ID G1T6E6_RABIT Unreviewed; 799 AA.
AC G1T6E6;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 61.
DE RecName: Full=Nucleolar complex protein 3 homolog {ECO:0000256|PIRNR:PIRNR028977};
DE Short=NOC3 protein homolog {ECO:0000256|PIRNR:PIRNR028977};
GN Name=NOC3L {ECO:0000313|Ensembl:ENSOCUP00000011981.4};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000011981.4, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000011981.4, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000011981.4,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000011981.4}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000011981.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000256|ARBA:ARBA00004604, ECO:0000256|PIRNR:PIRNR028977}.
CC -!- SIMILARITY: Belongs to the CBF/MAK21 family.
CC {ECO:0000256|ARBA:ARBA00007797, ECO:0000256|PIRNR:PIRNR028977}.
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DR EMBL; AAGW02036266; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02036267; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_002718434.1; XM_002718388.3.
DR AlphaFoldDB; G1T6E6; -.
DR SMR; G1T6E6; -.
DR STRING; 9986.ENSOCUP00000011981; -.
DR PaxDb; 9986-ENSOCUP00000011981; -.
DR Ensembl; ENSOCUT00000013937.4; ENSOCUP00000011981.4; ENSOCUG00000013930.4.
DR GeneID; 100348425; -.
DR KEGG; ocu:100348425; -.
DR CTD; 64318; -.
DR eggNOG; KOG2153; Eukaryota.
DR GeneTree; ENSGT00390000008540; -.
DR HOGENOM; CLU_012441_2_1_1; -.
DR InParanoid; G1T6E6; -.
DR OrthoDB; 24935at2759; -.
DR TreeFam; TF318817; -.
DR Proteomes; UP000001811; Chromosome 18.
DR Bgee; ENSOCUG00000013930; Expressed in autopod skin and 15 other cell types or tissues.
DR GO; GO:0005739; C:mitochondrion; IEA:Ensembl.
DR GO; GO:0016607; C:nuclear speck; IEA:Ensembl.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0045444; P:fat cell differentiation; IEA:Ensembl.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR005612; CCAAT-binding_factor.
DR InterPro; IPR011501; Noc3_N.
DR InterPro; IPR016903; Nucleolar_cplx-assoc_3.
DR PANTHER; PTHR14428; NUCLEOLAR COMPLEX PROTEIN 3; 1.
DR PANTHER; PTHR14428:SF5; NUCLEOLAR COMPLEX PROTEIN 3 HOMOLOG; 1.
DR Pfam; PF03914; CBF; 1.
DR Pfam; PF07540; NOC3p; 1.
DR PIRSF; PIRSF028977; Nucleolar_complex_p3; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811}.
FT DOMAIN 213..307
FT /note="Nucleolar complex-associated protein 3 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF07540"
FT DOMAIN 554..707
FT /note="CCAAT-binding factor"
FT /evidence="ECO:0000259|Pfam:PF03914"
FT REGION 31..91
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 449..485
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 38..78
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 799 AA; 92315 MW; 3800CC1D13DAF8E6 CRC64;
MKARRNKKQV PSFRKLIKTS KVKLENKLKN KQFKQQSTLK KYRKEQRKLR QAVKDAVSKK
PVPLEDPKKK RTAKRIEMEE EEEEEALPLD MMDEDDLQLM KDLGQKASFL TRDLSSSEPI
HAKKRKHEHI IDKYEKIPRT LQTAPEKELI HLLPIKDKSG IIPQTREKPV IDSNKEEEDQ
EEMDIEEEVI ENPVRELTIE EHLVERKKKL QEKKMHIAAL ASAIVSDPES NIKKLKELRS
MLMEQDPDVA VTVRKLVIVS LMELFKDITP SYKIRPLTEA EKSSKIRKET QKLREFEEGL
VSQYKFYLEN LEQIIKDWKQ RKLKKSNVIS LKAYKGLAEV AVKSLCELLV ALPHFNFHNN
IIVLIVPLMN DVSKSVSEMC CEAVKKLFKQ DKLGQASLGV IKVISGFVKG RNYEVRPEML
KTFLCLRIKE VEVKKDTEDI NKPKKFMTFK EKRKTLSRMQ RKWKKAEERL ERELLEAEAS
ESTEKKLRLH TETLNIVFVT YFRILKKAQK SPLLPAVLEG LAKFAHLINV EFFDDLLVVL
HTLIESGELS YQESLHCVQT AFHILSGQGD VLNIDPMKFY THLYKTLFKL HAGATNEGVE
IVLQCLDIML TKRRKQVSQQ RALAFIKRLC TLALHVLPNS SIGILATTRV LMHTFPKTDL
LLDNESQGSG VFLPELDEPE YCNAQNTALW ELHALRRHYH PVVQKFAAHL IAGAPVEGSE
ALRPELSRRS AAELFETYSM ATMTFNPPVE SSHSKKKDKI VQGDSLLNED LNQLVKRHCN
EVATQSPLDF TKYLKTSLR
//
