ID G1T758_RABIT Unreviewed; 461 AA.
AC G1T758;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE SubName: Full=Phosphoinositide-3-kinase regulatory subunit 3 {ECO:0000313|Ensembl:ENSOCUP00000012307.2};
GN Name=PIK3R3 {ECO:0000313|Ensembl:ENSOCUP00000012307.2};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000012307.2, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000012307.2, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000012307.2,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000012307.2}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000012307.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the PI3K p85 subunit family.
CC {ECO:0000256|ARBA:ARBA00009442}.
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DR EMBL; AAGW02002903; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02002904; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02002905; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02002906; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02002907; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02002908; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02002909; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02002910; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02002911; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02002912; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_017201822.1; XM_017346333.1.
DR AlphaFoldDB; G1T758; -.
DR SMR; G1T758; -.
DR STRING; 9986.ENSOCUP00000012307; -.
DR PaxDb; 9986-ENSOCUP00000016026; -.
DR Ensembl; ENSOCUT00000014318.4; ENSOCUP00000012307.2; ENSOCUG00000014319.4.
DR GeneTree; ENSGT00940000156259; -.
DR HOGENOM; CLU_041839_0_0_1; -.
DR InParanoid; G1T758; -.
DR OrthoDB; 2880119at2759; -.
DR Proteomes; UP000001811; Chromosome 13.
DR Bgee; ENSOCUG00000014319; Expressed in testis and 17 other cell types or tissues.
DR ExpressionAtlas; G1T758; baseline.
DR GO; GO:0005942; C:phosphatidylinositol 3-kinase complex; IEA:Ensembl.
DR GO; GO:0046935; F:1-phosphatidylinositol-3-kinase regulator activity; IEA:Ensembl.
DR GO; GO:0001784; F:phosphotyrosine residue binding; IEA:Ensembl.
DR GO; GO:0002042; P:cell migration involved in sprouting angiogenesis; IEA:Ensembl.
DR GO; GO:0008286; P:insulin receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0043491; P:phosphatidylinositol 3-kinase/protein kinase B signal transduction; IEA:Ensembl.
DR GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
DR GO; GO:0001934; P:positive regulation of protein phosphorylation; IEA:Ensembl.
DR CDD; cd09930; SH2_cSH2_p85_like; 1.
DR CDD; cd09942; SH2_nSH2_p85_like; 1.
DR Gene3D; 1.10.287.1490; -; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 2.
DR InterPro; IPR032498; PI3K_P85_iSH2.
DR InterPro; IPR035020; PI3kinase_P85_cSH2.
DR InterPro; IPR035022; PI3kinase_P85_nSH2.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10155:SF10; PI3K21B, ISOFORM B; 1.
DR Pfam; PF16454; PI3K_P85_iSH2; 1.
DR Pfam; PF00017; SH2; 2.
DR PRINTS; PR00678; PI3KINASEP85.
DR PRINTS; PR00401; SH2DOMAIN.
DR SMART; SM00252; SH2; 2.
DR SUPFAM; SSF55550; SH2 domain; 2.
DR PROSITE; PS50001; SH2; 2.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191}.
FT DOMAIN 65..160
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 358..452
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT COILED 181..208
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 246..294
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 461 AA; 54434 MW; 6834005B66FA0253 CRC64;
MYNTVWSMDR DDADWREVMM PYSTELIFYI EMDPPALPPK PPKPMTSAVT NGMKDSSVSL
QDAEWYWGDI SREEVNDKLR DMPDGTFLVR DASTKMQGDY TLTLRKGGNN KLIKIYHRDG
KYGFSDPLTF NSVVELINHY HHESLAQYNP KLDVKLMYPV SRYQQDQLVK EDNIDAVGKK
LQEYHSQYQE KSKEYDRLYE EYTRTSQEIQ MKRTAIEAFN ETIKIFEEQC HTQEQHSKEY
IERFRREGNE KEIERIMMNY DKLKSRLGEI HDSKMRLEQD LKKQALDNRE IDKKMNSIKP
DLIQLRKIRD QHLVWLNHKG VRQKRLNAWL GIKNEDADET YFINEEDENL PHYDEKTWFV
EDINRVQAED LLYGKPDGAF LIRESSKKGC YACSVVADGE VKHCVIYSTA RGYGFAEPYN
LYSSLKELVL HYQHTSLVQH NDSLNVRLAY PVHAQMPSLC R
//
