ID G1T912_RABIT Unreviewed; 1113 AA.
AC G1T912;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 74.
DE SubName: Full=Solute carrier family 9 member C2 (putative) {ECO:0000313|Ensembl:ENSOCUP00000013099.4};
GN Name=SLC9C2 {ECO:0000313|Ensembl:ENSOCUP00000013099.4};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000013099.4, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000013099.4, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000013099.4,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000013099.4}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000013099.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAGW02056511; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1T912; -.
DR STRING; 9986.ENSOCUP00000013099; -.
DR PaxDb; 9986-ENSOCUP00000013099; -.
DR Ensembl; ENSOCUT00000015245.4; ENSOCUP00000013099.4; ENSOCUG00000015222.4.
DR eggNOG; KOG0100; Eukaryota.
DR GeneTree; ENSGT00940000162785; -.
DR HOGENOM; CLU_003400_0_0_1; -.
DR InParanoid; G1T912; -.
DR TreeFam; TF328865; -.
DR Proteomes; UP000001811; Chromosome 13.
DR Bgee; ENSOCUG00000015222; Expressed in testis and 8 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0015385; F:sodium:proton antiporter activity; IEA:InterPro.
DR CDD; cd00038; CAP_ED; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 1.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR018422; Cation/H_exchanger_CPA1.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR10110; SODIUM/HYDROGEN EXCHANGER; 1.
DR PANTHER; PTHR10110:SF91; SODIUM_HYDROGEN EXCHANGER 11; 1.
DR Pfam; PF00027; cNMP_binding; 1.
DR Pfam; PF00999; Na_H_Exchanger; 1.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 1.
PE 4: Predicted;
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 31..49
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 54..72
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 92..113
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 120..140
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 146..162
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 183..203
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 215..235
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 255..282
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 302..323
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 335..363
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 369..393
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 405..425
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 613..634
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 646..663
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 675..694
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 706..730
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 889..955
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
SQ SEQUENCE 1113 AA; 128282 MW; 3C50E784D72F4049 CRC64;
MNSSFWSQKD VNRPDLLCGR SADYLVKKEH FPMLVCSIIV LGGFLRICLK NSEVIVLTIL
SLSGFVIGQL AYHLVEVHQI VYPLLRTPSF SLFSYFLPII IFMAALEVDF YILKNIIWQV
LLTGLISFST AFIIIGYVVL KFNVDSWDLQ SCLLFSIILG ITDPLHSVNS LRTIGVSKMY
TDIIRGESLV ICGFTAIFFG IFRSSPMHIT LFRELHVVMG LILDIFGSTI CGYWCSRIIQ
FILTDLFSNT LTNVILCFSM VYMTFFVVEF FGMSGIVALI TVGLNLDSLS FKPKMEFVIT
KFLVMLSSVY QHLIYTFFGI VIGCGETKHF GFHTVAFMSI LFATVNFVRL LTVFLVSPIL
VYWSYEYNWR WGVVITWSGI KGVFSILLAP DVYNLAEKKV EAPHMFVFYV QVISLLTMGI
NSYMMSQCAR TLGLCAISLP RQMAMQNAFQ HIQDIIQNTI TLFKTEKILT SVNWVLVEEK
TRMEYVTPFS RVSKDGKERE ESPTDEVLIE EARLHVAIIQ MSSFEKQCND GILGTEAARI
LIGATKSYCP IQGKFMSIYD VSTYVRARSW LMKFKNMLTY LEYHKERTPY FLPGSNKFLI
FVYHIVFSEE FEYAGHIVTL MYMYPLIIHL WPMARELNVS ALMSLNYYYM FLYILESSLK
IIIMKKKYFK QHWNILEFLI IVVGIADIIC IYFVRLRPDN LLLIQFTVMI GFLRIIRFLP
IFKVIIPVLI KIAEVQVKKR LSLMYNITKG YVKSQEDAKL LVKQISGRES IYQKLYEILE
TNKRDAVKEL GLIEHEGRDV VIALKTKQAI RNVIAKALKN LTFLWSRGII DKHEGIEMNK
VLLTKIKALN NFPMAIPPPT PDKYLPNIIW LENKDVLIEF FKERTKLAYF DYGDVICREG
EMPQGIYLII SGMASLHSSS PTFGIDSSLR PDRESKTLFT EYCTSGDVLG ELSCLLKREI
EYTAICETIL QAFFISLEDL YEGFDVFWPS LEYKIWLKLA LDTACQYFES SLVDEDLKFQ
KCVLHNHAYV ETLSSYNELA INNVTMKFVI IVYGSVINTK TEEPYFAPYI IPKTCEQVRK
ILCGRCLFPY KPQLVLLKRN LTWKKSAVLS CPY
//
