.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR049337; TOR1A_C.
DR InterPro; IPR010448; Torsin.
DR PANTHER; PTHR10760; TORSIN; 1.
DR PANTHER; PTHR10760:SF3; TORSIN-3A; 1.
DR Pfam; PF21376; TOR1A_C; 1.
DR Pfam; PF06309; Torsin; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000001811}.
FT DOMAIN 253..310
FT /note="Torsin-1A C-terminal"
FT /evidence="ECO:0000259|Pfam:PF21376"
SQ SEQUENCE 312 AA; 34383 MW; 7D33F5345630A4F3 CRC64;
MACHCEASQG EQLTPLEVSR GAGGRGCRGC GSRGLLSPPP GLDSDLSGRL HGQHLARELV
LRTVKGYLEV PRPDKALALS FHGWSGTGKN FVARMLAENL YRDGQRSACV RMLIATIHFP
HPKYVDLYKE QLMAQIRETQ QRCRQTLFIF DEAEKLHPEL AGLVPVLSVR LGEAQFKAEL
TGASLSLSNL GGNVINELVL EWLQAGRARE EITAEQLEPQ LRAEVAASTD SGFGASRLVK
ENLIDAFVPF LPLEFGHVRL CARDAFLSQG LAYTEEALDS IARLMVYVPK EGQRFSAQGC
KSVSQRIHYF LP
//
