ID G1T924_RABIT Unreviewed; 980 AA.
AC G1T924;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 72.
DE SubName: Full=Seizure related 6 homolog {ECO:0000313|Ensembl:ENSOCUP00000013113.4};
GN Name=SEZ6 {ECO:0000313|Ensembl:ENSOCUP00000013113.4};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000013113.4, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000013113.4, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000013113.4,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000013113.4}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000013113.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00302}.
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DR EMBL; AAGW02049839; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_008269224.1; XM_008271002.2.
DR AlphaFoldDB; G1T924; -.
DR Ensembl; ENSOCUT00000015261.4; ENSOCUP00000013113.4; ENSOCUG00000015254.4.
DR GeneID; 100348018; -.
DR CTD; 124925; -.
DR eggNOG; KOG4297; Eukaryota.
DR GeneTree; ENSGT00940000156995; -.
DR HOGENOM; CLU_011474_2_0_1; -.
DR OrthoDB; 5350762at2759; -.
DR Proteomes; UP000001811; Chromosome 19.
DR Bgee; ENSOCUG00000015254; Expressed in frontal cortex and 3 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd00033; CCP; 5.
DR CDD; cd00041; CUB; 3.
DR Gene3D; 2.10.70.10; Complement Module, domain 1; 5.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 3.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR InterPro; IPR035976; Sushi/SCR/CCP_sf.
DR InterPro; IPR000436; Sushi_SCR_CCP_dom.
DR PANTHER; PTHR45656; PROTEIN CBR-CLEC-78; 1.
DR PANTHER; PTHR45656:SF1; SEIZURE PROTEIN 6 HOMOLOG; 1.
DR Pfam; PF00431; CUB; 2.
DR Pfam; PF00084; Sushi; 5.
DR SMART; SM00032; CCP; 5.
DR SMART; SM00042; CUB; 2.
DR SUPFAM; SSF57535; Complement control module/SCR domain; 5.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 3.
DR PROSITE; PS01180; CUB; 3.
DR PROSITE; PS50923; SUSHI; 5.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00302}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW Signal {ECO:0000256|SAM:SignalP};
KW Sushi {ECO:0000256|PROSITE-ProRule:PRU00302};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..980
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5023816959"
FT TRANSMEM 910..935
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 244..353
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 355..414
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 416..527
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 530..591
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 593..704
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 708..767
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 769..832
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 836..897
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT REGION 90..203
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 233..263
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 92..106
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 107..142
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 233..252
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 244..271
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00059"
FT DISULFID 416..443
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00059"
FT DISULFID 738..765
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
SQ SEQUENCE 980 AA; 105847 MW; 406D6A08776BA9E6 CRC64;
MRFVALLLLP LLLALLAHGL SSEAPTVGEG QAADMEDMDG ELTVAPTPEQ PDHGVRFVTT
APTLKLLNHH PLLEEFLQEG LEAGEEELRP ALPFQPDPPT PFTPSPLPRL ANQDNRPVFT
SPTPAMAAAP TQPQSSEGRW SLQSEPPGLH LTAPLPPGPS MAAPTLGPGA RPSTTPPSRV
WTPTQEGPGD MGRPWAPEPM SHTTGLAVKG TIATATASGD DEESTTTTTI VTTTITTVQP
PGSCNWNFSG PEGSLDSPGG PSSPPDVSLD CFYYISVYPG YGVEIKVQNI SLREGETMTV
EGLGGPDPLP LANQSFLLRG QVIRSPTHQA ALRFQSLPPP AGPGTFHFHY QAYLLSCRFP
QRPAYGHVTV TSLHPGGSAR FHCATGYQLK GARLLTCLNA TQPFWDSREP VCIAACGGVI
RNATTGRIVS PGFPGNYSNN LTCHWLLEAP EGQRLHLHFE KVSLAEDDDR LIIRNGDNVE
APPVYDSYEV EYLPIEGLLS SGRHFFVELS TDSSGAAAGM ALRYEAFQQG HCYEPFVKYG
NFSSSAPSYP VGTTVEFSCD PGYTLEQGSI IIECVDPHDP QWNETEPACR AVCSGEITDS
AGVVLSPNWP EPYGRGQDCI WGVHVEEDKR IMLDVRVLRI GPADVLTFYD GDDLTARVLG
QYSGPRGHVK LFTSMADVTI QFQSDPGTSV LGYQQGFVIH FFEVPRNDTC PELPEIPNGW
KSPSQPELVH GTVVTYQCYP GYQVVGSSVL MCQWDLSWSE DLPSCQKVTS CRDPGDVEHS
RRLISSPKFP VGATVQYICD QGFVLTGSAI LTCHDRQAGS PKWSDRAPKC LLEQLKPCHG
LSAPKNGARS PEKRLHPAGA TVHFSCAPGY VLKGQASIKC VPGHPSHWSD SPPICRAVAK
SPAAPSTLDA AHIAAVIFLP LVAMVLLAGG VYLYFSRLQG KSPLQLPGTR PRPYNRITVE
SAFDNPTYEA GETREYEVSI
//
