ID G1T576_RABIT Unreviewed; 873 AA.
AC G1T576;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 2.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=Polyhomeotic homolog 2 {ECO:0000313|Ensembl:ENSOCUP00000011479.3};
GN Name=PHC2 {ECO:0000313|Ensembl:ENSOCUP00000011479.3};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000011479.3, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000011479.3, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke {ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000011479.3}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000011479.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR RefSeq; XP_008271946.1; XM_008273724.2.
DR AlphaFoldDB; G1T576; -.
DR SMR; G1T576; -.
DR STRING; 9986.ENSOCUP00000011479; -.
DR PaxDb; 9986-ENSOCUP00000011479; -.
DR Ensembl; ENSOCUT00000013337.4; ENSOCUP00000011479.3; ENSOCUG00000013332.4.
DR GeneID; 100351541; -.
DR KEGG; ocu:100351541; -.
DR CTD; 1912; -.
DR eggNOG; ENOG502QS5Q; Eukaryota.
DR GeneTree; ENSGT00940000160840; -.
DR HOGENOM; CLU_012048_0_0_1; -.
DR InParanoid; G1T576; -.
DR OMA; HSPAHET; -.
DR Proteomes; UP000001811; Unplaced.
DR Bgee; ENSOCUG00000013332; Expressed in uterus and 16 other cell types or tissues.
DR GO; GO:0000792; C:heterochromatin; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0035102; C:PRC1 complex; IEA:Ensembl.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0007283; P:spermatogenesis; IEA:Ensembl.
DR CDD; cd09577; SAM_Ph1_2_3; 1.
DR Gene3D; 3.30.60.160; -; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR012313; Znf_FCS.
DR InterPro; IPR038603; Znf_FCS_sf.
DR PANTHER; PTHR12247; POLYCOMB GROUP PROTEIN; 1.
DR PANTHER; PTHR12247:SF86; POLYHOMEOTIC-LIKE PROTEIN 2; 1.
DR Pfam; PF16616; PHC2_SAM_assoc; 1.
DR Pfam; PF00536; SAM_1; 1.
DR Pfam; PF21319; zf-FCS_1; 1.
DR SMART; SM00454; SAM; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
DR PROSITE; PS51024; ZF_FCS; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00367}.
FT DOMAIN 648..682
FT /note="FCS-type"
FT /evidence="ECO:0000259|PROSITE:PS51024"
FT DOMAIN 809..873
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT REGION 1..51
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 232..325
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 352..394
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 423..459
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 476..506
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 544..576
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 700..735
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 747..783
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 232..248
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 295..317
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 423..442
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 546..572
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 712..735
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 747..777
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 873 AA; 91381 MW; 833714E5B4702673 CRC64;
MENEPPAPHT SGSASVTSST SGSSSSNGGS GSSSGSSGGS GRATGPQISV YSGIPDRQTV
QVIQQALHRQ PSTAAQYLQQ MYAAQQQHLM LQTAALQQQH LSSAQLQSLA AVQQASLVAS
RQGSASGSSV SAQAPAQPSS INLAASPAAA QLINRAQSVN SATASGIAQQ AVLLGNTSAP
ALTASQAQMY LRAQMLIFTP TATVATVQPE LGTGAPARPP TPAQVQNLTL RTQQTPAAAS
SGPTPTQPVL PNLALKPSPG GSQPVPTPSQ GRNTAQGSPA GAKPGVMDSV TEPLKKGDGS
SSTSSSSSSS SSVPGSTEGR AGPGRAVPAV AAHPLIAPAY AQLQPHQILP QSSSKHLQPQ
FVTQQQQPSP PQQPQHSQQA RPVLQAQAQP QLASVPPSLA LQPSSEAHAV PLGPVTPTLP
LQCPTANLHK AGSSQQCHPP TADAGPQNGH PEGVSHTPQR RFQHASAVIL QLQPASPVPQ
QCAPDAWKDA APGEKSGPES RPGLSPHQQA IVTAVPGGLP VPKSPNVQQS PVHETGQGIV
HALTDLSSPG MTSGNGNSAS SIAGTAPQNG ENKPPQAIVK PQILTHVIEG FVIQEGAEPF
PVGRSSLLVG NLKKKYAQGF LPEKLPQQDH TTTTDSEMEE PYLQESKEEG TPLKLKCELC
GRVDFAYKFK RSKRFCSMAC AKRYNVGCTK RVGLFHSDRS KLQKAGTTAH SRRRASKASL
PTLTKDTKKQ PTGTVPLSVT AALQLTHSQE DSSRCSDNSS YEEPLSPISA SSSTSRRRQG
QRDLELPDMH MRDLVGMGHH FLPSEPTKWN VEDVYEFIRS LPGCQEIAEE FRAQEIDGQA
LLLLKEDHLM SAMNIKLGPA LKIYARISML KDS
//