ID G1T2U7_RABIT Unreviewed; 653 AA.
AC G1T2U7;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 78.
DE SubName: Full=Dynein cytoplasmic 1 intermediate chain 1 {ECO:0000313|Ensembl:ENSOCUP00000010512.4};
GN Name=DYNC1I1 {ECO:0000313|Ensembl:ENSOCUP00000010512.4};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000010512.4, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000010512.4, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000010512.4,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000010512.4}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000010512.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the dynein intermediate chain family.
CC {ECO:0000256|ARBA:ARBA00011059}.
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DR EMBL; AAGW02035448; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02035449; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02035450; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02035451; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02035452; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02035453; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02035454; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02035455; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1T2U7; -.
DR SMR; G1T2U7; -.
DR STRING; 9986.ENSOCUP00000010512; -.
DR PaxDb; 9986-ENSOCUP00000010512; -.
DR Ensembl; ENSOCUT00000012213.4; ENSOCUP00000010512.4; ENSOCUG00000012213.4.
DR eggNOG; KOG1587; Eukaryota.
DR GeneTree; ENSGT00940000156032; -.
DR HOGENOM; CLU_012999_1_1_1; -.
DR InParanoid; G1T2U7; -.
DR TreeFam; TF300553; -.
DR Proteomes; UP000001811; Chromosome 10.
DR Bgee; ENSOCUG00000012213; Expressed in frontal cortex and 11 other cell types or tissues.
DR GO; GO:0005868; C:cytoplasmic dynein complex; IEA:InterPro.
DR GO; GO:0036464; C:cytoplasmic ribonucleoprotein granule; IEA:Ensembl.
DR GO; GO:0000776; C:kinetochore; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR GO; GO:0055037; C:recycling endosome; IEA:Ensembl.
DR GO; GO:0000922; C:spindle pole; IEA:Ensembl.
DR GO; GO:0030507; F:spectrin binding; IEA:Ensembl.
DR GO; GO:0047496; P:vesicle transport along microtubule; IEA:Ensembl.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR025956; DYNC1I1/DYNC1I2.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR12442:SF34; CYTOPLASMIC DYNEIN 1 INTERMEDIATE CHAIN 1; 1.
DR PANTHER; PTHR12442; DYNEIN INTERMEDIATE CHAIN; 1.
DR Pfam; PF11540; Dynein_IC2; 1.
DR Pfam; PF00400; WD40; 2.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
PE 3: Inferred from homology;
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574}.
FT REGION 19..139
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 177..229
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 26..86
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 105..139
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 198..229
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 653 AA; 73619 MW; 65EC35C40D8E9073 CRC64;
MHIIWTSHID ITKTTWTSTR NGETTMSDKS DLKAELERKK QRLAQIREEK KRKEEERKKK
EADLQQKKEP VQDDSDLDRK RRETEALLQS IGISPEPPLV PTPMSPSSKS VSTPSEAGSQ
DSGDLGPLTR TLQWDTDPSV LQLQSDSELG RRLHKLGVSK VTQVDFLPRE VVSYSKETQT
PLATHQSEED EEDEEMVEPK VGHDSELESQ DPKQEVKEAP PRELTEEEKQ QILHSEEFLI
FFDRTIRVIE RALAEDADIF FDYSGRELEE KDGDVQAGAN LSFNRQFYDE HWSKHRVVTC
MDWSLQYPEL MVASYNNNED APHEPDGVAL VWNMKFKKTT PEYVFHCQSS VMSVCFARFH
PNLVVGGTYS GQIVLWDNRS HRRTPVQRTP LSAAAHTHPV YCVNVVGTQN AHNLITVSTD
GKMCSWSLDM LSTPQESMEL VYNKSKSIAV TGMAFPTGDV NNFVVGSEEG TVYTACRHGS
KAGIGEVFEG HQGPVTGINC HMAVGPIDFS HLFVTSSFDW TVKLWTTKHN KPLYSFEDNA
DYVYDVMWSP VHPALFACVD GMGRLDLWNL NTDTEVPTAS VAIEGASALN RVRWAQAGKE
VAVGDSEGRI WIYDVGELAV PHNDEWTRFA RTLVEIRANR ADSEEEGAVE LTA
//
