ID G1T8R6_RABIT Unreviewed; 348 AA.
AC G1T8R6;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 2.
DT 27-MAR-2024, entry version 74.
DE SubName: Full=Mortality factor 4 like 1 {ECO:0000313|Ensembl:ENSOCUP00000012987.3};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000012987.3, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000012987.3, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke {ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000012987.3}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000012987.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR AlphaFoldDB; G1T8R6; -.
DR SMR; G1T8R6; -.
DR STRING; 9986.ENSOCUP00000012987; -.
DR PaxDb; 9986-ENSOCUP00000012987; -.
DR Ensembl; ENSOCUT00000015111.4; ENSOCUP00000012987.3; ENSOCUG00000015117.4.
DR eggNOG; KOG3001; Eukaryota.
DR GeneTree; ENSGT00950000182965; -.
DR HOGENOM; CLU_039566_4_0_1; -.
DR InParanoid; G1T8R6; -.
DR OMA; GLQTYFD; -.
DR TreeFam; TF323400; -.
DR Proteomes; UP000001811; Unplaced.
DR Bgee; ENSOCUG00000015117; Expressed in testis and 15 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd18983; CBD_MSL3_like; 1.
DR Gene3D; 2.30.30.140; -; 1.
DR Gene3D; 1.10.274.30; MRG domain; 1.
DR InterPro; IPR016197; Chromo-like_dom_sf.
DR InterPro; IPR008676; MRG.
DR InterPro; IPR038217; MRG_C_sf.
DR InterPro; IPR026541; MRG_dom.
DR InterPro; IPR025995; Tudor-knot.
DR PANTHER; PTHR10880; MORTALITY FACTOR 4-LIKE PROTEIN; 1.
DR PANTHER; PTHR10880:SF29; MORTALITY FACTOR 4-LIKE PROTEIN 1; 1.
DR Pfam; PF05712; MRG; 1.
DR Pfam; PF11717; Tudor-knot; 1.
DR PIRSF; PIRSF038133; HAT_Nua4_EAF3/MRG15; 1.
DR SUPFAM; SSF54160; Chromo domain-like; 1.
DR PROSITE; PS51640; MRG; 1.
PE 4: Predicted;
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 1..37
FT /note="Tudor-knot"
FT /evidence="ECO:0000259|Pfam:PF11717"
FT DOMAIN 161..337
FT /note="MRG"
FT /evidence="ECO:0000259|Pfam:PF05712"
FT REGION 99..167
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 142..156
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 348 AA; 39863 MW; 05C643717DED904B CRC64;
ERVLCFHGPL LYEAKCVKVA IKDKQVKYFI HYSGWNKKSA GRPRRSEKTL KTHEDIVALF
PVPEGAPSVH HPLLTSSWDE WVPESRVLKY VDTNLQKQRE LQKANQEQYA EGKMRGAAPG
KKTSGLQQKN VEVKTKKNKQ KTPGNGDGGS TSETPQPPRK KRARVDPTVE NEETFMNRVE
VKVKIPEELK PWLVDDWDLI TRQKQLFYLP AKKNVDSILE DYANYKKSRG NTDNKEYAVN
EVVAGIKEYF NVMLGTQLLY KFERPQYAEI LADHPDAPMS QVYGAPHLLR LFVRIGAMLA
YTPLDEKSLA LLLNYLHDFL KYLAKNSATL FSASDYEVAP PEYHRKAV
//