ID G1T5V0_RABIT Unreviewed; 299 AA.
AC G1T5V0;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=Ciliogenesis and planar polarity effector 2 {ECO:0000256|ARBA:ARBA00021423};
DE AltName: Full=REM2- and Rab-like small GTPase 1 {ECO:0000256|ARBA:ARBA00030243};
GN Name=CPLANE2 {ECO:0000313|Ensembl:ENSOCUP00000011745.3};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000011745.3, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000011745.3, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke {ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000011745.3}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000011745.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Potential effector of the planar cell polarity signaling
CC pathway. Plays a role in targeted membrane trafficking most probably at
CC the level of vesicle fusion with membranes. Involved in cilium
CC biogenesis by regulating the transport of cargo proteins to the basal
CC body and to the apical tips of cilia. More generally involved in
CC exocytosis in secretory cells. {ECO:0000256|ARBA:ARBA00025052}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium basal body
CC {ECO:0000256|ARBA:ARBA00004120}.
CC -!- SIMILARITY: Belongs to the small GTPase superfamily. Rab family.
CC {ECO:0000256|ARBA:ARBA00006270}.
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DR RefSeq; XP_017193764.1; XM_017338275.1.
DR AlphaFoldDB; G1T5V0; -.
DR Ensembl; ENSOCUT00000013646.3; ENSOCUP00000011745.3; ENSOCUG00000013650.3.
DR GeneID; 100346503; -.
DR CTD; 79363; -.
DR eggNOG; KOG0395; Eukaryota.
DR GeneTree; ENSGT00390000006521; -.
DR HOGENOM; CLU_094613_0_0_1; -.
DR OrthoDB; 3667344at2759; -.
DR TreeFam; TF329319; -.
DR Proteomes; UP000001811; Unplaced.
DR Bgee; ENSOCUG00000013650; Expressed in uterus and 18 other cell types or tissues.
DR GO; GO:0005929; C:cilium; IEA:UniProtKB-KW.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.
DR GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0030030; P:cell projection organization; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR039677; RSG1.
DR InterPro; IPR001806; Small_GTPase.
DR PANTHER; PTHR14983:SF1; CILIOGENESIS AND PLANAR POLARITY EFFECTOR 2; 1.
DR PANTHER; PTHR14983; UNCHARACTERIZED; 1.
DR Pfam; PF00071; Ras; 1.
DR PRINTS; PR00449; RASTRNSFRMNG.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Cilium biogenesis/degradation {ECO:0000256|ARBA:ARBA00022794};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW Transport {ECO:0000256|ARBA:ARBA00022927}.
FT REGION 279..299
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 299 AA; 32348 MW; 00235723D28F69BE CRC64;
MARPPAPGSA IVPDWHESPE GKEFLACVLR RSRRRLFGLL ERPVLPPSVA IDTASYKVFV
SGKSGVGKTA LVAKLAGLEV PTAHHETIGC TAPGAPGVGP VQAGTLLRHG QDSQAGILPG
IQTTVVFWPA KLQASDRVVM FRFEFWDCGE AALRKFDHML PACKENTDAF LFLFSFTDRA
SFEDLPGQLA RVAGETPAVV RMVIGSKFDQ YMHTDVPERD LTAFRQAWEL PLLRVKSVPG
RRLADGRTLD GWAGLADVAH VLNGLAEQLW HQDQVAAGLL PNPQRAPPAE EGGITSGHP
//
