ID G1T6T0_RABIT Unreviewed; 855 AA.
AC G1T6T0;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=N-acetylated alpha-linked acidic dipeptidase 2 {ECO:0000313|Ensembl:ENSOCUP00000012152.4};
GN Name=NAALAD2 {ECO:0000313|Ensembl:ENSOCUP00000012152.4};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000012152.4, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000012152.4, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000012152.4,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000012152.4}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000012152.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004401};
CC Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004401}.
CC Membrane {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane
CC protein {ECO:0000256|ARBA:ARBA00004606}.
CC -!- SIMILARITY: Belongs to the peptidase M28 family. M28B subfamily.
CC {ECO:0000256|ARBA:ARBA00005634}.
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DR EMBL; AAGW02008645; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02008646; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1T6T0; -.
DR SMR; G1T6T0; -.
DR STRING; 9986.ENSOCUP00000012152; -.
DR MEROPS; M28.012; -.
DR Ensembl; ENSOCUT00000014140.4; ENSOCUP00000012152.4; ENSOCUG00000014137.4.
DR eggNOG; KOG2195; Eukaryota.
DR GeneTree; ENSGT01030000234598; -.
DR HOGENOM; CLU_005688_3_2_1; -.
DR InParanoid; G1T6T0; -.
DR TreeFam; TF312981; -.
DR Proteomes; UP000001811; Chromosome 1.
DR Bgee; ENSOCUG00000014137; Expressed in kidney and 14 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR CDD; cd08022; M28_PSMA_like; 1.
DR CDD; cd02121; PA_GCPII_like; 1.
DR Gene3D; 3.50.30.30; -; 1.
DR Gene3D; 1.20.930.40; Transferrin receptor-like, dimerisation domain; 1.
DR Gene3D; 3.40.630.10; Zn peptidases; 1.
DR InterPro; IPR046450; PA_dom_sf.
DR InterPro; IPR003137; PA_domain.
DR InterPro; IPR007484; Peptidase_M28.
DR InterPro; IPR039373; Peptidase_M28B.
DR InterPro; IPR007365; TFR-like_dimer_dom.
DR InterPro; IPR036757; TFR-like_dimer_dom_sf.
DR PANTHER; PTHR10404; N-ACETYLATED-ALPHA-LINKED ACIDIC DIPEPTIDASE; 1.
DR PANTHER; PTHR10404:SF38; N-ACETYLATED-ALPHA-LINKED ACIDIC DIPEPTIDASE 2; 1.
DR Pfam; PF02225; PA; 1.
DR Pfam; PF04389; Peptidase_M28; 1.
DR Pfam; PF04253; TFR_dimer; 1.
DR SUPFAM; SSF52025; PA domain; 1.
DR SUPFAM; SSF47672; Transferrin receptor-like dimerisation domain; 1.
DR SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW Signal-anchor {ECO:0000256|ARBA:ARBA00022968};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 117..140
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 270..358
FT /note="PA"
FT /evidence="ECO:0000259|Pfam:PF02225"
FT DOMAIN 456..659
FT /note="Peptidase M28"
FT /evidence="ECO:0000259|Pfam:PF04389"
FT DOMAIN 726..815
FT /note="Transferrin receptor-like dimerisation"
FT /evidence="ECO:0000259|Pfam:PF04253"
FT REGION 1..32
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 830..855
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 831..847
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 855 AA; 96389 MW; 14896A5221BD663A CRC64;
MIRTLQQPLP GFTGFTQRKL PANRKNSSSD CSAFSLPPLR APGDRWGQAK LGQRCQLFFT
LCTDQEGGGG FGQGPRLLTA FPARALDWLL CSSQATDSSR RSRLRAEEAM ANSRGRLYLW
MCLAAALASF LAGFMVGWFI KPFKGTTTSV RYHQSIRWKL VSEMKAENIK SFLRSFTKLP
HLAGTEQNLL LAKKIQTQWK KFGLDSAKLV HYDVLLSYPN ETNANYISIV NEHGIEIFKT
TSLEPAPDGY ENVTNIVPPY NAFSAQGTPE GDLVYVNYAR TEDFFKLERE MNINCTGKIV
IARYGKIFRG NKVKNAMLAG AIGIILYSDP ADYFAPEVQP YPKGWNLPGT AAQRGNVLNL
NGAGDPLTPG YPAKEYTFRL NVEEGVGIPQ IPVHPIGYND AEILLRYLGG TAPPDESWKG
TLNVGYRIGP GFVGSDSFRK VRMHVHNINK ITRIYNVIGT ITGSVEPDRY VILGGHRDSW
VFGGIDPTSG TAVLQEIAQS FGKLITKGWR PRRTIIFASW DAEEFGLLGS TEWAEENAKI
LQERSIAYIN SDSSIEGNYT LRVDCTPLLY QLVYKLTKEI SSPDDGFESK SLYESWLEKD
PSPENKDFPR INKLGSGSDF EAYFQRLGIA SGRARYTKNR KTDKYSSYPV YHTIYETFEL
VENFYDPTFK KQLSVAQLRG SLVYELADST IIPFNIQDYA KALKNYATSI YNLSKKHDQQ
LKEYGVSFDS LFSAVKNFSE AASDFHRRLT QADLTNPIAV RIMNDQLMLL ERAFIDPLGL
PGRRFYRHII FAPSSHNKYA GESFPGIYDA MFDIENKADP HLAWTEQDQP YETQEGKRME
SEYRNSDPLK HSTWT
//
