ID G1T9B9_RABIT Unreviewed; 1331 AA.
AC G1T9B9;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 77.
DE SubName: Full=Neurofascin {ECO:0000313|Ensembl:ENSOCUP00000013222.4};
GN Name=NFASC {ECO:0000313|Ensembl:ENSOCUP00000013222.4};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000013222.4, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000013222.4, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000013222.4,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000013222.4}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000013222.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the immunoglobulin superfamily.
CC L1/neurofascin/NgCAM family. {ECO:0000256|ARBA:ARBA00008588}.
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DR EMBL; AAGW02025351; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02025352; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02025353; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02025354; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02025355; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02025356; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR SMR; G1T9B9; -.
DR STRING; 9986.ENSOCUP00000013222; -.
DR PaxDb; 9986-ENSOCUP00000013222; -.
DR Ensembl; ENSOCUT00000015388.4; ENSOCUP00000013222.4; ENSOCUG00000015363.4.
DR eggNOG; KOG3513; Eukaryota.
DR GeneTree; ENSGT00940000157024; -.
DR HOGENOM; CLU_005756_1_1_1; -.
DR InParanoid; G1T9B9; -.
DR Proteomes; UP000001811; Chromosome 16.
DR Bgee; ENSOCUG00000015363; Expressed in brain and 13 other cell types or tissues.
DR GO; GO:0030424; C:axon; IEA:UniProt.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR CDD; cd00063; FN3; 5.
DR CDD; cd05731; Ig3_L1-CAM_like; 1.
DR CDD; cd05845; IgI_2_L1-CAM_like; 1.
DR CDD; cd05875; IgI_hNeurofascin_like; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 11.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013151; Immunoglobulin.
DR InterPro; IPR026966; Neurofascin/L1/NrCAM_C.
DR InterPro; IPR026965; NFASC_Ig-like.
DR PANTHER; PTHR44170:SF12; NEUROFASCIN; 1.
DR PANTHER; PTHR44170; PROTEIN SIDEKICK; 1.
DR Pfam; PF13882; Bravo_FIGEY; 1.
DR Pfam; PF00041; fn3; 4.
DR Pfam; PF07679; I-set; 3.
DR Pfam; PF00047; ig; 1.
DR Pfam; PF13927; Ig_3; 2.
DR SMART; SM00060; FN3; 5.
DR SMART; SM00409; IG; 6.
DR SMART; SM00408; IGc2; 6.
DR SUPFAM; SSF49265; Fibronectin type III; 3.
DR SUPFAM; SSF48726; Immunoglobulin; 6.
DR PROSITE; PS50853; FN3; 5.
DR PROSITE; PS50835; IG_LIKE; 6.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1201..1222
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 98..194
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 200..287
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 318..406
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 411..498
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 503..591
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 595..677
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 689..784
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 789..882
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 887..989
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 993..1089
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1096..1190
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 1..57
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 772..798
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 974..993
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1071..1100
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1232..1331
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1232..1256
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1258..1279
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1302..1316
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1317..1331
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1331 AA; 149384 MW; 2242924DCA1B1E24 CRC64;
MGLAHLSLQG EPEKTADEPG RDSLTRELSS VQEAQLERLK AARPRGPGSR ERGLVPRMAR
PQPPPWVHAA FLLCVLGLGG AIEIPMDPSI QNELTQPPTI TKQSVKDHIV DPRDNILIEC
EAKGNPAPSF HWTRNSRFFN IAKDPRVSMR RRSGTLVIDF RSGGRPEEYE GEYQCFARNK
FGTALSNRIR LQVSKSPLWP KENLDPVVVQ EGAPLTLQCN PPPGLPSPVI FWMSSSMEPI
TQDKRVSQGH NGDLYFSNVI LQDMQTDYSC NARFHFTHTI QQKNPFTLKV LTNHPYNDSS
LRNHPDMYSA RGVAERTPSF MYPQGTSSSQ MVLRGMDLLL ECIASGVPTP DIAWYKKGGD
LPSDKAKFEN FNKALRITNV SEEDSGEYFC LASNKMGSIR HTISVRVKAA PYWLDEPKNL
VLAPGEDGRL VCRANGNPKP TVQWMVNGEP LQSAPPNPNR EVAGDTIIFR DTQISSRAVY
QCNTSNEHGY LLANAFVSVL DVPPRMLSPR NQLIRVILYN RTRLDCPFFG SPIPTLRWFK
NGQGSNLDGG NYHVHENGSL EIKMIRKEDQ GIYTCVATNI LGKAENQVRL EVKDPTRIYR
MPEDQVAKRG TTVQLECRVK HDPSLKLTVS WLKDEEPLYI SNRMKKEDDS LTIFGVAEKD
QGSYTCVAST ELDQDLAKAY LTVPGRPDRP RDLELTDLAE RSVRLTWIPG DANNSPITDY
VVQFEEDQFQ PGVWHDHSKF PGNVNSAVLQ LSPYVNYQFR VIAINEVGSS HPSLPSERYR
TSGAPPESNP GDVKGEGTRK NNMEITWTPM NATSAFGPNL RYIVKWRRRE TRDAWNNATV
WGSRYVVGQT PVYVPYEIRV QAENDFGKAP EPETVIGYSG EDYPRAAPTD VKVRVMNSTA
ISLQWNRVYS DTVQGQLREY RAYYWRESSL LKNLWVSQKR QQASFPGDRP RGVVSQLFPY
SNYKLEMVVV NGRGDGPRSE TKEFTTPEGV PSAPRRFRVR QPNLETINLE WDHPEHPNGI
LVGYTLKYLP FNGTKLGKQI VENFSPNQTK FTVQRADPVS RYRFTLSART QVGSGEAVTE
ESPAPPNEAT PTAAHPPAPD EQSIWNVTVL PNSKWANITW KHNFGPGTDF VVEYIDSNHT
KKTVPVKAQA QPIQLTDLYP GMTYTLRVYS RDHEGISSTV ITFMTSTAYT NNQADIATQG
WFIGLMCAIA LLVLILLIVC FIKRSRGGKY PVREKKDVPL GPEDPKEEDG SFDYSDEDNK
PLQGSQTSLD GTIKQQESDD SLVDYGEGGE GQFNEDGSFI GQYTVKKDKE ETEGNESSEA
TSPVNAIYSL A
//
